The lactase persistence genotype is a protective factor for the metabolic syndrome

Abstract

The Metabolic Syndrome (MetS) is defined as a pattern of metabolic disturbances, which include central obesity, insulin resistance and hyperglycemia, dyslipidemia, and hypertension. Milk has been promoted as a healthy beverage that can improve the management of MetS. Most human adults, however, down-regulate the production of intestinal lactase after weaning. Lactase encoded by the LCT gene is necessary for lactose digestion. The -13910C > T SNP (rs4988235) is responsible for the lactase persistence phenotype in European populations. We herein investigated whether the lactase persistence genotype is also associated with the MetS in subjects from a Brazilian population of European descent. This study consisted of 334 individuals (average age of 41 years) genotyped by PCR-based methods for the -13910C > T SNP. Clinical data were assessed and the genotypes were tested for their independent contribution to the MetS using chi-square tests and multiple logistic regression analysis. Univariate analyses showed that hypertension and MetS prevalence were higher in individuals with the lactase non-persistence genotype than in lactase persistence subjects. Furthermore, lactase persistence was associated with a lower risk for MetS (OR = 0.467; 95% CI 0.264–0.824; p = 0.009). These results suggest that LCT genotypes can be a valuable tool for the management of MetS treatment.

Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis

“…For binary outcomes, combining CT and TT into a single group and/or estimating the necessary statistics was performed when necessary, 30 , 44 , 48 , 50 , 53 based on number of individuals belonging to each outcome-LP status combination, as presented in the publications.…”

Lactose intolerance and its association with the exogamy degree among the population of eastern Ukraine

“…Аналіз результатів показав, що фенотип лактозної толерантності трапляється у 69,5 % жителів регіону, що відповідає даним іншими за європейськими країнами: 0,71 -у жителів Франції, 0,64 -в Естонії, 0,63 -у Польщі [3].…”

“…Географічний розподіл ЛТ у людських популяціях відповідає історичному існуванню галузі молочного скотарства у відповідних регіонах. У європейських країнах два однонуклеотидних поліморфізми-13910C-T (rs4988235) та 22018G-A (rs182549), розташовані в гені MCM6, регулюють лактозну толерантність і гіполактазію [3]. Зв'язок лактозної непереносимості (ЛН) з мінеральною щільністю кісткової тканини, ризиком переломів та остеопорозом є одним з основних обговорюваних питань, пов'язаних із можливістю засвоювати лактозу.…”

“…1 , BABALIAN V. 2 , BOROZENETS V. 1 , MAZNIAKOV S. 2 , PUZIK N. 1, 3 1 V.N. Karazin Kharkiv National University, Ukraine, 61058, Kharkiv, Svoboda sq., 4, е-mail: amsfedota@gmail.com 2 Kharkiv Medical Academy of Postgraduate Education, Ukraine, 61176, Kharkiv, Amosovast, 58, е-mail: babalyanvladimir@gmail.com 3 Kharkiv National Medical University, Ukraine, 61022, Kharkiv, Nauky Avenue, 4, е-mail: n.g.lysenko@gmail.com…”

Complex Interactions of Obesity, Dairy Food Intake and Genetics of Lactase

“…Other publications do not support a specific deleterious effect of lactase persistence or a protective effect of lactase non persistence against obesity. In fact the dominant lactase persistence genotype was found to be protective for obesity [92]. A study from Luxembourg reported in an observational format a protective effect of total dairy food intake, despite whole fat content against obesity and cardiovascular disease [93].…”