Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population

Abstract

Polymorphisms in the regulatory region of the CCR5 gene affect protein expression and modulate the progress of HIV-1 disease. Because of this prominent role, variations in this gene have been under differential pressure and their frequencies vary among human populations. The CCR2V64I mutation is tightly linked to certain polymorphisms in the CCR5 gene. The current Omani population is genetically diverse, a reflection of their history as traders who ruled extensive regions around the Indian Ocean. In this study, we examined the CCR2-CCR5 haplotypes in Omanis and compared the patterns of genetic diversity with those of other populations. Blood samples were collected from 115 Omani adults and genomic DNA was screened to identify the polymorphic sites in the CCR5 gene and the CCR2V64I mutation. Four minor alleles were common: CCR5-2554T and CCR5-2086G showed frequencies of 49% and 46%, respectively, whereas CCR5-2459A and CCR5-2135C both had a frequency of 36%. These alleles showed moderate levels of heterozygosity, indicating that they were under balancing selection. However, the well-known allele CCR5Δ32 was relatively rare. Eleven haplotypes were identified, four of which were common: HHC (46%), HHE (20%), HHA (14%) and HHF*2 (12%).

Genetic Diversity within Chemokine Receptor 5 (CCR5) for Better Understanding of AIDS

“…We also performed a linkage disequilibrium (LD) pattern to classify polymorphisms on the CCR5 gene. Eleven haplotypes were constructed; three of them were new: HHC*A, HHF*1A, and HHF*2A [35]. The results of both studies indicated that the one ethnic Omani population is genetically quite diverse when compared with other Asian populations such as Thais [36].…”