Ocular alkali lesions in dogs: acetylcysteine and blood serum effects

Campos, Carla Freitas; Jorge, Adriana Torrecilhas; Talieri, Ivia Carmen; Vicenti, Felipe Antônio Mendes; Toledo-Piza, Evandro de; Laus, José Luiz

doi:10.1590/s1413-95962003000100004

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…These pathological results were the primary motivation behind the selection of the NaOH alkali burn model to estimate the effects of PYC on CWH. Several treatment modalities have been estimated, containing amniotic membrane grafting [ 11 ], sub-conjunctival addition of platelet-rich plasma, topical functions of acetylcysteine [ 20 ], honey, umbilical cord serum, propolis extract, and Na-hyaluronan [ 21 ]. As previously stated [ 14 ], the group treated with PYC reduced wound size the most when compared to the untreated wounds in healthy and diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats

et al. 2022

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Aim This study aimed to investigate the efficiency of topically applied pycnogenol (PYC) in healing the standardized alkaline corneal ulcer in diabetic and normal rats. Materials and methods The corneal alkali-burn injury (CA-I) model was unilaterally developed in Wistar rats by filter paper saturated with 0.01 M of NaOH and touching the eyes for 45 s. Rats were divided into four groups: Normal control (NC), normal PYC (NPYC), diabetic control (DC), and diabetic PYC (DPYC). Both NPYC and DPYC groups were daily treated with PY eye drops three times, whereas NC and DC ones were treated with ordinary saline for six successive days. Results The wound healing of corneal epithelial was improved in the NPYC group compared to the NC group. Meanwhile, it was significantly improved (P < 0.05) in the DPYC group than in the DC group. Histological examination revealed that corneal re-epithelialization was more accomplished in the DPYC group than in the DC group. In addition, the inflammatory cells were augmented in the DC group more than those in the DPYC one. Conclusion The findings obtained revealed the efficiency of PYC for enhancing the corneal re-epithelialization and reducing the inflammatory reaction post alkali burn in rats, and thus it could be beneficially valuable as a treatment for the diabetic keratopathy.

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Section: Discussionmentioning

confidence: 99%

Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats

et al. 2022

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“…A study was carried out by Campos et al (2003), with experimentally induced corneal chemical ulcers in dogs. For the treatment, topical applied autogenous serum and 10% acetylcysteine were used.…”

Section: Discussionmentioning

confidence: 99%

The effect of intrastromal PRP and oral doxycycline in corneal wound healing after alkali burn

Charalambidou

Kofidou

Papaioannou

et al. 2019

J Hellenic Vet Med Soc

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Ocular chemical burns are among the most critical and true ocular emergencies in dogs and cats, with destructive consequences on the ocular surface and intraocular tissues. Platelet alpha granules are an important reservoir of growth factors that can stimulate chemotaxis of inflammatory cells, mitosis, migration and differentiation of cells. On the other hand, tetracyclines and their derivatives exhibit non-antimicrobial properties, such as affecting inflammation, immunomodulation, cell proliferation and angiogenesis. The objective of this study is to investigate the effect of intrastromal platelet rich plasma (PRP) in combination with oral doxycycline in the healing process of the cornea. Thirty six New Zealand rabbits were used in this experimental study. Alkali burns were created by applying a round filter paper soaked in NaOH. PRP was prepared by centrifugation of autologous blood. The rabbits were allocated to four groups (9 animals each). Group 1 served as the control group without any treatment. Group 2 received doxycycline (5mg/kg b.w.) orally once a day throughout the study. Group 3 received an intrastromal injection of PRP (0.5ml) in the cornea, and group 4 received intrastromal PRP combined with oral doxycycline. Treatments had varied levels of success, with PRP combined with oral doxycycline producing the best results regarding corneal healing. Animals in the control group had epithelial defects for the whole duration of the study, and 3 animals presented corneal perforation. Groups 3 and 4 had smaller mean defect area, compared to groups 1 and 2. On the 7th day, neovascularisation was lower in treatment groups compared to the control group. Groups 3 and 4 also had less corneal oedema compared to the control group on day 3 and 7. Group 4 exhibited the best wound healing, with less neovascularization and better collagen arrangement, as shown by the histopathological evaluation. To the authors’ knowledge this is the first experimental study that intrastromal PRP is combined with oral doxycycline for the management of corneal chemical burns. This combination is a simple, safe and economical therapeutic approach that promotes corneal healing.

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“…Segundo MAGGS (2013), os fatores que possibilitam ulcerações corneanas, e subsequentemente, o desencadeamento do processo de liquefação da córnea nos cães são os traumatismos, os corpos estranhos, a distiquíase, a ceratite seca, o entrópio, a erosão superficial da córnea, o edema crônico da córnea e as neoplasias da margem palpebral. KIM et al (2009), VONGSAKUL et al (2009), BRITO et al (2010) e CAMPOS et al (2003, complementam essa lista com a exposição a materiais nocivos, os problemas congênitos ou iatrogênicos e a deficiência na produção lacrimal de qualquer natureza.…”

Section: Introductionunclassified

Flap De Terceira Pálpebra Para Tratamento De Úlcera De Córnea Colagenolítica Difusa Em Cão: Relato De Caso

Silva¹,

Assis²,

Viana³

et al. 2015

Enciclopédia Biosfera

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RESUMO As úlceras colagenolíticas, também chamadas úlceras em Melting, úlceras de liquefação, ou ainda ceratomalácia, constituem uma alteração grave da córnea, com necessidade de intervenção rápida e agressiva, com alto risco de perda permanente da visão ou ruptura do globo ocular. São resultantes de uma destruição progressiva do estroma corneal, acarretando em fragmentação do colágeno, com liquefação e necrose da córnea. O presente estudo de caso relata a úlcera de córnea colagenolítica difusa em cão da raça Shih Tzu, a qual teve como tratamento cirúrgico o recobrimento corneal com flap simples de terceira pálpebra, com fixação palpebral, além da utilização de antibióticos, cicloplégicos e inibidor de proteases tópicos. Mesmo este não sendo a técnica cirúrgica de eleição preconizada na literatura, alcançou o sucesso terapêutico devido à progressiva recuperação da visão do paciente. PALAVRAS-CHAVE: afecção oftálmica, ceratomalácia, emergência oftálmica.

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Ocular alkali lesions in dogs: acetylcysteine and blood serum effects

Cited by 5 publications

References 6 publications

Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats

Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats

The effect of intrastromal PRP and oral doxycycline in corneal wound healing after alkali burn

Flap De Terceira Pálpebra Para Tratamento De Úlcera De Córnea Colagenolítica Difusa Em Cão: Relato De Caso

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