Myeloperoxidase gene-463G &gt; a polymorphism and premature coronary artery disease

Chen, Zhong; Yin, Qin; Ma, Genshan; Zhang, Hua; Zheng, Rong; Wang, Jiahong; Gao, Chun-heng

doi:10.1590/s1415-47572009005000035

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…Work produced by Tang et al [34] in 2013 also included studies that were not at HWE. [21,22] In addition, the individual study by Du et al [35] was carried out by the similar author group to the study by Wu et al [36] Hence, their results were not as accurate as that from the current meta-analysis.…”

Section: Discussionmentioning

confidence: 77%

“…They found that the A allele of MPO -463G/A gene polymorphism is associated with decreased risk of CAD except in the Europeans. Deviation of these studies, which were also used in the works of Yin et al, [20] Li et al, [21] and Chen et al, [22] limits their objectivity. Work produced by Tang et al [34] in 2013 also included studies that were not at HWE.…”

Section: Discussionmentioning

confidence: 99%

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PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease

Wang

Qian

et al. 2017

Medicine

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Background:Myeloperoxidase (MPO) -463G/A gene polymorphism may be associated with an increased risk of developing coronary artery disease (CAD). Studies on the subject, however, do not provide a clear consensus. This meta-analysis was performed to explore the relationship between MPO gene -463G/A polymorphism and CAD risk.Methods:This meta-analysis combines data from 4744 subjects from 9 independent studies. By using fixed or random effect models, the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed.Results:Our analysis found a significant association between MPO gene -463G/A polymorphism and CAD in the whole population under all genetic models: allelic (OR: 0.68, 95% CI: 0.54–0.85, P = 0.0009), recessive (OR: 0.41, 95% CI: 0.22–0.76, P = 0.005), dominant (OR: 0.682, 95% CI: 0.534–0.871, P = 0.002), homozygous (OR: 0.36, 95% CI: 0.16–0.79, P = 0.01), heterozygous genetic model (OR: 0.832, 95% CI: 0.733–0.945, P = 0.004), and additive (OR: 0.64, 95% CI: 0.46–0.90, P = 0.01), especially in the Chinese subgroup (P < 0.05). On the contrary, we found no such relationship in the non-Chinese subgroup (P > 0.05).Conclusion:The MPO gene -463G/A polymorphism is associated with CAD risk, especially within the Chinese population. The A allele of MPO gene -463G/A polymorphism might protect the people from suffering the CAD risk.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease

Wang

Qian

et al. 2017

Medicine

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“…Two SNPs in the MPO gene, that is, MPO 129G/A and MPO 463G/A, were considered. Five studies [ 10 , 15 – 18 ] including 1881 cases and 5554 controls investigated the association between the MPO 463G/A genotype and the CAD risk. Three studies [ 16 , 19 , 20 ] comprising 1610 patients and 1739 controls addressed the association between the MPO 129G/A polymorphism and CAD and were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…[ 9 ] The A-allele at the MPO gene position 129 and homozygosity for a G at position 463 result in lower MPO concentrations. [ 10 , 11 ] Therefore, we performed a comprehensive meta-analysis with the aim of determining whether there are significant associations of the MPO 463G/A and 129G/A polymorphisms with the susceptibility to CAD.…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase polymorphism and coronary artery disease risk

Wang¹,

Chen²,

Wang³

et al. 2017

Medicine

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The myeloperoxidase (MPO) gene 463G/A and 129G/A polymorphisms have been reported to be associated with coronary artery disease (CAD), but the results remain inconclusive. This meta-analysis was designed to clarify these controversies.PubMed, EMBASE, and the Cochrane Library were used to retrieve the relevant literature up to March 2015 according to keywords. A total of 8 case–control studies, including 3491 cases and 7293 controls, were included in this meta-analysis. Summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated.There was strong evidence of an association between the MPO 463G/A polymorphism and CAD. The data revealed that only the dominant model was associated with CAD (dominant model: OR = 0.872, 95% CI = 0.77–0.99). Regarding the 129G/A gene polymorphism, the pooled OR for the genotype AA + AG versus GG was 0.906 (95% CI = 0.74–1.10).This meta-analysis suggested an association between the MPO 463G/A polymorphism and the risk of CAD, but there is no significant association between the MPO 129G/A gene polymorphism and CAD risk.

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“…With the rapid development of molecular biology technology, scientists have found many gene polymorphisms closely related to coronary heart disease susceptibility, such as those of angiotensin converting enzyme (Cambien et al, 1992;Narne et al, 2012), apolipoprotein (Hsu et al, 2006;Jang et al, 2009;Huang et al, 2012), cell factor (Zhong et al, 2009;Fragoso et al, 2010;Jin et al, 2012;Srikanth Babu et al, 2012), coagulation system (Pegoraro, 2005;Friso et al, 2012), and endothelin (Popov et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population

Bao

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We investigated genetic susceptibility to coronary artery disease (CAD) by studying the association of MKL1 gene polymorphisms with CAD in the Chinese Han population. We performed a case-control study with 476 unrelated CAD patients and 325 non-CAD controls. All SNPs were genotyped with a TaqMan SNP genotyping assay. The distribution of MKL1-184C>T gene polymorphism in each group was in Hardy-Weinberg equilibrium. The frequency of the MKL1 T allele in the CAD group was significantly higher than in the control group (38.6 vs 30.8%). After logistic regression models adjusted for CAD risk factors, the risk of CAD among CT genotypes was 1.765 times higher than among the CC genotypes [odds ration (OR) = 1.765, 95% confidence interval (CI) = 1.246-2.5], and for TT genotypes it was 1.806 times higher than for the CC genotypes (OR = 1.806, 95%CI = 1.203-2.71). In summary, genotypes with at least one T allele (CT or TT genotypes) had a significantly increased CAD risk than the CC genotypes, with a ratio of 1.78 to 1 (OR = 1.780, 95%CI = 1.311-2.418). There was a close association between -184 T allele and 3VD (OR = 1.614, 95%CI = 1.259-2.07, P < 0.05). We conclude that the -184C>T of MKL1 is an important susceptibility factor for CAD in the Han Chinese in Henan Province. Homozygosity for the T allele is not only associated with an increased risk for CAD, it is also correlated with severity of stenosis in the Chinese Han population.

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Myeloperoxidase gene-463G > a polymorphism and premature coronary artery disease

Cited by 12 publications

References 17 publications

PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease

PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease

Myeloperoxidase polymorphism and coronary artery disease risk

MKL1-184C>T gene polymorphism is associated with coronary artery disease in the Chinese Han population

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