Atividade anti-helmíntica de plantas nativas do continente americano: uma revisão

Falcão, Helena; Barbosa-Filho, José Maria; Diniz, Margareth F. F. Melo; Batista, Leônia Maria

doi:10.1590/s1516-05722013000200018

Cited by 8 publications

(10 citation statements)

References 18 publications

(7 reference statements)

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“…Outro aspecto importante no uso de plantas é que além de possuírem compostos bioativos com propriedades medicinais, apresentam baixo custo (Sousa et al 2013).…”

Section: Introductionunclassified

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

et al. 2014

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1051 tigada a concentração de extrato com efeito bioativo, pelo teste de evolução da toxicidade do extrato etanólico de J. mollissima sobre o microcrustáceo Artemia salina, obtendo uma CL50 de 660,80µg/ml, que foi testada em coproculturas contendo larvas infectantes de Haemonchus contortus e em animais para a verificação da redução do OPG. Para o teste in vivo o extrato foi dissolvido em água para se obter as concentrações 660,80µg/ml e 1321,6µg/ml, foram coletadas fezes semanalmente e sangue quinzenalmente. This study aimed to evaluate the anthelmintic effect of Jatropha mollissima through in vitro and in vivo experiments. Initially we investigated the concentration of extract with bioactive effect, through the toxicity evolution test of the ethanol extract of J. mollissima on the microcrustacean Artemia salina, obtaining CL50 concentration of 660.80µg/ml, which was tested in fecal cultures containing infective larvae of Haemonchus contortus and in animals for the verification of OPG reduction. For in vivo test, the extract was dissolved in water to obtain concentrations of 660.80µg/ml and 1321.6µg/ml. Feces were collected weekly and blood was collected every fifteen days. As a result of in vitro test, the ethanol extract of the stem of J. mollissima proved toxic on A. salina, with CL50 less than 1000µg/ ml and inhibited the eggs hatching and the development of larvae of H. contortus, presenting an efficiency of 70.77%. In vivo test revealed that the extract is also effective in sheep, with a significant reduction in the count of OPG after 28 days of experiment, 47 and 44% of reduction in the groups treated with the extract, 7.5% in the untreated group of animals and 40.6% with ivermectin. Even parasitized, the animals remained clinically healthy and without anemia. The ethanol extract of the stem of Jatropha mollissima may represent an alternative to the control of sheep worms, because it slows the parasitic resistance.

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“…Outro aspecto importante no uso de plantas é que além de possuírem compostos bioativos com propriedades medicinais, apresentam baixo custo (Sousa et al 2013).…”

Section: Introductionunclassified

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

et al. 2014

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“…Of all the plants that have been studied, the anthelmintic activity was confirmed by in vitro or in vivo studies and, depending on the plant species or investigated parasite, this activity was or was not confirmed (Sousa et al, 2013;Camurça-Vasconcelos et al, 2005). It is therefore necessary when evaluating the anthelmintic activity of plant extracts to consider at least important factors, including: type of extract, plant part used, concentration / dose, route of administration, bioassay used, infected animal species and parasite species.…”

Section: Resultsmentioning

confidence: 99%

“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License and larvicidal activity against various parasites (Lone et al, 2012;Bi and Goyal, 2012;Sousa et al, 2013).…”

Section: Introductionmentioning

confidence: 89%

Larvicidal potential of Mikania glomerata SPRENGEL extract on Ancylostoma caninum larvae

AraÃojo¹,

Lacerda²,

Hiura³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Parasitic diseases are seen as indicators of a country's socioeconomic development, constituting a major public health problem as they cause direct health problems related to the lack of piped water, no sewage system, and lack of orientation. Contamination by the geohelminth Ancylostoma spp, causes the Cutaneous larva migrans (CLM), also known as "sandworms", presenting skin lesions of linear and serpiginous character. The aim of this study was to evaluate the in vitro larvicidal potential of guaco extracts (Mikania glomerata SPRENGEL) at different concentrations on A. caninum larvae. Obtained results showed the larvicidal effect of the M. glomerata extract starting from a treatment of 10mg/ml of guaco extracts (p<0.01). The larvicidal activity was best demonstrated in the 25 mg/ml treatment, in which a decrease of 13.30% of L3 was observed compared to the control group, and in the 50 mg/ml treatment (61.66%) reduction of L3. By means of the results, the applicability of the plant extracts used is suggested in A. caninum larvae control. In addition, more research is suggested to assess their employability in different extract forms, new concentrations, and in vivo studies, in order to ensure further clarification on the agents responsible for the observed effects, degree of efficacy and toxicity, and research continuity regarding the use concentration of the plant M. glomerata SPRENGEL.

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“…In this regard, various studies employing medicinal plants and their derivatives have shown ovicidal and larvicidal activities against several parasites (8)(9)(10)(11)(12)). An in vitro study, conducted by Macedo et al (8) with the essential oil of Eucalyptus globulus L. on hatching and development of Haemonchus contortus larvae, a gastrointestinal nematode of ruminants, showed ovicidal and/or larvicidal activity and potential for use in its control.…”

Section: Introductionmentioning

confidence: 99%

“…A study involving Carica papaya L. extract, suggested a potential role for this plant as an anthelmintic against infections caused by A. caninum in mice (10,11). Another, in vitro study showed larvicidal activity of leaf extracts from C. ambrosioides L., against T. canis infective larvae (13).…”

Section: Introductionmentioning

confidence: 99%

Activity of Euterpe edulis Martius, Mikania glomerata Spreng, and Mikania laevigata Schultz Bip. Extracts on Gastrointestinal Nematodes Toxocara canis and Ancylostoma caninum

Zamprogno

Lopes

Lacerda

et al. 2015

Arch Clin Infect Dis

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Background:Gastrointestinal parasitoses have high rates of morbidity and mortality. Each year about 3.5 billion people are affected by these diseases and 65,000 of them die, mostly in developing countries due to lack of basic sanitation, malnutrition, and poor access to medication. Thus, they constitute an important public health problem due to causing direct health problems related to lack of piped water, absence of sewage system, and lack of orientation. Objectives: Two in vitro assays were performed to evaluate the larvicidal and/or ovicidal activity of ethanol extracts obtained from the plants Euterpe edulis, Mikania laevigata, and Mikania glomerata on the gastrointestinal nematodes Toxocara canis and Ancylostoma caninum. Materials and Methods: In the first assay (A), T. canis eggs were exposed to three different concentrations (0.1 mg/mL, 1 mg/mL, and 10 mg/mL) of each extract, three different concentrations of albendazole (positive control), ethanol (solvent), and a negative control (no treatment), for 15 days at 26°C, under the shelter of light in order to evaluate the percentage of embryonated eggs in the presence of these extracts. In the second assay (B), the larvicidal activities of the species studied were evaluated in the different extract concentrations (0.1 mg/mL, 1 mg/mL, and 10 mg/mL), control, and solvent (ethanol), in coprocultures positive for A. caninum eggs. Results: In assay A, the results demonstrated inhibitory embryogenesis activity on T. canis eggs; however, no difference (P > 0.01) was found between the activities of the extracts. In the control group, there was a difference (P < 0.01) in relation to the tested extracts, in which this difference was not concentration-dependent. In assay B, all extracts showed inhibitory (P > 0.01) hatchability activity of A. caninum eggs in the control group. Conclusions: Through these results, the applicability of the used extracts in the control of eggs and/or larvae of T. canis and A. caninum is suggested. However, it is worth mentioning that further studies should be performed with the species E. edulis, M. glomerata and M. laevigata, using different extracts, new concentrations, and in vivo studies, in order to ensure further clarification on the agents responsible for the observed effects, degree of efficacy, and toxicity.

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Atividade anti-helmíntica de plantas nativas do continente americano: uma revisão

Cited by 8 publications

References 18 publications

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

Larvicidal potential of Mikania glomerata SPRENGEL extract on Ancylostoma caninum larvae

Activity of Euterpe edulis Martius, Mikania glomerata Spreng, and Mikania laevigata Schultz Bip. Extracts on Gastrointestinal Nematodes Toxocara canis and Ancylostoma caninum

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