Association of the bovine major histocompatibility complex (BoLA) BoLA-DRB3 gene with fat and protein production and somatic cell score in Brazilian Gyr dairy cattle (Bos indicus)

Abstract

The effect of the bovine major histocompatibility complex (BoLA) locus on animal health may be due to a direct action of its alleles on immune functions, whereas its indirect effect on production traits might be explained by the better general health conditions of more productive animals. In the present study, the BoLA-DRB3 gene was investigated in 1058 cows belonging to seven Brazilian Gyr Dairy herds (Bos indicus, Zebu cattle). A total of 37 alleles were identified, 15 of them described for the first time in a Zebu breed. A highly significant association (p < 0.02) was observed between allele *54 and a decrease (-26.1 kg) in milk protein yield and there was a significant association (p < 0.05) between this allele and lower (-26.07 kg) milk fat yield. There was also a significant association (p < 0.05) between allele *6 and decreased (-12.47 kg) milk protein and allele *7 and increased (12.72 kg) milk protein. There were also indications of association (p < 0.10) between somatic cell score (SCS) and alleles *3 (SCS increased by 0.54 units) and *31 (SCS increased by 0.46 units). The highly significant association of allele *54 with lower protein yield suggests the possible use of this allele in marker-assisted selection programs

Asociación del locus BOLA-DRB3.2 con el virus de la leucosis bovina en el ganado criollo colombiano

“…El número de alelos y sus frecuencias son similares a los reportados en otros ganados criollos (FERNÁNDEZ et al, 2008;GIOVAMBATTISTA et al, 1996;KELLY et al, 2003;RIPOLI et al, 2004) y en razas foráneas presentes en América (JULIARENA et al, 2008;MARTÍNEZ et al, 2005;NASCIMENTO et al, 2006;PANEI et al, 2009;ZAMBRANO et al, 2009b). Otros estadísticos relacionados con la diversidad genética del locus BoLA-DRB3.2* en estas mismas muestras se presentan en artículo previo (HERNÁNDEZ et al, 2013).…”

“…Se han identificados 14 genes en esta región: DRA, DRB (DRB1, DRB2, DRB3), DQA (DQA1, DQA2, DQA3, DQA4, DQA5) y DQB (DQB1, DQB2, DQB3, DQB4, DQB5) (TAKESHIMA y AIDA, 2006), donde el gen DRB3 es el más estudiado, este tiene una longitud de 11,4 Kbp con cinco intrones y seis exones, de los cuales el más polimórfico es el exón dos (BoLA-DRB3.2) de un tamaño aproximado de 270 bp (RUSSELL et al, 2004). El gen DRB3.2 ha sido asociado con caracteres productivos (NASCIMENTO et al, 2006;ZAMBRANO et al, 2009a) y con enfermedades (GÓMEZ et al, 2006;JULIARENA et al, 2008;PANEI et al, 2009).…”

Cluster of differentiation 14 gene polymorphism and its association with incidence of clinical mastitis in Karan fries cattle

“…Candidate genes such as BoLA-DRB3 [11,12], FEZ [13], TLR4 [14,15], CARD 15 [16,17], cluster of differentiation 14 (CD14) [18][19][20] and many more genes are associated with mastitis resistance/susceptibility in different cattle breeds. CD14 gene is one of the excellent candidates for mastitis resistance in cattle and has been mapped on BTA 7 [21].…”

Association of gene BoLA DRB3.2 with production traits in a dairy herd of Antioquia, Colombia

“…Their elevated level of expression and high polymorphism makes them potential molecular markers for Molecular Marker-assisted selection procedures (MAS). More than 100 different alleles (8,9) have been identified from exon 2, and some of them have been associated to the occurrence of infectious diseases and milk, fat and protein production (6,(10)(11)(12)(13).…”