The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

Corvelo, Tereza Cristina de Oliveira; Aguiar, Délia Cristina Figueira; Sagica, Fernanda do Espírito Santo

doi:10.1590/s1415-47572002000300001

Cited by 12 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the 25% Lewis negative (Le aÀbÀ ) individuals observed in this study is significantly higher than the 5.7% observed in Scandinavia or the 10% observed in Portugal and Spain [Torrado et al, 1997;Serpa et al, 2003;Larsson et al, 2006]. However, the frequency of Lewis-negative individuals in Nicaragua is similar to Colombia (22%) [Torrado et al, 1997] and can reach up to 40% in isolated black communities in Brazil [Corvelo et al, 2002].…”

Section: Discussionmentioning

confidence: 46%

Genetic susceptibility to symptomatic norovirus infection in Nicaragua

Bucardo

Kindberg

Paniagua

et al. 2009

Journal of Medical Virology

View full text Add to dashboard Cite

Host genetic resistance to Norovirus (NoV) has been observed in challenge and outbreak studies in populations from Europe, Asia, and USA. In this study, we have investigated if histo-blood group antigens can predict susceptibility to diarrhea caused by NoV in Nicaragua, Central America, and if this can be reflected in antibody-prevalence and titer to NoV among individuals with different histo-blood group antigen phenotypes. Investigation of 28 individuals infected with NoV and 131 population controls revealed 6% of non-secretors in the population and nil non-secretors among patients infected with NoV, suggesting that non-secretors may be protected against NoV disease in Nicaragua. Surprisingly, 25% of the population was Lewis negative (Le(a-b-)). NoV infections with genogroup I (GI) and GII occurred irrespective of Lewis genotype, but none of the Lewis a positive (Le(a + b-)) were infected. The globally dominating GII.4 virus infected individuals of all blood groups except AB (n = 5), while the GI viruses (n = 4) infected only blood type O individuals. Furthermore, O blood types were susceptible to infections with GI.4, GII.4, GII.7, GII.17, and GII.18-Nica viruses, suggesting that secretors with blood type O are susceptible (OR = 1.52) and non-secretors resistant. The overall antibody-prevalence to NoV GII.3 VLP was 62% with the highest prevalence among blood type B carriers (70%) followed by A (68%) and O (62%). All four investigated individuals carrying blood type AB were antibody-negative. Among secretors, 63% were antibody-positive compared to 33% among non-secretors (P = 0.151). This study extends previous knowledge about the histo-blood group antigens role in NoV disease in a population with different genetic background than North American and European.

show abstract

Section: Discussionmentioning

confidence: 46%

Genetic susceptibility to symptomatic norovirus infection in Nicaragua

Bucardo

Kindberg

Paniagua

et al. 2009

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…P[6] strains that have been most frequently found in individuals of the Lewis negative phenotype are seldom encountered in Europe where this phenotype represents only 5–10% of the population. Interestingly, its frequency can be as high as 30% in some Latino-American and African populations 42 , 43 where those strains are more common. Since mucins from Lewis positive individuals also contain the un-substituted type 1 precursor, albeit in lower amount than Lewis negative individuals 44 , Lewis positive children may also be infected, although less frequently, increasing to some extent the pool of susceptible individuals in the population.…”

Section: Discussionmentioning

confidence: 99%

Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection

Barbé

Moullac-Vaidye

Echasserieau

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Human strains of rotavirus A (RVAs) recognize fucosylated glycans belonging to histo-blood group antigens (HBGAs) through their spike protein VP8*. Lack of these ligands due to genetic polymorphisms is associated with resistance to gastroenteritis caused by P[8] genotype RVAs. With the aim to delineate the contribution of HBGAs in the process, we analyzed the glycan specificity of VP8* proteins from various P genotypes. Binding to saliva of VP8* from P[8] and P[4] genotypes required expression of both FUT2 and FUT3 enzymes, whilst binding of VP8* from the P[14] genotype required FUT2 and A enzymes. We further defined a glycan motif, GlcNAcβ3Galβ4GlcNAc, recognized by P[6] clinical strains. Conversion into Lewis antigens by the FUT3 enzyme impaired recognition, explaining their lower binding to saliva of Lewis positive phenotype. In addition, the presence of neutralizing antibodies was associated with the presence of the FUT2 wild type allele in sera from young healthy adults. Nonetheless, in vitro infection of transformed cell lines was independent of HBGAs expression, indicating that HBGAs are not human RV receptors. The match between results from saliva-based binding assays and the epidemiological data indicates that the polymorphism of human HBGAs controls susceptibility to RVAs, although the exact mechanism remains unclear.

show abstract

“…She also attributed this high frequency of Lewis (a-b-) phenotype due to decreased concentration of circulating Lewis antigen occurring during diseases caused by parasites, infection or other pathologic conditions. 16 The limitations of the study was the relatively low sample size which cannot be used as an assessment of prevalence of secretor status in the local population.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of secretor status and co-expression of lewis antigen in voluntary blood donors

Bharath

Arumugam

2016

Asian J Med Sci

View full text Add to dashboard Cite

Background: Blood group substances are present in soluble form in a majority of individuals in secretion such as saliva and body fl uids. Secretor status refers to the presence (SeSe and Sese) or absence (sese) of secretor gene which secrete ABH soluble substances. Secretor status can be used to resolve ABO discrepancies of people whose blood group cannot be identified by routine blood grouping and it can also help in identifying patients who may be a high risk group for getting certain diseases. Aims and Objectives:Our aim and objectives of the study is to fi nd out the Prevalence of Secretor Status and Co-expression of Lewis Antigens among the Voluntary Blood Donors.Materials and Methods:This study was conducted in sixty volunteers and the method used to determine the secretor status was hemagglutination inhibition method. Their blood was used to detect the type of Lewis (Le) antigen since the type of Lewis antigen correlated with the secretor status of the individual.Results:Among the sixty subjects tested, forty fi ve of them were found to be secretors and fifteen of them were Non-secretors. The number of Lewis (a+b-) individuals were twelve, Lewis (a-b+) were thirty nine and Lewis (a-b-) were nine.Conclusion:The prevalence of secretors was 75% and non-secretors were 25% respectively. We found 65 % of the volunteers were found to be Le (a-b+) positive, 20% were Le (a+b-) and the remaining 15% were Le (a-b-) which correlated with the ABH antigen secretor status.Asian Journal of Medical Sciences Vol.7(5) 2016 93-96

show abstract

The expression of ABH and Lewis antigens in Brazilian semi-isolated Black communities

Cited by 12 publications

References 24 publications

Genetic susceptibility to symptomatic norovirus infection in Nicaragua

Genetic susceptibility to symptomatic norovirus infection in Nicaragua

Histo-blood group antigen-binding specificities of human rotaviruses are associated with gastroenteritis but not with in vitro infection

The prevalence of secretor status and co-expression of lewis antigen in voluntary blood donors

Contact Info

Product

Resources

About