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Background and Objectives:Occupational stress can be related to the emergence of physical and mental illnesses. The objective is to evaluate the association between the psychosocial aspects of work, according to the Demand-Control Model, and the occurrence of mental disorders among workers of the Family Health Strategies in Santa Cruz do Sul, RS. Methods: This was a cross-sectional and quantitative study carried out with an epidemiological approach. The study target population consisted of 89 professionals, including doctors, nurses, nursing technicians/assistants (NT) and community health workers, who comprised 11 Family Health Strategy teams in the city of Santa Cruz do Sul. We used a questionnaire containing sociodemographic, occupational, and other questions from the Job Stress Scale and the Self-Reporting Questionnaire. Results: It was found that 30.1% of the professionals showed high levels of demand and low job control, resulting in high exposure to the development of occupational stress. The prevalence of common mental disorders in professionals submitted to high strain jobs was 38%. Conclusions: Considering these results are of concern, it is necessary to take attitudes aimed at preventing or reducing work-related stress and illnesses at work.