Cytogenetic study of Brazilian patients with myelodysplastic syndrome (MDS)

Abstract

Bone marrow cytogenetic studies were performed on 93 patients with primary myelodysplastic syndrome (MDS) diagnosed at the Clinical Hospital of the Federal University of Paraná, Brazil. Chromosomal alterations were observed in 69% of the patients. Monosomy of chromosome 7, deletions of 7q, 5q, 12p and 20q, rearrangements of 11q23 and trisomies of chromosomes 8 and 21 were the most frequent abnormalities observed. Among adult patients the most frequent aberrations were rearrangements of 11q23 and 12p deletions. In the pediatric group, 5q deletions and monosomy of chromosome 7 were the most common alterations.

First Cytogenetic Profile of Omani Patients with de novo Myelodysplastic Syndromes: Comparison with data from Asia, Africa, Europe and North and South America

“…22 Brazilian patients had the youngest median age (29 years old). 27 Among Omani patients, the male-to-female ratio was 1:1, which was in accordance with a sample from Thailand and close to ratios reported from Brazil (1.2:1) and Germany (1.3:1); 3,26,27 however, this finding was contrary to many other Asian countries and certain European, North American and African countries in which males outnumbered females. 7,11,13,15,22,28,30,31 Further research is needed to determine a possible cause for this gender difference between populations.…”

“…Studies from Germany, Japan and Argentina also reported patients with loss of the Y chromosome (7.0%, 1.1% and 2.7%, respectively); 3,15,29 however, this abnormality was not observed among patients from Thailand, Switzerland or Brazil. 7,26,27 Similarly, trisomy 21 was not observed Patients with abnormal karyotypes, n (%) G m id è n e e t a l. Le e et al . 31 (1 99 9)…”

“…3,7,11,13,15,16,22,[26][27][28][29][30][31][32][33] The median age of patients with MDS in Oman (65 years old) was lower than that reported from Europe (65-74 years old) but was higher compared to other Asian countries (50-60 years old). 10,13,15,17,[19][20][21][22]26,28,31 The median age of the patients in Tunisia was 60 years old.…”

“…31 The overall percentage of abnormal karyotypes was lower among Omanis compared to other populations (22.2% versus 23.9-68.8%), although this may be due to the low number of patients included in the Omani sample. 3,7,11,13,15,16,22,[26][27][28][29][30][31][32][33] The highest percentage of patients with abnormal karyotypes was reported from Brazil. 27 The frequency of cytogenetic abnormalities according to MDS subtype was found to be different among Omani patients when compared to other populations, with most Omani patients having normal karyotypes and thus a good prognosis.…”

“…3,7,11,13,15,16,22,[26][27][28][29][30][31][32][33] The highest percentage of patients with abnormal karyotypes was reported from Brazil. 27 The frequency of cytogenetic abnormalities according to MDS subtype was found to be different among Omani patients when compared to other populations, with most Omani patients having normal karyotypes and thus a good prognosis. 3,7,11,13,15,16,22,[26][27][28][29][30][31][32][33] The current research sought to compare the cytogenetic characteristics of Omani patients with MDS to those reported among other geographic/ ethnic populations.…”