Analysis of bioactive glasses obtained by sol-gel processing for radioactive implants

Abstract

This paper presents the chemical and physical characterizations of SiO 2 and SiO 2 -CaO bioactive glasses incorporated with samarium atoms, produced by sol-gel synthesis. The objective is to provide biocompatible and biodegradable radioactive seeds as an alternative to be used in Brachytherapy for the treatment of prostate cancer. The glasses were produced and analyzed by X-ray fluorescence spectroscopy (XRF), energy dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), He picnometry and nitrogen adsorption analysis. A theoretical evaluation of the specific activity of the samples upon neutron activation is proposed. The XRF and EDS results demonstrate the incorporation of samarium atoms in the glass matrix. The experimental data coupled with the theoretical studies in neutron activation suggest that it is possible to obtain radioactive seeds with activities equivalent to 125 I seeds used in brachytherapy prostatic.

Sistema computacional para dosimetria de nêutrons e fótons baseado em métodos estocásticos aplicado a radioterapia e radiologia

“…A voxel model of a rabbit head was built by Costa in order to study bioglass implants in the brain (17) . The implants comprise 15 Ca-Si bioglass seeds with Sm-153 (18)(19)(20)(21) . A voxel model was built at SISCODES based on CT images of the animal.…”

Bioactivity and cell proliferation in radiopaque gel-derived CaO–P2O5–SiO2–ZrO2 glass and glass–ceramic powders

“…For instance, bioactive glasses containing Mg, Zn, Ag, Sr, Na, K, B, F, Ce, Ga and Sm have been tested, and certain of these materials have special properties for use in specific applications [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. In this work, we focus on the effect of zirconium (Zr) incorporated in the bioactive gel-derived glass powder.…”

Evaluation of a Proposed Biodegradable 188Re Source for Brachytherapy Application

“… 24 The sol-gel process is a chemical technique that can be utilized for producing glasses, ceramics, ceramic glasses, and other composites. 18 , 25 , 26 Here, this technique has been applied to manufacture a new bioactive glass seed. Previous works showed that the high degradability of bioactive glasses can be produced by the sol-gel technique.…”