2003
DOI: 10.1590/s1415-47572003000200001
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Chromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridization

Abstract: We applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies d… Show more

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Cited by 2 publications
(5 citation statements)
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“…Experimentos de CGH metafásica tem demonstrado que podem ser detectáveis, através de limiares diagnósticos fixos, deleções de copia simples que se encontram na faixa de 10-20 Mb (KALLIONIEMI et al, 1994;BENTZ et al, 1998). Kirchhoff et al (1998) KIRCHHOFF et al, 1998KIRCHHOFF et al, , 1999 (TARKKANEN et al, 1995;FORUS et al, 1995b;TARKKANEN et al, 1999;STOCK et al, 2000;ZIELENSKA et al, 2001;OZAKI et al, 2002;BATANIAN et al, 2002;BARUFFI et al, 2003;OVERHOLTZER et al, 2003;LAU et al, 2004;OHATA et al, 2006;AGUIAR et al, 2007).…”
Section: Fatores Prognósticos E Tratamentounclassified
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“…Experimentos de CGH metafásica tem demonstrado que podem ser detectáveis, através de limiares diagnósticos fixos, deleções de copia simples que se encontram na faixa de 10-20 Mb (KALLIONIEMI et al, 1994;BENTZ et al, 1998). Kirchhoff et al (1998) KIRCHHOFF et al, 1998KIRCHHOFF et al, , 1999 (TARKKANEN et al, 1995;FORUS et al, 1995b;TARKKANEN et al, 1999;STOCK et al, 2000;ZIELENSKA et al, 2001;OZAKI et al, 2002;BATANIAN et al, 2002;BARUFFI et al, 2003;OVERHOLTZER et al, 2003;LAU et al, 2004;OHATA et al, 2006;AGUIAR et al, 2007).…”
Section: Fatores Prognósticos E Tratamentounclassified
“…Paciente B 1,2q,3q,5q,9q,10q,15q,18q,21q. Paciente C 1p,2,3,5,6,7,9p,10p,11q,12q,15q,16q,18q,19,20q,21q,Xp TARKKANEN et al, 1999;OZAKI et al, 2002;BARUFFI et al, 2003 FORUS et al, 1995b;STOCK et al, 2000;ZIELENSKA et al, 2001;OZAKI et al, 2002;BATANIAN et al, 2002;BARUFFI et al, 2003;OVERHOLTZER et al, 2003;LAU et al, 2004;OHATA et al, 2006;AGUIAR et al, 2007) (KIRCHHOFF et al, 1998).…”
Section: Cromossomos Ou Regiões Cromossômicas Com Alterações Não Compunclassified
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