Genetic diversity of tyrosine hydroxylase (TH) and dopamine b-hydroxylase (DBH) genes in cattle breeds

Lourenco-Jaramillo, Diana Lelidett; Sifuentes‐Rincón, Ana María; Parra‐Bracamonte, Gaspar Manuel; Rosa-Reyna, Xochitl Fabiola De la; Segura‐Cabrera, Aldo; Arellano-Vera, Williams

doi:10.1590/s1415-47572012000300009

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…Significant DBH haplotype differences between Brahman cattle and the three B. t. taurus breeds, Charolais, Holstein, and Lidia, were found. The authors stated that detected polymorphism is interesting from a behavioural point of view because of the observed differences in temperament between these breeds (Lourenco-Jaramillo et al 2012).…”

Section: Discussionmentioning

confidence: 99%

The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs

et al. 2021

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The genetic basis of aggressive behaviour has been examined extensively, including analysis of genes encoding neurotransmitters, signalling molecules and regulatory enzymes, as well as their synthesis and degradation. Dopamine beta-hydroxylase, an enzyme catalysing the conversion of dopamine into norepinephrine in synaptic endings, significantly affects the modulation of emotional states and behaviour. The aim of this study was to determine the association of C789A polymorphism in the canine dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs. A total of 110 dogs of different breeds were analysed. All animals were classified according to their individual behavioural characteristics, defined by a veterinary interview and observation. Polymorphism was analysed using ACRS-PCR (amplification created restriction site-polymerase chain reaction) method. Significant differences in DBH genotypes and allele frequency between aggressive and non-aggressive dogs were observed (χ2 = 16,232, P = 0.0003). In aggressive dogs, the CC genotype (0.788) and C allele (0.815) were most frequent while in non-aggressive dogs, their frequencies were significantly lower (0.361 and 0.404, respectively). The obtained results indicate that DBH is a promising candidate gene for canine behavioural study.

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Section: Discussionmentioning

confidence: 99%

The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs

et al. 2021

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“…A theme of involvement in neural development and synaptic function is evident amongst the candidates. A notable absence from this list of candidates are SNP in genes encoding adrenergic receptors or enzymes tyrosine hydroxylase and dopamine-β-hydroxylase involved in the dopaminenorepinephrine-epinephrine synthesis pathway, which harbor known polymorphisms in cattle (Hu et al, 2010;Lourenco-Jaramillo et al, 2012). For a review of candidate genes associated with other behavioral traits in cattle see Friedrich et al (2015).…”

Section: Gwas Studies Of Fsmentioning

confidence: 99%

Adrenergic Tone as an Intermediary in the Temperament Syndrome Associated With Flight Speed in Beef Cattle

Colditz

2021

Front. Anim. Sci.

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The temperament of farm animals can influence their resilience to everyday variations within the managed production environment and has been under strong direct and indirect selection during the course of domestication. A prominent objective measure used for assessing temperament in beef cattle is the behavioral flight response to release from confinement in a crush or chute. This behavioral measure, termed flight speed (also known as escape velocity) is associated with physiological processes including body temperature, feeding behavior, growth rate, carcass composition, immune function, and health outcomes. This review examines the functional links between this suite of traits and adrenergic activity of the sympathetic nervous system and the adrenomedullary hormonal system. It is suggested that flight speed is the behavioral aspect of an underlying “flightiness” temperament syndrome, and that elevated adrenergic tone in animals with a high level of flightiness (i.e., flighty animals) tunes physiological activities toward a sustained “fight or flight” defense profile that reduces productivity and the capacity to flourish within the production environment. Nonetheless, despite a common influence of adrenergic tone on this suite of traits, variation in each trait is also influenced by other regulatory pathways and by the capacity of tissues to respond to a range of modulators in addition to adrenergic stimuli. It is suggested that tuning by adrenergic tone is an example of homeorhetic regulation that can help account for the persistent expression of behavioral and somatic traits associated with the flight speed temperament syndrome across the life of the animal. At a population level, temperament may modulate ecological fit within and across generations in the face of environmental variability and change. Associations of flight speed with the psychological affective state of the animal, and implications for welfare are also considered. The review will help advance understanding of the developmental biology and physiological regulation of temperament syndromes.

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“…At the molecular level, Lourenco-Jaramillo et al (2012), found significantly different haplotype distributions of single nucleotide polymorphisms (SNPs) located in two key enzymes (tyrosine hydroxylase and dopamine beta-hydroxylase) for dopamine and noradrenaline production. The authors proposed that these SNPs could be related to differences in temperament related to the genetic background of cattle (Lourenco-Jaramillo et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Bovine dopamine receptors DRD1, DRD4, and DRD5: genetic polymorphisms and diversities among ten cattle breeds

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to analyze the allelic frequency distribution and segregation among breeds and/or between different cattle genetic groups of four novel single nucleotide polymorphisms of the bovine DRD1 and DRD5 genes and one reported SNP from the DRD4 gene. One hundred and nine-animals from ten different cattle breeds were genotyped and allelic frequencies for each locus were estimated. There were significant differences in the allelic frequencies (P < 0.05) among breeds for the DRD1 and DRD5 markers. The allelic frequencies for markers DRD1-825A>G and DRD5-378C>T were also significantly different between groups differing in genetic background. Because differences in temperament have been reported between Bos taurus taurus and B. taurus indicus breeds and their crosses, further studies are needed to investigate if any association exists between described markers and cattle behavior traits.

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Genetic diversity of tyrosine hydroxylase (TH) and dopamine b-hydroxylase (DBH) genes in cattle breeds

Cited by 9 publications

References 31 publications

The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs

The association of C789A polymorphism in the dopamine beta-hydroxylase gene (DBH) and aggressive behaviour in dogs

Adrenergic Tone as an Intermediary in the Temperament Syndrome Associated With Flight Speed in Beef Cattle

Bovine dopamine receptors DRD1, DRD4, and DRD5: genetic polymorphisms and diversities among ten cattle breeds

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