Recurrencias de malaria por Plasmodium vivax según el uso de primaquina: análisis de estudios descriptivos longitudinales

Abstract

Although not 100%, PQ is effective in preventing recurrence. Total doses of 210 and 75 mg are equally effective, but 75 mg alone has been evaluated in India, where P. vivax seems to respond better to PQ than elsewhere. The effect of place in the proportion of recurrences seems evident, even using the same total dose. The role of follow-up time is not clear. Although the standard regimen has an average effectiveness of 90% or more, alternative regimens should be assessed.

Primaquina y recurrencias de malaria por Plasmodium vivax. Metanálisis de estudios clínicos controlados

“…In Cochrane Infectious Diseases Group, we found the same as in Cochrane Library. In PubMed we found review articles and meta-analysis ones; in both cases, many references were obtained 5,6,[13][14][15] . The search in Scholar Google yielded 94 results; the titles in the writings were compared to the ones obtained in all other sources, but it resulted in no new reference which would meet the inclusion criteria.…”

“…The meta-analysis on the effectiveness of PQ against vivax recurrences, according to the longitudinal descriptive field studies 5 , showed that the TD of 210 and 75 mg had the same effectiveness, but 75 mg had only been evaluated in India, where P. vivax seems to be more sensible to PQ than in other places. The meta-analysis of the CCTs presented here show that 210-14 is better than 45 to 150 in 3 to 10 days (including TD 75) and that 45 to 150 is similar to using no PQ.…”

“…The alkylation of the amine group in position eight with a lateral chain of five carbons and a terminal amine confers it with great power [1][2][3][4][5][6] . PQ seems more efficient when it occurs simultaneously with the blood schozonticides 2 and, from all antimalarials, this is the one which has the wider activity spectrum 3 .…”

“…PQ seems more efficient when it occurs simultaneously with the blood schozonticides 2 and, from all antimalarials, this is the one which has the wider activity spectrum 3 . The PQ has proven highly useful for simple primary and secondary chemoprophylaxis 4 or against recurrences [5][6][7][8] . The total dosis (TD) of 210 mg given in 14 days (210-14), for an adult weighting 60 kg (0.25 mg/kg/day for 14 days), is recommended by the WHO as the stardard in order to avoid recurrences 7 .…”

“…The clinical and parasitary cure, which include avoiding recurrences of the infection by P. cynomolgi and P. vivax is the role of the TD of the 8-AQ 9,10 . There are several recent reviews on the use of PQ to avoid the recurrences 3,11,12 , as well as meta-analysis on the theme 5,6,[13][14][15] . The 2 meta-analysis of Cochrane 6,13 assessed random and semi-random controlled clinical trials (CCT) in humans who compared treatments with chloroquine only against chloroquine added with PQ, given as 210-14, and other PQ schemes.…”