Formação do esmalte dentário, novas descobertas, novos horizontes

Molar Incisor Hypomineralization: Morphological, Aetiological, Epidemiological and Clinical Considerations

“…The etiology of MIH as a result of synergistic action of environmental factors and, suddenly genetic expressions leaving disturbances in enamel formation of molars and incisors in the first year of life, is the challenge to be overcome. Ultimately, the discovery of new genes and novel proteins such as amelotin and apin (Nishio, 2008) that they are also produced by ameloblasts, but during the stage of maturation, with important enamel mineralization function in relation to obtaining final hardness of enamel point to a promissory future in relation to knowledge of dental development. Well-being, understanding the genetic sequential and signaling pathways of developmental normal of enamel will provide us with an invaluable tool for understanding the pathways and mechanisms of tissue maintenance, repair and regeneration.…”

Expression of odontogenic ameloblast‐associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations

“…The epithelial cells of JE also secrete this protein as a line at the interface with the enamel (14). Despite the similar interfacial detection of AMTN and ODAM, the later is distinctive in that it is also present among the cells of the JE (4, 8, 14).…”

“…ODAM persists throughout the maturation stage and is also expressed by the squamous cells forming the junctional epithelium (JE), which confirms the JE histogenesis from the REE. ODAM gene expression is upregulated in the CEOT, cervix cancer, gastric cancer, epithelial cells rests of Malassez (4–12). Solomon et al.…”