Avaliação toxicológica pré-clínica do chá das folhas de Morus nigra L. (Moraceae)

Abstract

RESUMO:O objetivo desse estudo foi realizar um ensaio toxicológico pré-clínico para analisar a toxicidade do chá das folhas de Morus nigra L. (Moraceae). A toxicidade subcrônica do chá (CFMn) foi avaliada durante 30 dias por via oral em ratos. Ao grupo controle foi administrado água, para comparação. Durante o período experimental foi avaliada a presença de sinais de toxicidade, variação do peso corporal, e o consumo de líquido e alimento. Ao final do experimento o sangue dos animais foi retirado para análise de parâmetros hematológicos e bioquímicos. Não foram observados mortalidade e sinais de toxicidade indicando baixa toxicidade da planta. Não houve alterações nos parâmetros hematológicos e bioquímicos. Nas condições do estudo, o CF-Mn pode ser considerado de baixa toxicidade, pois não produziu efeitos tóxicos nos animais tratados. . The subchronic toxicity of this tea (CF-Mn) was orally evaluated during 30 days in rats. The control group was given water for comparison. During the experimental period, signs of toxicity, body weight variation, and water and food consumption were assessed. At the end of the experiment, the blood of animals was removed for analysis of hematological and biochemical parameters. No mortality and no toxicity signs were observed, indicating low toxicity of the plant. There was no alteration in the hematological and biochemical parameters. Under the study conditions, CF-Mn can be considered of low toxicity since it did not produce toxic effects in treated animals. Palavras

Effects of <i>Pereskia aculeata</i> Miller on the Biochemical Profiles and Body Composition of Wistar Rats

“…Other studies that examined the effect of plants on glycemiain Wistar rats reported similar results, such as that of Oliveira et al (2013) [29], who evaluated the subchronictoxicity of Morusnigra L. tea leaves in rats and found that this plant produced the expected hypoglycemic effect, since there was no significant difference in blood glucose levels. On the other hand, there are numerous plants that have a beneficial effect onglycemia.…”

Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra leaves extract

“…The leaves are used traditionally for therapeutical purposes as for the treatment of diabetes, hypercholesterolemia, menopause and obesity (Oliveira et al 2013, Silva and Naves 2001, Volpato et al 2011, Miranda et al 2010. Moreover, Volpato et al (2011) studied antihyperglicemic effect from Morus nigra leaf decoction in pregnancy diabetic rats although, obtained positive effects only in lipids levels.…”

Effect of ovarian tissue storage in Morus nigra extract on the morphology and DNA fragmentation of ovine preantral follicles

“…Nevertheless, a recent study demonstrated that the administration of M. nigra did not exhibit any estrogenic activity nor did exert a toxic effect on the female reproductive system and on the embryonic development of rats (QUEIROZ et al, 2012). Moreover, no biochemical and macroscopic changes were observed after 30 days of M. nigra administration in rats, thus demonstrating its low toxicity (OLIVEIRA et al, 2013).…”