Apolipoprotein E polymorphism as a predictor for cognitive decline and dementia in the Saudi general population over 65 years

Abstract

Specific Apolipoprotein E (ApoE) genotypes are thought to be associated with risk for Alzheimer's disease (AD). It is essential to understand how this genetic factor affects cognitive decline and dementia in the general population. One hundred and fifty elderly persons residing at social nursing centers in different provinces of Saudi Arabia were tested for ApoE genotypes, using PCR amplification of genomic DNA followed by DNA digestion with Cfo I. All subjects were diagnosed with regard to cognitive decline and dementia. In the general Saudi population, the ApoE4 allele was found to be a weaker predictor for dementia than for AD. This may be a result of non-AD pathological processes and/or of most prevalent dementia at an age when the ApoE4 effect on the AD/dementia risk has decreased.

Analysis of the APO B R3500Q Mutation and APOE Polymorphism in Taif Saudi Population using Polymerase Chain Reaction- Reveres Hybridization Technique

“…Among the resulted five genotypes E3/E3 was the most prevalent genotype ( 63%) and the lowest was E2lE4 (1%) while the prevalence of E3/E4, E2/E3 and E4/E4 genotypes were 25%,8.5% and 2.5% respectively. These genotypes prevalence's are concordant with the results among different population such as Nigerians (44); African Americans [45]; American Indian [46]; Caucasians [47]; Germany [48]; Finland [49]; France [50]; Italy [51]; Chinese [52]; Japanese [53] and Swedish [18]. In comparison with previously published Saudi studies, there are three published studies demonstrate apoE genotypes prevalence and allele frequencies with general population over 65 years [54]; with normal individuals [55] and with primary glaucoma Saudi patients [19].…”

Assessment of Possible Association Between Antioxidant Levels and Apoe Gene Polymorphism in Demented Saudi Population

“…The differences in the prevalence of E3/E3 and E3/E4 in persons with and without dementia were nonsignificant (p= 0.2015). Other genotypes with an E2 allele were absent in the tested population (Al-Khedhairy, 2004). …”