Partial duplication of chromosome 20(pter-&gt;q12)

Della-Rosa, Valter Augusto; Vianna‐Morgante, Angela Maria

doi:10.1590/s1415-47572000000300008

Genet. Mol. Biol.

2000

DOI: 10.1590/s1415-47572000000300008

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Partial duplication of chromosome 20(pter->q12)

Valter Augusto Della-Rosa

Angela Maria Vianna‐Morgante

Abstract: Partial duplication of chromosome 20 (20pter->20q12) resulting from a maternally inherited translocation t(14;20)(q11;q13) is described in a female child with neuropsychomotor retardation and multiple congenital anomalies. To our knowledge this is the largest duplication of chromosome 20 that includes segments of both the short and the long arms thus far described in a live-born child.

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2024

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Short report: Twins with 20p13 duplication. Case report and comprehensive literature review

Kennedy,

Savage,

Kaler

2024

Molec Gen & Gen Med

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BackgroundTrisomy 20p is a rare genetic condition caused by a duplication of the short arm of chromosome 20.MethodsWe employed clinical observation and molecular genetic testing (SNP microarray), to study identical twin males with an unknown dysmorphic syndrome. We conducted a literature review of trisomy 20p and collated the clinical and molecular genetic findings on 20 affected subjects reported since 2000.ResultsIdentical twin males, whose prenatal course was complicated by a twin‐to‐twin transfusion, manifested profound language and neurocognitive delays as well as distinctive facial dysmorphisms when evaluated at 2 years of age. SNP microarray identified identical duplications of 20p13 with no other chromosomal aberrations. A literature survey of 20p trisomy syndrome identified 20 other examples of this condition reported since 2000, which we collated with 33 summarized by Sidwell et al. (2000). Within the combined total of 55 affected individuals, we found a distinctive clinical phenotype that provides insight on the effects of abnormal dosage of genes in 20p13. These loci include FAM110A (OMIM 611393), ANGPT4 (OMIM 603705), RSPO4 (OMIM 610573), PSMF1 (OMIM 617858), SNPH (OMIM 604942), SDCBP2 (OMIM 617358), FKBP1A (OMIM 186945), TMEM74B, C20orf202, and RAD21L1 (OMIM 619533). Gene profiling highlighted that syntaphilin (SNPH) is highly expressed in mammalian brain, where it is considered critical for mitochondrial transport in neuronal axons, and to directly influence axonal morphogenesis and function.ConclusionWe propose that abnormal activity of syntaphilin engendered by the trisomy is primarily responsible for the language, neurocognitive, and gross motor delays reported in individuals with 20p trisomy. Additional studies, for example, characterization of cerebral organoids generated from affected patients may help to better understand this condition, and potentially suggest rational remedies to improve the lives of affected individuals and their families.

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Short report: Twins with 20p13 duplication. Case report and comprehensive literature review

Kennedy,

Savage,

Kaler

2024

Molec Gen & Gen Med

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Partial duplication of chromosome 20(pter->q12)

Cited by 1 publication

References 10 publications

Short report: Twins with 20p13 duplication. Case report and comprehensive literature review

Short report: Twins with 20p13 duplication. Case report and comprehensive literature review

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