Si-tricalcium phosphate cement: preparation, characterization and bioactivity in SBF

Motisuke, Mariana; Carrodeguas, Raúl García; Zavaglia, Cecília Amélia de Carvalho

doi:10.1590/s1516-14392011005000065

Cited by 10 publications

(7 citation statements)

References 20 publications

(39 reference statements)

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“…The lower content of β-TCP on Si-α-TCP confirms the efficiency of Silicon in stabilizing the α-TCP phase by lowering the β → α phase transformation temperature 4,5,22 once the powder doped with Silicon resulted on purer α-TCP (4 wt. (%) of β-TCP) at a lower sintering temperature work were sintered for longer times it would be expected a reduction on β-TCP content.…”

Section: Discussionmentioning

confidence: 67%

“…(1250 °C). Based on results reported on the literature [22][23][24] depending on the Magnesium content in the precursors employed the temperature at which pure α-TCP can be synthesized could be raised up to 1500 °C, however, if the material is sintered at the right temperature and for enough time to guarantee the total β → α conversion it is possible to obtain pure α-TCP no matter how high is the Mg contamination. Then, if the powders synthesized on this…”

Section: Discussionmentioning

confidence: 99%

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Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Motisuke

Carrodeguas²,

Zavaglia

2012

Mat. Res.

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The influence of silicon doping on calcium phosphate cement were explored in this work. α-TCP and Si-α-TCP were prepared by solid state reaction employing "Mg-free" CaHPO 4 , CaCO 3 and CaSiO 3 as precursors. It was possible to obtain TCP powders with low contents of β phase as contaminant. Cement liquid phase was an aqueous solution containing 2.5 wt. (%) of Na 2 HPO 4 and 1.5 wt. (%) of citric acid. The liquid-to-powder ratio was 0.6 mL.g -1. Chemical, physical and mechanical properties of the cement samples were determined by means of XRD, FTIR, XRF, compressive strength and SEM. The calcium phosphate cements obtained achieved satisfactory properties; however, Si-α-TCP presented a decrease on the rate of setting reaction.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Motisuke

Carrodeguas²,

Zavaglia

2012

Mat. Res.

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“…Imaging of Surface Morphology and Apatite Formation: For imaging of surface morphology and apatite formation, cement samples were kept in either PBS or SBF at 37 °C for 24 h. [96] After 24 h, the aqueous media were removed and specimens were lyophilized. Lyophilized samples were sputter coated with platinum, and cross-sectional images of fractured surfaces were taken with a Philips-FEI XL30 SEM in secondary electron mode in 100x-100,000x magnification.…”

Section: Methodsmentioning

confidence: 99%

Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics

et al. 2023

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Herein, fullerenol (Ful), a highly water‐soluble derivative of C60 fullerene with demonstrated antioxidant activity, is incorporated into calcium phosphate cements (CPCs) to enhance their osteogenic ability. CPCs with added carboxymethyl cellulose/gelatin (CMC/Gel) are doped with biocompatible Ful particles at concentrations of 0.02, 0.04, and 0.1 wt v%−1 and evaluated for Ful‐mediated mechanical performance, antioxidant activity, and in vitro cellular osteogenesis. CMC/gel cements with the highest Ful concentration decrease setting times due to increased hydrogen bonding from Ful's hydroxyl groups. In vitro studies of reactive oxygen species (ROS) scavenging with CMC/gel cements demonstrate potent antioxidant activity with Ful incorporation and cement scavenging capacity is highest for 0.02 and 0.04 wt v%−1 Ful. In vitro cytotoxicity studies reveal that 0.02 and 0.04 wt v%−1 Ful cements also protect cellular viability. Finally, increase of alkaline phosphatase (ALP) activity and expression of runt‐related transcription factor 2 (Runx2) in MC3T3‐E1 preosteoblast cells treated with low‐dose Ful cements demonstrate Ful‐mediated osteogenic differentiation. These results strongly indicate that the osteogenic abilities of Ful‐loaded cements are correlated with their antioxidant activity levels. Overall, this study demonstrates exciting potential of Fullerenol as an antioxidant and proosteogenic additive for improving the performance of calcium phosphate cements in bone reconstruction procedures.

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“…SiO 2 added HA performs superior bioactivity than that of pure HA in SBF [92]. Also, reaction product silicon increases the bioactivity of α-TCP [93].…”

Section: In-vitro Bioactivity Characterizationmentioning

confidence: 96%

Phase analysis, mechanical properties and in vitro bioactivity of graphene nanoplatelet-reinforced silicon nitride-calcium phosphate composites

Bozkurt

Akarsu

Akin

et al. 2021

Journal of Asian Ceramic Societies

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The aim of this study is to produce highly dense Si 3 N 4 based composites with good mechanical properties and bioactivity. Si 3 N 4 ceramics without using sintering aids, Si 3 N 4-HA and Si 3 N 4-HA-GNP based composites have been produced by spark plasma sintering (SPS) at temperatures of 1525-1550°C. The effect of reinforcement type and content on the densification behavior, phase analysis, microstructural development, mechanical properties, and in-vitro bioactivity behavior of Si 3 N 4 were systematically investigated. Monolithic Si 3 N 4 that contains a high amount of β-Si 3 N 4 phase (~87 wt%) was produced by nearly full densification (~99%). Hydroxyapatite (HA) was used as a starting powder during the preparation of binary and triple composites to provide bioactivity to Si 3 N 4 , and after sintering, HA transformed into tricalcium phosphate (β-TCP and α-TCP) polymorphs. The incorporation of GNPs had a positive effect on the stability of β-TCP phases at higher sintering temperatures. The improvement in indentation fracture toughness of the samples with GNP reinforcement was mainly attributable to pull-out and crack deflection mechanisms. In-vitro bioactivity of GNP added composites enhanced with increasing α-TCP content. More calcium phosphate-based particle formation was observed in Si 3 N 4-HA-GNP composites compared to the Si 3 N 4-HA.

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Si-tricalcium phosphate cement: preparation, characterization and bioactivity in SBF

Cited by 10 publications

References 20 publications

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Si-TCP synthesized from "Mg-free" reagents employed as calcium phosphate cement

Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics

Phase analysis, mechanical properties and in vitro bioactivity of graphene nanoplatelet-reinforced silicon nitride-calcium phosphate composites

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