Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids

Guimarães, Larissa Oliveira; Andrade, Fabiana Antunes; Bono, Gleyse Freire; Setoguchi, Thaís E.; Brandão, Mariana B.; Chautard‐Freire‐Maia, Eleidi A.; Santos, Izabella C.R. dos; Picheth, Geraldo; Faria, Ana Cristina R. de A.; Réa, Rosângela Roginski; Souza, Ricardo Lehtonen Rodrigues de; Furtado-Alle, Lupe

doi:10.1590/s1415-47572014000100003

Cited by 7 publications

(2 citation statements)

References 39 publications

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“…Similarly, it has been shown that long-term diabetes alters lipid metabolism with increasing BuChE activity [32]. On the other hand, during the gestational DM, BuChE activity is decreased [33]. Furthermore, a remarkable decrease in the BuChE activity was observed in retinas of STZ-induced diabetic rats [34] and following oxidative stress [35].…”

Section: Resultsmentioning

confidence: 99%

Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities

et al. 2016

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Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities

et al. 2016

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“…Human butyrylcholinesterase (BChE, EC 3.1.1.8) is a serum esterase synthesized by liver cells (Wescoe et al., ) that hydrolyzes several choline esters but uses butyrylcholine as its preferred substrate (Whittaker, ). BChE is encoded by the BCHE gene on 3q26.1‐q26.2 (Soreq et al., ; Allderdice et al., ; Gaughan et al., ) that has been associated to body mass index (BMI) (Souza et al., ; Furtado‐Alle et al., ), obesity (Alcântara et al., ; Chaves et al., ), and Gestational Diabetes Mellitus (Guimarães et al., ).…”

Section: Introductionmentioning

confidence: 99%

Association between RAPH1 Gene Haplotypes and CHE2 Locus Phenotypes

Andrade

Batistela

Amaral

et al. 2016

Annals of Human Genetics

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SummaryThe human butyrylcholinesterase (BChE) is a serum esterase that has been associated with body mass index (BMI) and obesity. Its activity is conditioned by alleles of BCHE gene and the CHE2 locus that codifies an unknown BChE-binding protein (C 5 complex). The hypothesis that the CHE2 locus is the RAPH1 gene, which encodes lamellipodin (Lpd), was raised in a study that observed Lpd peptides released from denatured BChE tetramers. The aim of this study was to test this hypothesis by evaluating SNPs of RAPH1 gene (rs2246118:C > T, rs3814365:A > G and rs2465520:C > T) in 34 CHE2 C5+ and 92 CHE2 C5-individuals, corresponding to the presence and absence of C 5 complex. The results showed association of two haplotypes (CAC and TGC) with CHE2 C5+ phenotype. RAPH1 haplotypes was also associated with intense (TGC) and faint (CAC) CHE2 C5+ phenotypes. BChE activity was higher in intense CHE2 C5+ than faint CHE2 C5+ phenotype. Our results corroborate the hypothesis that the RAPH1 gene is the CHE2 locus and suggest that the variable expressivity of the CHE2 C5+ phenotypes is, at least in part, due to its genetic heterogeneity, which is leading to increased BChE activity only in individuals with intense CHE2 C5+ phenotype.

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Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus

2015

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The aims of the present study were to explore serum levels of lipid profile, atherogenic indexes LDL-C/HDL-C, TG/HDL-C, and TC/HDL-C, bilirubin, adiponectin, pseudocholinesterase, activities of gamma-glutamyltransferase (GGT), adenosine deaminase (ADA), and α-amylase, insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR) formula, and assessment of correlations between them in gestational diabetes mellitus (GDM) compared with normal pregnancy. A cross-sectional study was designed. The patients consisted of 30 women with GDM. The normal group consisted of 30 healthy pregnant women. The Mann-Whitney U test and Spearman's correlation analysis were used for statistical analysis. A p value less than 0.05 was considered significant. Serum activities of enzymes GGT (p = 0.001) and ADA (p = 0.02) were significantly higher in GDM compared with normal pregnancy, while pseudocholinesterase were significantly decreased (p = 0.02). However, activity of enzyme α-amylase did not show significant difference between two groups (p = 0.75). Serum levels of both HDL-C and adiponectin were significantly decreased in GDM group (p = 0.001). The atherogenic indexes and the HOMA-IR index were significantly higher in GDM (p = 0.001). Serum activity of ADA showed positive correlation with total cholesterol (TC) (r = 0.46, p = 0.01) and CRP (r = 0.66, p = 0.001) in GDM group. Serum levels of total bilirubin correlated negatively with both ADA (r = -0.38, p = 0.04) and triglyceride (r = -0.45, p = 0.01) in women with GDM. Serum activity of GGT correlated positively with LDL-C (r = 0.48, p = 0.01) and TC (r = 0.52, p = 0.003) in GDM group. Increased atherogenic indexes, ADA, GGT, and decreased pseudocholinesterase might be risk factors for GDM.

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Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids

Cited by 7 publications

References 39 publications

Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities

Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities

Association between RAPH1 Gene Haplotypes and CHE2 Locus Phenotypes

Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus

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