Unusual intron in the second exon of a Type III polyketide synthase gene of Alpinia calcarata Rosc.

Radhakrishnan, E. K.; Varghese, Rintu; Soniya, E. V.

doi:10.1590/s1415-47572010000100024

Cited by 4 publications

(1 citation statement)

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“…[ 19 ] In a molecular study, genomic exploration of polyketide synthase (PKS) in A. calcarata identified the presence of an unusual intron at the region to form a second exon of typical PKSs. [ 20 ] It forms a gateway information of distribution of novel PKSs in Zingiberaceae. [ 20 ]…”

Section: Introductionmentioning

confidence: 99%

Alpinia calcarata Roscoe: A potential phytopharmacological source of natural medicine

Islam

2015

Phcog Rev

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Alpinia calcarata Roscoe (Family: Zingiberaceae), is a rhizomatous perennial herb, which is commonly used in the traditional medicinal systems in Sri Lanka. Alpinia calcarata is cultivated in tropical countries, including Sri Lanka, India, and Malaysia. Experimentally, rhizomes of Alpinia calcarata are shown to possess antibacterial, antifungal, anthelmintic, antinociceptive, anti-inflammatory, antioxidant, aphrodisiac, gastroprotective, and antidiabetic activities. Phytochemical screening revealed the presence of polyphenols, tannins, flavonoids, steroid glycosides and alkaloids in the extract and essential oil of this plant. Essential oil and extracts from this plant have been found to possess wide range of pharmacological and biological activities. This article provides a comprehensive review of its ethnomedical uses, chemical constituents and the pharmacological profile as a medicinal plant. Particular attention has been given to the pharmacological effects of the essential oil of Alpinia calcarata in this review so that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.

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Section: Introductionmentioning

confidence: 99%

Alpinia calcarata Roscoe: A potential phytopharmacological source of natural medicine

Islam

2015

Phcog Rev

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Chalcone synthases (CHSs): the symbolic type III polyketide synthases

Pandith

Ramazan

Khan

et al. 2019

Planta

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Type III polyketide synthase repertoire in Zingiberaceae: computational insights into the sequence, structure and evolution

et al. 2016

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Zingiberaceae or 'ginger family' is the largest family in the order 'Zingiberales' with more than 1300 species in 52 genera, which are mostly distributed throughout Asia, tropical Africa and the native regions of America with their maximum diversity in Southeast Asia. Many of the members are important spice, medicinal or ornamental plants including ginger, turmeric, cardamom and kaempferia. These plants are distinguished for the highly valuable metabolic products, which are synthesised through phenylpropanoid pathway, where type III polyketide synthase is the key enzyme. In our present study, we used sequence, structural and evolutionary approaches to scrutinise the type III polyketide synthase (PKS) repertoire encoded in the Zingiberaceae family. Highly conserved amino acid residues in the sequence alignment and phylogram suggested strong relationships between the type III PKS members of Zingiberaceae. Sequence and structural level investigation of type III PKSs showed a small number of variations in the substrate binding pocket, leading to functional divergence among these PKS members. Molecular evolutionary studies indicate that type III PKSs within Zingiberaceae evolved under strong purifying selection pressure, and positive selections were rarely detected in the family. Structural modelling and protein-small molecule interaction studies on Zingiber officinale PKS 'a representative from Zingiberaceae' suggested that the protein is comparatively stable without much disorder and exhibited wide substrate acceptance.

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Unusual intron in the second exon of a Type III polyketide synthase gene of Alpinia calcarata Rosc.

Cited by 4 publications

References 20 publications

Alpinia calcarata Roscoe: A potential phytopharmacological source of natural medicine

Alpinia calcarata Roscoe: A potential phytopharmacological source of natural medicine

Chalcone synthases (CHSs): the symbolic type III polyketide synthases

Type III polyketide synthase repertoire in Zingiberaceae: computational insights into the sequence, structure and evolution

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