Metabolic abnormalities and overweight in HIV/AIDS persons-treated with antiretroviral therapy

Leite, Luísa Helena Maia; Sampaio, Aline da Graça

doi:10.1590/s1415-52732008000300002

Cited by 16 publications

(18 citation statements)

References 17 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found that the prevalence of excess weight (overweight or obesity) was high and greater than the prevalence of malnutrition among HIV/AIDS patients, findings that agree with other studies (13,16,17,21). We found similar frequencies of overweight in women and men.…”

Section: Discussionsupporting

confidence: 91%

“…Other studies also reported high frequency of overweight and obesity, and a positive association between these problems and being female (14,15). This was also observed in studies conducted in Brazil, which have shown high prevalence of overweight and obesity among HIV-positive patients (16)(17)(18).…”

supporting

confidence: 57%

“…The significance level was set at 5% (p < 0.05). We used the Statistical Package for Social Science (SPSS) software, version 17.0, to analyze the data. Odds ratio was calculated by EpiInfo 6.4.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of obesity and cardiovascular risk in patients with HIV/AIDS in Porto Alegre, Brazil

Kroll

Sprinz

Leal

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Objective: The aim of this study was to discover the prevalence of overweight, obesity and cardiovascular risk in our HIV/AIDS outpatients according to sex, antiretroviral therapy and other variables. Subjects and methods: Patients underwent an anthropometric assessment. Body mass index and waist circumference were used to classify their nutritional status and their cardiovascular risk. Results: The majority of the 345 patients (58.8%) were males. Obesity was detected in 8.3% of them; 34.2% were overweight, and 5.2% malnourished. Near half of them (51.3%) had some cardiovascular risk, with increased risk in 24.6% of them, and substantially increased risk in 26.7% of them. Conclusions: Overweight and obesity were highly prevalent. Women were more frequently obese (OR = 3.53; IC 95%, 1.47 < OR < 8.69), and their cardiovascular risk was often higher (OR = 6.97; IC 95%, 4.16 < OR < 11.76). The prevalence of obesity and cardiovascular risk did not change according to antiretroviral therapy or other variables. Arq Bras Endocrinol Metab. 2012;56(2):137-41 Keywords Overweight; obesity; body mass index; HIV; acquired immunodeficiency syndrome RESUMO Objetivo: Conhecer a prevalência de sobrepeso, obesidade e risco cardiovascular em nossos pacientes ambulatoriais com HIV/AIDS de acordo com o sexo, tratamento antirretroviral e outras variáveis. Sujeitos e métodos: Os pacientes foram submetidos à avaliação antropométri-ca. O índice de massa corporal e a medida da circunferência da cintura foram utilizados para classificar o estado nutricional e o risco cardiovascular. Resultados: A maior parte dos 345 pacientes (58,8%) era do sexo masculino. A obesidade foi detectada em 8,3% deles; 34,2% tinham sobrepeso e 5,2%, desnutrição. Quase a metade (51,3%) apresentou algum risco cardiovascular, com risco elevado em 24,6% e muito elevado em 26,7%. Conclusões: O sobrepeso e a obesidade têm elevada prevalência. As mulheres são mais frequentemente obesas (OR = 3,53; IC 95%, 1,47 < OR < 8,69) e seu risco cardiovascular é frequentemente mais alto (OR = 6,97; IC 95%, 4,16 < OR < 11,76). A prevalência de obesidade e de risco cardiovascular não se alterou conforme o tratamento antirretroviral ou outras variáveis. Arq Bras Endocrinol Metab. 2012;56(2):137-41 Descritores

show abstract

Section: Discussionsupporting

confidence: 91%

supporting

confidence: 57%

See 1 more Smart Citation

Prevalence of obesity and cardiovascular risk in patients with HIV/AIDS in Porto Alegre, Brazil

Kroll

Sprinz

Leal

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…The present study found more altered mean values of TC, TG, LDL and glycemia when compared to the ones of a national study carried out in Rio de Janeiro, which assessed 203 seropositive patients 22 .…”

Section: Rev Bras Epidemiol Jul-set 2017; 20(3): 526-536contrasting

confidence: 68%

Redistribuição de gordura corporal e alterações no metabolismo de lipídeos e glicose em pessoas vivendo com HIV/AIDS

Beraldo

Santos

Guimarães

et al. 2017

Rev. bras. epidemiol.

View full text Add to dashboard Cite

Introduction:The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART). Objective: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART. Methods: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC). For the lipodystrophy evaluation we conducted physical examination (subjective) and the (objective) examination of absorptiometry with X-ray dual energy (DEXA) by fat mass ratio (FMR). We also conducted lipid profile tests and fasting glucose and used the criteria suggested by The National Cholesterol Education Program III for metabolic disorders classification. Results: The final sample consisted of 262 patients with a mean age of 44.3 ± 10.2 years. Lipodystrophy, according to the physical examination, was present in 47.7% (95%CI 41.7 -53.8) of patients, while the prevalence using FMR (DEXA) was 40.8% (95%CI 33.1 -48.5). Most (53.0%; 95%CI 47.0 -59.1) of the patients showed increased abdominal adiposity according to AC. The most prevalent metabolic alterations were reduced HDL (67.6%; 95%CI 61.9 -73.2) and hypertriglyceridemia (55.7%; 95%CI 49.7 -61.7). Conclusion: The high prevalence of lipodystrophy and changes in lipid and glucose metabolism show the importance of early intervention in this group of patients to prevent cardiovascular complications.

show abstract

“…The authors observed changes in the nutritional profile of individuals with HIV since the introduction of HAART, with an increasing prevalence of obesity and a decrease in thinness. Other studies also have shown that the BMI of people living with HIV/AIDS do not differ from those of the general population [14][15][16]. The difference in the study might be that some of HIV-infected pregnant women might be under stress compounded by their poor nutritional and socioeconomic status.…”

Section: Discussionmentioning

confidence: 78%

Possible Changes in Maternal Plasma Cortisol, AdrenocorticotropicHormones, Pregnancy Associated Plasma Protein-A and Alpha-fetoproteinin HIV Pregnant Women at NAUTH Nnewi, Nigeria

Ukibe¹,

Onyenekwe²,

Anojulu³

et al. 2015

J Bioanal Biomed

View full text Add to dashboard Cite

Background: There is limited information on if HIV infection induces stress in pregnancy. HIV can possibly contribute to the alterations in some fetal viability hormones thereby lead to adverse pregnancy outcome. The present study aimed to assess the possible changes in maternal cortisol, Adrenocorticotropic (ACTH), Pregnancy associated plasma protein-A (PAPP-A) and alpha-fetoprotein (AFP) hormone concentrations in HIV-infected pregnant women and their pregnancy outcomes. Methods:A cross sectional study of 80 (Eighty) volunteer pregnant women aged (18-49) years recruited during routine antenatal clinics in Nnamdi Azikiwe Teaching Hospital, Nnewi, Anambra State, Nigeria was conducted. The participants were divided into groups: 40 (forty) apparently healthy pregnant and 40 (forty) HIV-infected pregnant women. 5 ml of morning blood samples were collected from each subject in their 1 st and 2 nd trimesters for estimation of Cortisol, ACTH, AFP and PAPP-A using ELISA method. Results:The result showed that the mean systolic and diastolic blood pressures (mmHg) of HIV pregnant women were significantly higher than control (p<0.05 respectively). The mean value of cortisol (ng/ml) in HIV pregnant women was significantly higher when compared with control subjects (p<0.05). Cortisol showed inverse significant correlation with AFP in HIV-infected pregnant women. Maternal outcomes showed thatt HIV-infected pregnant women had significantly higher incidence of miscarriages and preeclampsia with higher incidence of perinatal outcomes such as low birth weight babies (LBW), preterm delivery, spontaneous abortion, still birth and low Apgar scores when compared with apparently normal pregnant women (P<0.05 respectively).Conclusion: the significantly higher cortisol level and BP in HIV pregnant women is indicative of oxidative stress due to perceived stress by HIV infection which might predispose the affected women to hypertension and preeclampsia. The highest adverse reactions observed in HIV pregnant women might be related to the damaged immune system by HIV infection however, the placental defect associated with increased placental permeability to AFP and the activity of the insulin-like growth factor (IGF) system is not related to the activity of stress thereby do not influence their birth outcomes.

show abstract

Metabolic abnormalities and overweight in HIV/AIDS persons-treated with antiretroviral therapy

Cited by 16 publications

References 17 publications

Prevalence of obesity and cardiovascular risk in patients with HIV/AIDS in Porto Alegre, Brazil

Prevalence of obesity and cardiovascular risk in patients with HIV/AIDS in Porto Alegre, Brazil

Redistribuição de gordura corporal e alterações no metabolismo de lipídeos e glicose em pessoas vivendo com HIV/AIDS

Possible Changes in Maternal Plasma Cortisol, AdrenocorticotropicHormones, Pregnancy Associated Plasma Protein-A and Alpha-fetoproteinin HIV Pregnant Women at NAUTH Nnewi, Nigeria

Contact Info

Product

Resources

About