Genetic characterization of the population of São Luís, MA, Brazil

Ferreira, Francileide Lisboa; Leal-Mesquita, E R; Santos, Sidney Emanuel Batista dos; Ribeiro-dos-Santos, Ândrea

doi:10.1590/s1415-47572005000100004

Cited by 8 publications

(5 citation statements)

References 46 publications

(48 reference statements)

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“…The high contribution of Africans to the gene pool of our African descent sample of Jequié differs from that seen in previous studies of northeastern Brazilian populations (Callegari-Jacques et al 2003; Ferreira et al 2005), possibly due to the careful choice of African-descendants by the morphological ethnic classification (Azevêdo, 1980) used in our study.…”

Section: Resultscontrasting

confidence: 98%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

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The African descent population of the Bananal community in the Brazilian state of Bahia (BA) was characterized as a genetic isolate and analyzed for some short tandem repeat (STR) microsatellite autosomic polymorphic loci (CSF1PO, TH01, TPOX, F13A1, FESFPS and vWA). These genetic variants were further compared to data obtained from an urban sample from the town of Jequié (BA) regarding demographic and anthropogenetic aspects. The Bananal sample comprised 32 unrelated individuals whereas Jequié was represented by 76 individuals. The Bananal Negroid Phenotypic Index (NPI) was 0.98 and the Negroid Cultural Index (NCI) 0.24. Consanguineous marriages occurred at a frequency of 34.61% and the F value was 0.0126. All six loci studied were in Hardy-Weinberg Equilibrium (p > 0.05). The genotypic and allele frequencies of the CSF1PO and vWA loci were similar. In the Bananal population the genic diversity of the THO1 locus was 66.8% and that of the F13A1 locus was 83.7%. The estimated ethnic racial admixture was 81% African and 19% Amerindian. The multiple correlation coefficient (R 2 ) indicated adequate adaptation (99%). Total genetic variation for the six loci was 82.9% with an index of 6.7% for population subdivision (G ST ' = 0.067). Anthropologic data and results obtained from the allele frequencies of the loci studied are indicative of a genetic isolate in Bananal, reminiscent of the a`quilombo community' (i.e. one founded by run away slaves).

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Section: Resultscontrasting

confidence: 98%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

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“…The population from the state of Maranhão, located in the Northeast region of Brazil, is also composed by the miscegenation between European, African, and Native American populations 10 , 25 . This fact was noted in our study through the analysis of genomic ancestry.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have been conducted in Brazil in order to determine the population's autosomal ancestry and its regional differences 10 – 12 , 17 , 24 , 25 ; and also the ancestry of the paternal lineage through Y-STR (Y- chromosomal Short Tandem Repeats) and Y-SNP (Y- chromosomal Single Nucleotide Polymorphism) markers; however, there is little information regarding the population of Maranhão 26 – 29 . Our study aimed to analyze the pattern of autosomal and Y chromosome ancestry in the general population and in patients with T1D in the state of Maranhão and to evaluate these findings with the genetic profile of HLA class II in these patients.…”

Section: Introductionmentioning

confidence: 99%

Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population

Azulay

Porto

Silva

et al. 2021

Sci Rep

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This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB1*03 and DRB1*04 alleles presented risk association with T1D. When the Y chromosome was European, DRB1*03 and DRB1*04 homozygote and DRB1*03/DRB1*04 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB1*03 and DRB1*04 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.

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“…Além disso, não foram investigados outros genes que estão envolvidos na fisiopatogênese do AER, como o HLA-G, que é reconhecidamente um fator imunológico protetor para evitar reação aloimune mãe-feto 24,25 . Um estudo de caracterização genética da população de São Luís, Maranhão, mostrou uma diversidade genética, com influência de povos ameríndios, africanos e europeus, caracterizando uma região altamente miscigenada 26 .…”

Section: Discussionunclassified

Associação de alelos HLA e aborto espontâneo recorrente em uma população de São Luís/Maranhão, na região Nordeste do Brasil

Silva¹,

Mesquita²,

Patrício³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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Genetic characterization of the population of São Luís, MA, Brazil

Cited by 8 publications

References 46 publications

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population

Associação de alelos HLA e aborto espontâneo recorrente em uma população de São Luís/Maranhão, na região Nordeste do Brasil

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