Non-detection of Epstein-Barr virus and human papillomavirus in a region of high gastric cancer risk indicates a lack of a role for these viruses in gastric carcinomas

Yuan, Xiaoyan; Wang, Mingyi; Wang, Xiaoyan; Chang, A.M.Z.; Li, Jie

doi:10.1590/s1415-47572013005000018

Cited by 20 publications

(16 citation statements)

References 7 publications

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“…In addition, 15 studies provided the prevalence of HPV in different histological differentiations of patients with GC, which were divided into well-differentiated, moderately differentiated, poorly differentiated, and undifferentiated grades 16–30. Some studies provided concrete information about HPV prevalence in different clinical stages (TNM: I, II, III, and IV),16,19,27,31,32 the age and sex15,16,18,19,25,27,32 of the patients, and specific HPV types (HPV16 and HPV18) 15,16,20–24,29–31,33–39Table 1 provides the information about the studies.…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen studies provided data on specific HPV types (including HPV16 and HPV18) 15,16,20–24,29–31,33–39. HPV16 was found in 210 (21%) of the 992 GC cases, whereas HPV18 was found in 90 (7%) of the 992 GC cases, with a significant OR of 3.314 (95% CI: 1.617, 6.792).…”

Section: Resultsmentioning

confidence: 99%

“…Five studies provided concrete information about HPV prevalence in different clinical stages (TNM: I, II, III, IV) 16,19,27,31,32. The HPV prevalence was 51.0% (49 of 96 patients) in TNM I/TNM II GC patients and 40.6% (58 of 143 patients) in TNM III/TNM IV GC patients.…”

Section: Resultsmentioning

confidence: 99%

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Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Zeng¹,

Luo²,

Zou³

et al. 2016

OTT

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BackgroundHuman papillomaviruses (HPVs) are causally associated with the tumorigenesis of several classes of cancers. However, the prevalence of HPV in gastric cancer (GC) has not yet been systematically reviewed. Hence, a meta-analysis was conducted to estimate the HPV prevalence in patients with GC, and its potential etiologic significance was assessed.MethodsThe pooled HPV prevalence and 95% confidence intervals (CIs) were estimated among all GC patients. Heterogeneity was described by using the I2 statistic. Sources of heterogeneity were explored by meta-regression and stratified analyses. The meta-influence was applied to evaluate the influence of a single study on the pooled estimates. Odds ratios (ORs) and 95% CIs were computed for case–control studies. For research providing clinicopathological parameters of age, sex, pathological, differentiated, and clinical stages, and HPV subtypes, the corresponding pooled ORs and 95% CIs were also calculated.ResultsThirty studies were included in the current meta-analysis, involving 1,917 patients with GC and 576 controls. The pooled HPV prevalence was 28.0% (95% CI: 23.2%, 32.7%) among all the patients with GC, and the I2 was 96.9% (P<0.001). A pooled OR of 7.388 (95% CI: 3.876, 14.082) was achieved based on 15 case–control studies (I2=56.7%, P=0.004). Moreover, the HPV prevalence was significantly higher in patients from China than in those from non-Chinese regions (31% vs 9%, I2=95.0%, P<0.001). The pooled prevalence of HPV16 was 21% in GC tissues, and the pooled prevalence of HPV18 was 7% with an OR of 3.314 (95% CI =1.617, 6.792). HPV16 was 3 times more frequently detected than HPV18.ConclusionHPV could play a potential role in the pathogenesis of GC. A causal relationship can be confirmed only by detecting HPV in the cells of GC precursor lesions (gastric dysplasia or adenoma). In addition, this study might be beneficial for expounding the potential etiologic significance of molecular mechanism of gastric tumorigenesis and providing opinions regarding precautionary measures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Zeng¹,

Luo²,

Zou³

et al. 2016

OTT

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“…However, HPV-16 was the most common type identified in the upper digestive tract in a study reported by Xu et al (7). In addition, Yuan et al (19) did not detect HPV in gastric cancer in China. Erol et al (20) investigated 106 gastric cancer samples and identified HPV DNA in 33 cases.…”

Section: Discussionmentioning

confidence: 94%

Detection of human papillomavirus DNA in gastric carcinoma specimens in a high-risk region of Iran

et al. 2016

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Gastric cancer is the fourth most common type of cancer worldwide and is associated with high mortality rates. The incidence of gastric cancer varies widely in different geographical regions. For example, in Iran, the most northern and northwestern regions are considered to be high-risk areas for gastric cancer. The aim of the present study was to determine the distribution of human papillomavirus (HPV) genotypes among patients with gastric carcinoma in Mazandaran province, Northern Iran, which is a high-risk area. A total of 100 paraffin-embedded tissue samples were obtained from 70 males and 30 females with gastric carcinoma, diagnosed between 2006 and 2013, in the Imam Khomeini Hospital (Sari, Iran). GP5+/GP6+ general primers were applied for detection of HPV DNA in the specimens. Positive samples were then selected and high-risk HPV genotyping was performed. The samples were analyzed by polymerase chain reaction and five (5%) samples were identified to be positive for HPV DNA [four male (5.7%) and one female (3.3%)]. Three (60%) samples were positive for HPV-16, one (20%) sample was positive for HPV-18 and one (20%) sample was positive for HPV-45. Following pathological diagnosis, 88 samples were identified as gastric adenocarcinoma, nine samples were gastric lymphoma, and three samples were gastric and esophagus adenocarcinoma. According to the findings of the present study and the rate of HPV infection in patients with gastric carcinoma, an association between HPV infection and gastric carcinoma in subjects from Northern Iran was not identified.

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“…Viral E6 and E7 oncoproteins that inactivate tumor suppressor proteins p53 and retinoblastoma are required for malignant transformation, the net effect of HPV E6 and E7 proteins is to block apoptosis and remove the restrains to cell proliferation (10). a few studies have focused on the role of HPV in the development of gastric cancer, with controversial result, some indicate the presence of HPV especially type16 (11), while other rule out the presence of HPV in gastric cancer (12), (13), (14).The present study was designed to study the presence of HPV by employing immunohistochemical methods in gastric cancer sections.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Based Detection of HPV in Gastric Cancer among Sudanese Patient

Mohamed¹,

Elemam²,

Satti³

et al. 2016

Int.J.Curr.Res.Aca.Rev

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Screening for viruses is an essential step in the continuum of research that is expected to lead to new treatment strategies in patients with virus-positive tumors. This study aimed to demonstrate the presence of human papilloma virus (HPV) in gastric tumors The study involved 30 formalin fixed paraffin embedded blocks from patients with gastric tumors, collected during January 2014 and October2015.in histopathology departments of Omdurman teaching hospital, Khartoum, Sudan. The presence of HPV was determined using immunohistochemistry Among the 30 patients, 20 male (66.7%) and 10 female (33.3%) with (2:1) male: female ratio, only two samples (6.7%) were positive for HPV, while 28(93.3%) were negative. the pathogenic causative role of HPV infection in Sudanese patients with gastric cancer was not established.

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Non-detection of Epstein-Barr virus and human papillomavirus in a region of high gastric cancer risk indicates a lack of a role for these viruses in gastric carcinomas

Cited by 20 publications

References 7 publications

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

Detection of human papillomavirus DNA in gastric carcinoma specimens in a high-risk region of Iran

Immunohistochemical Based Detection of HPV in Gastric Cancer among Sudanese Patient

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