Comparison of HMOX1 expression and enzyme activity in blue-shelled chickens and brown-shelled chickens

Wang, Zhepeng; Liu, Ruifang; An-ru, Wang

doi:10.1590/s1415-47572013000200020

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Indeed, work by Wang et al. ( 2013 ) and Wragg et al. ( 2013 ) had identified expression of the SLCO1B3 gene in the uterus of the oviduct in Araucana as resulting in formation of blue eggshells.…”

Section: Impact Of Genetic Factors On Eggshell Color and Qualitymentioning

confidence: 99%

Recent advances in avian egg science: A review

Wilson

2017

Poultry Science

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Eggs and egg products form an integral part of the food chain. As such, research into egg structure, function, and production has made an important contribution to the field of poultry science. The past decade has seen significant advances in avian egg science research, with work supplementing our understanding of the nature of the avian egg, and its biological, chemical, and physical properties. Eggshell color, strength, and chemical composition, poultry nutrition, and genetics have all been intensively studied recently, with significant progress being made in a number of these areas. Indeed, with the prevalence of robust theoretical techniques, it is now commonplace to combine experimental investigations with theory, providing a balanced and interdisciplinary perspective.

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Section: Impact Of Genetic Factors On Eggshell Color and Qualitymentioning

confidence: 99%

Recent advances in avian egg science: A review

Wilson

2017

Poultry Science

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“…The molecular basis of brown pigment synthesis and its possible metabolic pathway in brown-egg laying hens need further exploration in order to determine the genes involved (Wang et al, 2013). The color of the eggshell is assumed to be controlled by several genes that encode proteins and enzymes, thereby regulating the production and deposition of pigment into the shell (Van Brummelen and Bissbort, 1993;, but the responsible genes in brown-egg laying hens are yet to be identified.…”

Section: Genetics Of the Eggshell Colormentioning

confidence: 99%

Eggshell color in brown-egg laying hens — a review

2015

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The major pigment in eggshells of brown-egg laying hens is protoporphyrin IX, but traces of biliverdin and its zinc chelates are also present. The pigment appears to be synthesized in the shell gland. The protoporphyrin IX synthetic pathway is well defined, but precisely where and how it is synthesized in the shell gland of the brown-egg laying hen is still ambiguous. The pigment is deposited onto all shell layers including the shell membranes, but most of it is concentrated in the outermost layer of the calcareous shell and in the cuticle. Recently, the genes that are involved in pigment synthesis have been identified, but the genetic control of synthesis and deposition of brown pigment in the commercial laying hen is not fully understood. The brown coloration of the shell is an important shell quality parameter and has a positive influence on consumer preference. The extent of pigment deposition is influenced by the housing system, hen age, hen strain, diet, stressors, and certain diseases such as infectious bronchitis. In this article, the physiological and biochemical characteristics of the brown pigment in commercial brown-egg layers are reviewed in relation to its various functions in the poultry industry.

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“…In addition, heme-oxygenase (HO) gene expression and enzyme activity in the shell gland was significantly higher in blue-than in brown-shelled chickens (Wang et al 2011). In contrast, in the spleen and liver, HO enzyme gene expression and activity showed no significant difference between blue-and brown-shelled chickens, suggesting that the origin of eggshell biliverdin is not the spleen or liver (Wang et al 2013). These results suggest that eggshell biliverdin pigment is most likely synthesized in the shell gland by heme oxidation, although it is not clear whether heme is derived from circulating red blood cells or is produced de novo in the cells of the shell gland.…”

Section: Introductionmentioning

confidence: 97%

“…Here, we experimentally studied the possible origin of biliverdin-and protoporphyrin-based eggshell pigmentation of domestic canaries (Serinus canaria). The canary is an ideal model species for this study because it lays eggs that vary in intensity of both blue-green and brown coloration, it can be easily kept and bred in captivity, and it has a different evolutionary history than the species studied so far (chickens, ducks; e.g., Zhao et al 2006;Liu et al 2010;Wang et al 2013). It is important to distinguish biliverdin-and protoporphyrinbased pigmentation, as the mechanisms determining them are not necessarily the same.…”

Section: Introductionmentioning

confidence: 99%

Eggshell Biliverdin and Protoporphyrin Pigments in a Songbird: Are They Derived from Erythrocytes, Blood Plasma, or the Shell Gland?

Hargitai

Boross

Hámori

et al. 2017

Physiological and Biochemical Zoology

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Biliverdin and protoporphyrin pigments are deposited into the eggshell when the developing egg is in the shell gland. However, the site of synthesis of eggshell pigments is still uncertain, although it may influence the possible costs and potential functions of eggshell coloration in avian species. Eggshell pigments may be derived from red blood cells or be produced in other organs and then transferred to the shell gland, or they may be synthesized de novo in the shell gland. We studied in the canary (Serinus canaria) whether eggshell blue-green and brown pigmentations are associated with experimentally elevated anemia, female hematocrit level, immature erythrocyte percentage, and feces and plasma pigment levels during egg laying to find out the possible origin of eggshell pigments. We found no significant effects of hematocrit level or experimentally elevated anemia on intensity of eggshell blue-green and brown pigmentations; therefore, we consider it less likely that eggshell pigments are derived from erythrocytes. In addition, we found no significant associations between female feces biliverdin concentration during egg laying and intensity of eggshell blue-green pigmentation, suggesting that eggshell biliverdin may not originate from the spleen or liver. We found a negative association between plasma and feces protoporphyrin concentrations during egg laying and eggshell brown chroma. This result suggests that an increased production of protoporphyrin in the liver, which could have elevated plasma and feces protoporphyrin concentrations, could inhibit eggshell protoporphyrin pigmentation, probably through affecting enzymatic activities. We suggest that both pigments are produced de novo in the shell gland in the canary, but circulating pigment levels may influence shell gland pigment synthesis, thus connecting the physiological status of the female to eggshell coloration.

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Comparison of HMOX1 expression and enzyme activity in blue-shelled chickens and brown-shelled chickens

Cited by 6 publications

References 21 publications

Recent advances in avian egg science: A review

Recent advances in avian egg science: A review

Eggshell color in brown-egg laying hens — a review

Eggshell Biliverdin and Protoporphyrin Pigments in a Songbird: Are They Derived from Erythrocytes, Blood Plasma, or the Shell Gland?

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