Divergência genética entre acessos de espinheira-santa (Maytenus ilicifolia Mart. ex Reissek e M. aquifolium Mart.) com base em caracteres morfológicos e fisiológicos

Mariot, Márcio Paim; Barbieri, Rosa Lía

doi:10.1590/s1516-05722010000300001

Cited by 8 publications

(3 citation statements)

References 3 publications

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“…19 Among the species with the highest number of registration entries is M. ilicifolia, a plant species native to Brazil that has a high medicinal value due to its ability to treat gastritis and gastric ulcers. 20 In vitro, M. ilicifolia has been shown potently inhibit the proliferation of cytotoxic leukaemia cells (HL-60). 12 However, it has not previously been investigated whether M. ilicifolia modulates an apoptotic pathway in colorectal and hepatocellular cancer cells.…”

Section: Discussionmentioning

confidence: 99%

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Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells

Júnior

Oliveira

Pessoa

et al. 2013

Exp Biol Med (Maywood)

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Maytenus is the largest genus of the family Celastraceae and the species Maytenus ilicifolia (popularly known as 'Espinheira Santa'). It is widely used in traditional Brazilian medicine to treat stomach conditions including nausea, gastritis, and ulcers. In this study, the apoptotic effects of a spray-dried extract of M. ilicifolia (SDEMI) was evaluated using human hepatocellular cells (HepG2), colorectal carcinoma cells (HT-29), and normal keratinocytes (HaCaT). Cells were treated with SDEMI for 4 and 24 h, then were assayed for levels of apoptosis, caspase-3, and Bcl-2 by flow cytometry, immunostaining, and Western blot, respectively. Significant differences between groups were determined using analysis of variance (P < 0.05). For HepG2 and HT-29 cells treated with SDEMI, various cytotoxic effects were observed compared with control cells at all timepoints assayed (P < 0.001). Furthermore, positive caspase-3 staining and down-regulation of Bcl-2 were observed, consistent with the induction of cell death detected in these cell lines. In contrast, treatment of HaCaT cells with SDEMI was associated with a protective effect compared with control cells at both timepoints (P < 0.001). For example, increased expression of Bcl-2 and negative caspase-3 staining were detected. Taken together, these results suggest that SDEMI protects normal cells, while SDEMI mediates induction of apoptosis via down-regulation of Bcl-2 and involvement of caspase-3 in human carcinoma cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells

Júnior

Oliveira

Pessoa

et al. 2013

Exp Biol Med (Maywood)

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“…For example, the case of “espinheira santa” ( Maytenus ilicifolia ), which following its long-term indiscriminate harvesting became a threatened species [109] and is associated with several substitute species that currently occupy the same semantic-therapeutic niche [110]. …”

Section: Discussionmentioning

confidence: 99%

The “Hidden Diversity” of Medicinal Plants in Northeastern Brazil: Diagnosis and Prospects for Conservation and Biological Prospecting

Cavalcanti

Albuquerque

2013

Evidence-Based Complementary and Alternative Medicine

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Increases in ethnobotanical studies and knowledge in recent decades have led to a greater and more accurate interpretation of the overall patterns related to the use of medicinal plants, allowing for a clear identification of some ecological and cultural phenomena. “Hidden diversity” of medicinal plants refers in the present study to the existence of several species of medicinal plants known by the same vernacular name in a given region. Although this phenomenon has previously been observed in a localized and sporadic manner, its full dimensions have not yet been established. In the present study, we sought to assess the hidden diversity of medicinal plants in northeastern Brazil based on the ethnospecies catalogued by local studies. The results indicate that there are an average of at least 2.78 different species per cataloged ethnospecies in the region. Phylogenetic proximity and its attendant morphological similarity favor the interchangeable use of these species, resulting in serious ecological and sanitary implications as well as a wide range of options for conservation and bioprospecting.

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Phytochemistry and Pharmaceutical Technology Studies on Monteverdia ilicifolia (Maytenus ilicifolia): a Traditionally Used Medicinal Plant

Meirelles

Bianchi

Siqueira

et al. 2022

Rev. Bras. Farmacogn.

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Divergência genética entre acessos de espinheira-santa (Maytenus ilicifolia Mart. ex Reissek e M. aquifolium Mart.) com base em caracteres morfológicos e fisiológicos

Cited by 8 publications

References 3 publications

Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells

Maytenus ilicifolia dry extract protects normal cells, induces apoptosis and regulates Bcl-2 in human cancer cells

The “Hidden Diversity” of Medicinal Plants in Northeastern Brazil: Diagnosis and Prospects for Conservation and Biological Prospecting

Phytochemistry and Pharmaceutical Technology Studies on Monteverdia ilicifolia (Maytenus ilicifolia): a Traditionally Used Medicinal Plant

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