Retrospective review and systematic study of mammary tumors in dogs and characteristics of the extracellular matrix

Evaluation of clinical and pathological characteristics of 155 canines with mammary tumours: a retrospective study

“…And also, dysplastic or hyperplastic changes in the mammary glands are considered preneoplastic that are the initial stages in the multi-step process of tumourogenesis (Schneider et al 1969, Hellmen 1996. The low incidence of dysplastic or hyperplastic changes compared to benign and malignant tumours is in accordance with previous studies which may also be associated with the time of consultation that seems to occur late in progress of the disease (Vural and Aydın 2001, Martins et al 2002, Zatloukal et al 2005.…”

“…Various classification systems (Hampe and Misdorp 1974, Gilbertson et al 1983, Misdorp et al 1999 have been developed to estimate the prognosis of the disease. However, because of the lack of a standart criteria to differentiate benign from malignant tumours, the incidence of malignant tumours varies widely from 39 to 91 per cent according to different reports (Priester 1979, Nerurkar et al 1989, Hellmen et al 1993, Vural and Aydın 2001, Martins et al 2002, Itoh et al 2005, Zatloukal et al 2005. In the current study, the histologic ratio of malignant to benign tumours was approximately 7:3 which is in accordance with those determined in most studies (Priester 1979, Nerurkar et al 1989, Hellmen et al 1993, Vural and Aydın 2001, Martins et al 2002, Itoh et al 2005 whereas, in contrast to Misdorp et al (1999).…”

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“…Our own research in canines clearly shows that these pathologies are accompanied by significant (and to some extent are dependent on) changes starting in early development not only of myoepithelial cells but also their surrounding microenvironment, which includes the basal membrane, the amount of connective tissue and the infiltration of leukocytes [19,[55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Immunohistochemical and Histopathological Findings of Chondrosarcoma in Mammary Gland of A Dog: A Case Report

“…Primary chondrosarcoma has been reported in appendicular skeleton, synovium, trachea, larynx, lung, liver, subcutaneous, digit, tongue, kidney, abdominal wall, pulmonary artery, omentum, mammary gland, heart and urethra [2][3][4][6][7][8][9][10][11] . In veterinary literature, canine skeletal chondrosarcoma accounts for 1-13% of all chondrosarcomas [1,5] .…”