Inbred F344 rats as a biologic model of intra-abdominal sepsis

Abstract

4.7; P<0.003) and females (z > 6.2; P < 0.0003), when compared to control groups. As for MN cells, there were no differences between inoculated and control groups, in males (z = 2.3; P = 0.0107) and in females (z = 1.8; P = 0.0359) as well. In conclusion, these results show that inbred F344 rats are adequate biologic models for studies of acute, intra-abdominal sepsis.]]>

Procalcitonin, IL-1ß, HSP10 and Resolvin D2 Mechanism as Sepsis Biomarkers in Sepsis Model

“…We set an estimated 8 hours; as for the basis used by researchers is to use temperatures above 38.5°C, the number of leukocytes above 10.5x10 3 /μl and increasing levels of TNFα, and IL-1β 2 times above normal. TNFα The clinical signs of experimental animals observed to determine sepsis are piloererection, hyperpnea and decreased motor activity in the first 6 hours [21]. In this study, there were also the same signs in the first 6 hours.…”

“…Up to a 24-hour evaluation, no deaths were found. Previous studies using E. coli ATCC 11775 given intraperitoneally and evaluated at 0, 24, 48 and 168 hours [21], whereas this study did intravenously.…”