Genetic effect on apgar score

Franchi-Pinto, Carla; Colletto, Glória Maria Duccini Dal; Krieger, Henrique; Beiguelman, B

doi:10.1590/s1415-47571999000100003

Cited by 5 publications

(9 citation statements)

References 8 publications

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“…The second twin is at greater risk of lower scores, which can be due to longer delivery time, risk of hypoxia, nondefinable fetal presentation before birth to decide the better tactics or complications during delivery. The proportion of low Apgar score in first-and second born reported by Franchi-Pinto et al (1999) corresponds with our findings. Fetal presentation at birth showed opposite effects in first-and second-born twins and should be further investigated, together with mode of delivery and in application of horizontal/nonhorizontal classification of presentation.…”

Section: Discussionsupporting

confidence: 92%

“…Our findings on birth order agree with previous findings. The first twin is in better clinical condition (Franchi-Pinto et al, 1999;Haest et al, 2005;Herbst & Kallen, 2008;Kwon et al, 2011;Morley et al, 1989;Thorngren-Jerneck & Herbst, 2001;Usta et al, 2002;Wen et al, 2004). The second twin is at greater risk of lower scores, which can be due to longer delivery time, risk of hypoxia, nondefinable fetal presentation before birth to decide the better tactics or complications during delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Replication studies of differences among first-and secondborn twins (Haest et al, 2005;Herbst & Kallen, 2008;Morley et al, 1989;Wen et al, 2004), among twins and singletons (Hegyi et al, 1998;Thorngren-Jerneck & Herbst, 2001), among term and preterm newborns (Dolgun et al, 2016;Morley et al, 1989) and among different presentation and modes of delivery (Rossi et al, 2011) followed this initial work. Two small studies (Franchi-Pinto et al, 1999;Riese, 1990) suggested that genetic factors also contribute to variation in Apgar scores. However, because of small sample sizes, the results of these studies were inconclusive.…”

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confidence: 99%

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Pre- and Perinatal Characteristics Associated with Apgar Scores in a Review and in a New Study of Dutch Twins

et al. 2019

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A literature review was carried out to identify pre and perinatal characteristics associated with variation in Apgar scores in population-based studies. The parameters identified in the literature search were included in the classical twin design study to estimate effects of pre and perinatal factors shared and nonshared by twins and to test for a contribution of genetic factors in 1- and 5-min Apgar scores in a large sample of Dutch monozygotic (MZ) and dizygotic (DZ) twins. The sample included MZ and DZ twins (N = 5181 pairs) recruited by the Netherlands Twin Register shortly after birth, with data on prenatal characteristics and Apgar scores at first and/or fifth minutes. The ordinal regression and structural equation modeling were used to analyze the effects of characteristics identified in the literature review and to estimate genetic and nongenetic variance components. The literature review identified 63 papers. Consistent with the review, we observed statistically significant effects of birth order, zygosity and gestational age (GA) for 1- and 5-min Apgar scores of both twins. Apgar scores are higher in first-born versus second-born twins and DZ first-born versus MZ first-born twins. Birth weight had an effect on the 5-min Apgar of the first born. Fetal presentation and mode of delivery had different effects on Apgar scores of first- and second-born twins. Parental characteristics and chorionicity did not have significant main effects on Apgar scores. The MZ twins’ Apgar correlations equaled the DZ Apgar correlations. Our analyses suggest that individual differences in 1- and 5-min Apgar scores are attributable to shared and nonshared pre and perinatal factors, but not to genotypic factors of the newborns. The main predictors of Apgar scores are birth order, zygosity, GA, birth weight, mode of delivery and fetal presentation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Pre- and Perinatal Characteristics Associated with Apgar Scores in a Review and in a New Study of Dutch Twins

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“…For this reason, statistical tests to demonstrate significance of such large differences were considered superfluous. As noted previously by Franchi-Pinto et al (1999) in newborns who remained alive, singletons have a sig- nificantly smaller proportion of Apgar scores under 7 (1 min and 5 min) than twins. For newborns who died in the first week, there were no significant differences between singletons and twins in the proportion of newborns with Apgar scores under 7 (Table VII).…”

Section: Yearsupporting

confidence: 76%

Perinatal mortality among twins and singletons in a city in southeastern Brazil, 1984-1996

Beiguelman

Franchi-Pinto

2000

Genet. Mol. Biol.

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Analysis of 116,699 deliveries (1062 twin pairs and 115,637 singletons) which occurred from 1984 to 1996 at the largest obstetric center in Campinas, SP, Brazil, provided the following conclusions: 1) despite the low percentage of twin births (0.9%), 10.7% of all early neonatal deaths and 3.5% of all stillbirths were twins. Compared to singletons, the likelihood of stillbirths and early neonatal deaths among twins was 1.9 and 6.5 times greater, respectively. 2) The proportion of twins among early neonatal deaths tended to decrease, probably because of improvements in prenatal and perinatal care.3) The critical period for early neonatal deaths in singletons and twins lasted for the three first days after birth. 4) The incidence of perinatal deaths among twins was highest among MM pairs, followed by FF pairs, and lowest among MF pairs. 5) There was a trend towards a decrease in the annual rate of early neonatal deaths among both singletons and twins, and of stillbirths among singletons, the latter being more conspicuous among females. 6) The sex ratio of singletons was practically stable among living newborns, but showed strong cyclic variation among early neonatal deaths, and a tendency to increase among stillbirths. Twins who died in the first week, as well as living twins showed a strong increase in their sex ratio from 1984 to 1996. 7) The mean gestational age of singletons was highest among living newborns followed by stillbirths, and was lowest among early neonatal deaths. The mean gestational age of living twins was higher than that of early neonatal deaths, but not different from that of stillbirths. 8) The mean birth weight of singletons and twins was highest among living newborns, followed by stillbirths, and lowest among early neonatal deaths. 9) Apgar scores ≥ 7 obtained five minutes after birth are inadequate as a reliable indicator of the clinical condition of the newborn, since almost half of the early neonatal deaths had 5-min Apgar scores varying from 7 to 10.

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“…Neste contexto, observa-se elevada taxa de mortalidade perinatal em gemelares, fortemente influenciada pelo baixo peso e prematuridade, devido à associação com desordens respiratórias, metabólicas, imunológicas e neurológicas. Soma-se aqui outro aspecto relevante que diz respeito aos índices de Apgar baixos entre os recém-nascidos gêmeos (4,5) . Quanto aos aspectos interacionais, verifica-se que a estreita relação intragemelar pode reduzir a necessidade do desenvolvimento verbal e diminuir a motivação para se comunicar, levando ao aparecimento da chamada linguagem secreta, ou seja, uma comunicação própria entre os gêmeos (6)(7)(8) .…”

Section: Introductionunclassified

Aspectos fonoaudiológicos e pediátricos na linguagem de gêmeos monozigóticos

Barbetta

Panhoca

Zanolli

2008

Rev. paul. pediatr.

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ResumoObjetivo: Observar o discurso familiar a respeito da gemelaridade, por meio de categorias inseridas nas práticas sociais, buscando subsidiar e delinear a contribuição do fonoaudiólogo e do pediatra no desenvolvimento de linguagem dos gêmeos monozigóticos.Métodos: O trabalho apóia-se no método qualitativo de pesquisa e a análise dos dados foi realizada segundo a perspectiva histórico-cultural e o paradigma de natureza indiciária. Em 30 meses, foram realizadas oito entrevistas semi-estruturadas seqüenciais, iniciadas à revelação da gestação gemelar e continuadas em intervalos aproximados de três meses até cerca de dois anos de vida dos gêmeos, com dez famílias que tinham em sua composição direta um par de gêmeos idênticos.Resultados: Sete categorias emergiram nos relatos obtidos com os familiares -a descoberta da gemelaridade, a escolha de nomes, o vestuário, a interação, a rotina, a linguagem e a identidade.Conclusões: Os depoimentos, práticas, valores e pressupostos estão relacionados com o desenvolvimento destas crianças e apontam que essas famílias precisam de um acompanhamento diferenciado e específico, desde o momento gestacional.Palavras-chave: gêmeos monozigóticos; desenvolvimento da linguagem; Pediatria; relações familiares; cuidados médicos. AbstRActObjective: To observe the way families express themselves about twins using categories related to social practices in order to help health care workers to contribute to the development of the speech of monozygotic twins.Methods: The study uses the qualitative method, based on a historic-cultural perspective and the evidential paradigm. During 30 months, eight sequential semi-structured interviews were applied to ten families who had identical twins. The interviews began when the diagnosis of the twin gestation was announced to the families and continued at approximately three-month intervals until the twins were two years old.Results: Seven categories were reported by the families during the interviews regarding the development of their twin children -announcement of the twin pregnancy, choice of names, choice of clothes, pattern of speech and identity of each child, as well as general routine and family interaction.Conclusions: There is a relationship between the development of the language in monozygotic twins and the attitudes and values reported by their families. Families of twins may need specific and differentiated follow-up since the gestational period.

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Genetic effect on apgar score

Cited by 5 publications

References 8 publications

Pre- and Perinatal Characteristics Associated with Apgar Scores in a Review and in a New Study of Dutch Twins

Pre- and Perinatal Characteristics Associated with Apgar Scores in a Review and in a New Study of Dutch Twins

Perinatal mortality among twins and singletons in a city in southeastern Brazil, 1984-1996

Aspectos fonoaudiológicos e pediátricos na linguagem de gêmeos monozigóticos

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