Atividade antiulcerogênica do extrato aquoso da Bryophyllum pinnatum (Lam.) Kurz

Braz, D.C.; Oliveira, L.R.S.; Viana, Ana Flávia Seraine Custódio

doi:10.1590/s1516-05722013000100012

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…A previous study with methanolic extract (20 mg/kg and 40 mg/kg) in an ulcer model induced by indomethacin demonstrated inhibition indices of 49.39% and 71.08%, respectively (Adesanwo et al, 2007). In contrast to this study, other studies using an aqueous extract (1 g/kg and 2 g/kg) in an indomethacin model and a methanolic fraction (100 mg/kg and 300 mg/ kg) in an ulcer-induction ethanol model of leaves from K. pinnata showed the inhibition of gastric lesions by 45.49% and 49.50% and 37.5% and 54.2%, respectively (Pal, Chaudhuri, 1991;Braz, Oliveira, Viana 2013). However, our results showed that the ethyl acetate fraction displayed superior antiulcer activity by 50% at a dose of 200 mg/kg.…”

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confidence: 94%

“…The leaves of this plant are reported to possess wound healing (Nayak, Marshall, Isitor, 2010), anti-inflammatory (Ferreira et al, 2014), antioxidant (Hazarika et al, 2012), antimicrobial (El Abdellaoui et al, 2010 and antileishmanial properties (Muzitano et al, 2006a). Pal, Chaudhuri (1991), Adesanwo et al, (2007) ;Braz, Oliveira, Viana (2013) have reported the antiulcer activity of the methanolic fraction and the methanol and aqueous extract of K. pinnata. Phytochemical investigations have shown the presence of tannins, alkaloids and saponins (Biswas et al, 2011), bufadienolides (Yamagishi et al, 1989) and, mainly, flavonoids (Fürer et al, 2013) …”

Section: Introductionmentioning

confidence: 99%

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Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Sobreira

Hernandes

Vetore-Neto

et al. 2017

Braz. J. Pharm. Sci.

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Peptic ulcers are an important pathology, and the search for safer and more effective treatment methods is of paramount importance. In this study, we assess the gastroprotective effects of the hydroethanolic extract (HE) and ethyl acetate fraction (EAF) from Kalanchoe pinnata leaves against an ethanol/HCl-induced ulcer model in rats. The HE reduced gastric lesions by approximately 47% (400 mg/kg). A significant inhibition of the gastric lesions by 50% was observed after pretreatment with the EAF (200 mg/kg). Quercetrin and quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside were isolated and identified in the flavonoid fraction (EAF) by HPLC and NMR analyses because this fraction showed the highest gastroprotective effect. This fraction demonstrated high antioxidant activities (CE 50 =41.91 µg/mL) by DPPH in comparison with Trolox ® and 11.33 mmol Trolox ® equivalent by ORAC. In conclusion, the HE and FAE from K. pinnata displayed gastroprotective activity in rats, most likely due to the presence of flavonoids.Uniterms: Gastric ulcer/study/rats. Gastric ulcer/treatment. Kalanchoe pinnata/chromatographic profile. Kalanchoe pinnata/gastroprotective activity. Quercetrin. Quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside. INTRODUCTIONFor the past two centuries, peptic ulcers have caused high morbidity and mortality (Malfertheiner, Chan, Mccoll, 2009). This disease is a serious and prevalent pathology (Calam, Baron, 2001). A peptic ulcer is a chronic lesion, usually single, that can be located in the gastric or duodenal mucosae (Kumar, Abbas, Fausto, 2005). In the UK, the incidence of this disease was 12% higher in men than in women (Araujo, Borini, Guimarães, 2014). A review article (January 1980 to February 2009 showed that the incidence rate of uncomplicated peptic ulcers was approximately one case per 1000 people per year in the general population; the incidence rate for complicated peptic ulcers that included bleeding and perforation was approximately 0.7 cases per 1000 people per year (Lin, Rodrígues, Hernándes-Diaz, 2011).The pathophysiology of peptic ulcers suggests that this disease is caused by an imbalance between defensive factors (mucus and bicarbonate secretion, mucosal barrier, blood flow, and prostaglandins) and destructive factors (reactive oxygen species and acid and pepsin secretion), resulting in the acute inflammation of the gastrointestinal mucosae (Laine, Takeuchi, Tarnawski, 2008). Several stimuli serve as offensive factors, including Helicobacter pylori, the use of nonsteroidal anti-inflammatory drugs (NSAIDs), stress, alcohol and cigarette smoking (Malfertheiner, Chan, Mccoll, 2009;Malnick et al., 2014). The current medical treatment for peptic ulcers is generally based on proton pump inhibitors and histamine H 2 -receptor blockers (Jain et al., 2007). However, the long-term use of these therapeutic agents can produce adverse effects, such as hypergastrinemia and hyperplasia in the enterochromaffinlike (ECL) cells, the risk of pneumonia, diarrhea and the disturbance of ...

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confidence: 94%

Section: Introductionmentioning

confidence: 99%

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Sobreira

Hernandes

Vetore-Neto

et al. 2017

Braz. J. Pharm. Sci.

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“…Our results show preclinical evidence of the effect of these extracts as gastroprotectors. Previous studies reported in literature (using different extraction method) have demonstrated that the K. pinnata species presents gastroprotective activity [ 40 , 41 , 42 , 43 , 44 ] as well as only one study reported the gastroprotective activity of K. brasiliensis [ 45 ]. It is worth noting that when comparing our study with others described previously, we used an extraction method to obtain the leaf juices according to popular medicine without the use of toxic solvent.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats

Araújo

Guerra

Araújo

et al. 2018

IJMS

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Kalanchoe brasiliensis and Kalanchoe pinnata are used interchangeably in traditional medicine for treating peptic ulcers and inflammatory problems. In this context, this study aims to characterize the chemical constituents and evaluate the gastroprotective activity of the leaf juices of the two species in acute gastric lesions models. Thin Layer Chromatography (TLC) and Ultra High Performance Liquid Chromatography coupled to Mass Spectrometer (UHPLC-MS) were performed for chemical characterization. Wistar rats were pre-treated orally with leaf juices (125, 250 and 500 mg/kg) or ranitidine (50 mg/kg). The peaks observed in the chromatogram of K. brasiliensis showed similar mass spectra to flavonoid glycosides derived from patuletin and eupafolin, while K. pinnata showed mass spectra similar to compounds derived from quercetin, patuletin, eupafolin and kaempferol. K. brasiliensis at all doses and K. pinnata at doses of 250 mg/kg and 500 mg/kg significantly reduced the lesions in the ethanol induction model. In the indomethacin induction model, both species showed significant results at doses of 250 and 500 mg/kg. Also, the pre-treatment with leaf juices increased the antioxidant defense system, glutathione (GSH), whereas malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) levels were significantly decreased. Treatment with leaf juices led to the upregulation of zone occludes-1 (ZO-1) and the downregulation of inducible nitric oxide synthase (iNOS) and factor nuclear-κβ transcription (NF-κB-p65), while also showing a cytoprotective effect and maintaining mucus production. These findings show that the leaf juices of the two species showed gastroprotective effects on ethanol and gastric indomethacin injury which were a consequence of gastric inflammation suppression, antioxidant activity and the maintenance of cytoprotective defenses and mucosal structure architecture.

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“…Furthermore, most synthetic drugs for treatment are associated with undesirable side effects [3,4]. Several studies indicate the efficacy of medicinal plants for the peptic ulcer treatment, because of the presence of bioactive phytochemicals such as flavonoids, alkaloids, terpenes, tannins, saponins, phenolic acids, and others [2,5].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profile and gastroprotective potential of Myrcianthes pungens fruits and leaves

Almeida

Beleza

Campos

et al. 2017

Nutrire

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Background: The last decade has been marked by increasing data regarding gastroinstestinal diseases, specially gastritis and ulcer. In order to prevent or treat these diseases, many studies have demonstrated the potential of medicinal plants. The aim of this study was to evaluate the phytochemical profile and the gastroprotective activity of the methanolic extract of Myrcianthes pungens whole fruit, peel, pulp, seeds, and leaves. Methods: The methanolic extracts were analyzed by thin layer chromatography (TLC) to detect the presence of phenolic compounds by direct comparison with an authentic sample. To evaluate the gastroprotective activity, two experimental models were used: acute ulcer model induced by ethanol/HCl and acute ulcer model induced by nonsteroidal anti-inflammatory drug (indomethacin). Animals were divided in different groups (n = 6) and pretreated orally with the methanolic extracts of M. pungens at doses of 50, 125, and 250 mg/kg, the positive control (cimetidine 100 mg/kg) and negative control (distilled water). Results: The TLC analysis indicated the presence of the flavonoids quercetin and quercitrin in the leaves, quercetin in the peel, and catechin and epicatechin in the leaves and seeds of M. pungens. The extracts of leaves, peel, and pulp showed significant gastroprotective potential regarding the relative area of the lesion observed only in acute ulcer model induced by ethanol. The extracts of whole fruit, peel, pulp, seeds, and leaves showed significant gastroprotective potential observed in acute ulcer induced by indomethacin model. Conclusions: The gastroprotective activity can be related with the presence of some phenolic compounds identified in phytochemical analysis.

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Atividade antiulcerogênica do extrato aquoso da Bryophyllum pinnatum (Lam.) Kurz

Cited by 15 publications

References 13 publications

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.

Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats

Phytochemical profile and gastroprotective potential of Myrcianthes pungens fruits and leaves

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