Action of the 4-Nitro-2-phenoximethanesulphonanilide (Nimesulide) on neutrophil chemotaxis and superoxide production

Mello, Suzana Beatriz Verissímo de; Laurindo, Iêda Maria Magalhães; Cossermelli, W

doi:10.1590/s1516-31801994000100003

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…The role of neutrophil involvement in CIA and joint damage is well established. Yet, the anti-chemotaxis effect of nimesulide might partly explain the synergistic interaction with leflunomide in terms of disease progression [25], [34].…”

Section: Discussionmentioning

confidence: 99%

Nimesulide Improves the Symptomatic and Disease Modifying Effects of Leflunomide in Collagen Induced Arthritis

et al. 2014

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Nimesulide is a COX-2 inhibitor used for symptomatic relief of rheumatoid arthritis. Leflunomide is an anti-pyrimidine used to manage the progression of rheumatoid arthritis. Herein we studied the influence of nimesulide and leflunomide combination in terms of disease symptoms and progression using collagen-induced arthritis model in mice, as a model for rheumatoid arthritis. Collagen induced arthritis was induced by immunization with type II collagen. Assessment of joint stiffness and articular hyperalgesia were evaluated using a locomotor activity cage and the Hargreaves method, respectively. Disease progression was assessed via arthritic index scoring, X-ray imaging, myeloperoxidase enzyme activity and histopathologic examination. Nimesulide induced only transient symptomatic alleviation on the top of decreased leucocytic infiltration compared to arthritis group. However, nimesulide alone failed to induce any significant improvement in the radiological or pathological disease progression. Leflunomide alone moderately alleviates the symptoms of arthritis and moderately retarded the radiological and pathological disease progression. Combination of nimesulide and leflunomide significantly improved symptomatic (analgesia and joint stiffness) and arthritic disease progression (radiological, pathological and Myeloperoxidase enzyme activity) in collagen induced arthritis animal model.

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Section: Discussionmentioning

confidence: 99%

Nimesulide Improves the Symptomatic and Disease Modifying Effects of Leflunomide in Collagen Induced Arthritis

et al. 2014

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“…Functional modulation of neutrophils is another potential treatment avenue. Anti‐inflammatory agents that block or inhibit one or more neutrophil functions such as chemotaxis, adherence, infiltration, or degranulation may be worth exploring 72‐79 . Glucocorticoid steroids exert powerful, negative effects on inflammation and at first glance would appear to be excellent candidates for use in the modulation of neutrophil function.…”

Section: Treatment Of Chronic Woundsmentioning

confidence: 99%

“…Anti-inflammatory agents that block or inhibit one or more neutrophil functions such as chemotaxis, adherence, infiltration, or degranulation may be worth exploring. [72][73][74][75][76][77][78][79] Glucocorticoid steroids exert powerful, negative effects on inflammation and at first glance would appear to be excellent candidates for use in the modulation of neutrophil function. However, corticosteroids are pleiotropic in their functions, using several pathways on many targets to elicit their effects.…”

Section: Treatment Of Chronic Woundsmentioning

confidence: 99%

The proteolytic environment of chronic wounds

Yager

Nwomeh

1999

Wound Repair Regeneration

337

218

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A consistent feature of chronic leg and pressure ulcers is chronic inflammation associated with an elevated infiltration of neutrophils. Neutrophils and their proteases have been implicated in mediating the tissue damage associated with a variety of chronic inflammatory diseases. This review discusses our current understanding of the proteolytic enzymes found in chronic wounds and attempts to relate this information to the abundant presence of neutrophils. In addition, the implications that the proteolytic environment may have for current and future treatment strategies of chronic nonhealing wounds are discussed.

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“…The free-radical and hydroxyl scavenging activity of nimesulide have also been reported by Facino et al (1995) who observed a speci®c hydroxyl-radical-scavenging activity of nimesulide, which was able to prevent and limit the freeradical-mediated tissue damage in both acute and chronic in¯ammatory situations. De Mello et al (1994) demonstrated that nimesulide-exposed peripheral neutrophils from healthy subjects produced signi®cantly less superoxide when challenged by PMA (50 ng mL À1 ) and opsonized zymosan (1 mg mL À1 ). Nimesulide effectively decreased the PMN chemotaxis when challenged by leukotriene and fMLP.…”

mentioning

confidence: 99%

Review Nimesulide: Some Pharmaceutical and Pharmacological Aspects—An Update

Singla

Chawla

Singh

2000

Journal of Pharmacy and Pharmacology

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Nimesulide, a non-steroidal anti-inflammatory drug (NSAID), is administered orally or rectally twice daily for a variety of inflammation and pain states. This is a unique NSAID, not only because of its chemical structure but also because of its specific affinity to inhibit cyclooxygenase-2 (COX-2), thus exerting milder effects on the gastrointestinal mucosa. Current data on selective COX-2 inhibitors suggest that they may have an efficacy similar to that of standard NSAIDs. Initial general clinical experience with selective COX-2 inhibitors appears to show that they are particularly promising in individuals at risk because of renal diseases, hypertension or congestive heart failure. Various experimental models and clinical studies have demonstrated the anti-inflammatory efficacy of nimesulide. Nimesulide is superior, or at least comparable in efficacy, to other NSAIDs, but is better tolerated and has less potential for adverse reactions. Thus, selective COX-2 inhibitors should have anti-inflammatory effects devoid of side effects on the kidney and stomach. They may also demonstrate new important therapeutic benefits as anticancer agents as well as help prevention of premature labour and even retard the progression of Alzheimer's disease. No clinically significant drug interactions have been reported for nimesulide. Not much has been reported about the pharmaceutical aspects of nimesulide. Its poor aqueous solubility poses bioavailability problems in-vivo. This could be overcome by the formation of inclusion complexes with beta-cyclodextrin, as has been reported by various researchers. However, absence of any in-vivo data regarding the relative absorption of nimesulide from beta-cyclodextrin complex compared with that from conventional formulations of the drug makes the use of such fast-releasing complexes rather questionable. Only a limited number of assay procedures (HPLC, spectrophotometric, spectrofluorimetric) for the determination of nimesulide and its metabolite in plasma/urine samples or in dosage forms have been reported in the literature. The purpose of this review is to provide a concise overview of the pharmacological and pharmaceutical profile of nimesulide. Various investigations carried out recently are reported, although older references to research performed on nimesulide have also been included, where appropriate.

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Action of the 4-Nitro-2-phenoximethanesulphonanilide (Nimesulide) on neutrophil chemotaxis and superoxide production

Cited by 5 publications

References 27 publications

Nimesulide Improves the Symptomatic and Disease Modifying Effects of Leflunomide in Collagen Induced Arthritis

Nimesulide Improves the Symptomatic and Disease Modifying Effects of Leflunomide in Collagen Induced Arthritis

The proteolytic environment of chronic wounds

Review Nimesulide: Some Pharmaceutical and Pharmacological Aspects—An Update

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