Effects of cholestyramine and lovastatin upon plasma lipids and egg yolk cholesterol levels of laying hens

Mori, Agnes Veridiana; Mendonça, Cássio Xavier de; Watanabe, Claudio

doi:10.1590/s1413-95962000000100015

Cited by 2 publications

(5 citation statements)

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“…The effect of time on yolk color was significant (p<0.05). Results related to yolk color were similar with the findings of Mori et al (2000), they reported that drug addition did not affect the shell weight, shell thickness, albumin and shell quality. The egg yolk lipid profile of the eggs collected at the end of the experiment are given in Table 3.…”

Section: Resultssupporting

confidence: 85%

“…Elkin et al (1999) reported that VLDL did not affect cholesterol levels in lovastatin or simvastatin, these researchers' findings were similar with results obtained from present study. Although Mori et al (2000) found that lovastatin with 0.005% tended to decrease the mean of triglyceride (14.9%) and total cholesterol (10.1%), Mori (2000) observed that 0.001% lovastatin caused a significant reduction of triglyceride (38.5%) and cholesterol (36.5%) levels. Kim et al (2004) reported that 0.08% of lovastatin decreased the plasma total cholesterol concentration by 28% compared to the control group.…”

Section: Resultsmentioning

confidence: 94%

“…Kim et al (2004) found that oral intake of 0.06% provastatin reduced egg cholesterol by 20% when compared to control group. Mori et al (2000) reported that lovastatin had no significant effect on egg yolk cholesterol. The lack of significant differences in present study may be due to the low proportion of lovastatin.…”

Section: Resultsmentioning

confidence: 99%

“…However, it is extremely difficult to reduce egg cholesterol levels by dietary manipulations. Genetic selection programs have resulted in only modest changes in egg cholesterol levels (Elkin and Rogler 1990;Mori et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Lovastatin Suplemented Diet on Laying Performance, Egg Quality, Yolk Lipid Profile and Some Serum Parameters in Laying Hens

Ekinci¹,

Kaya

et al. 2019

Alınteri Zirai Bilimler Dergisi

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This study was carried out to determine the effects of lovastatin supplementation on laying performance, egg quality, yolk lipid profile and some serum parameters in Lohmann LS white commercial laying hens reared in poultry houses of Food and Livestock Application and Research Center of Ataturk University. In this experiment, Lohmann layers (n=48, 46 wks of age) were randomly divided into two groups such as control (C) fed with basal diet and treatment (L) group fed with diet including 0,0059 % of lovastatin. After one week of the adaptation period, experiment lasted for five weeks. During the experimental period, hens were fed as ad-libitum and water through nipples was available for all the times. Lovastatin supplementation increased feed consumption (FC) and feed conversion ratio (FCR). Except for yolk color, other egg quality traits were not affected by diet including 0,0059 % of lovastatin. Hens fed with treatment diet had greater triglyceride and phosphatidyl serine values than hens fed with basal diet. Differences between the groups in terms of the levels of egg yolk and serum cholesterol were not significant in present study. These differences could be attributed to short experimental period and low lovastatin added to basal diet of hens. In conclusion, further studies should be conducted to clarify the effects of lovastatin supplementation on laying performance, egg quality, yolk lipid profile and some serum parameters in laying hens fed with diets including lovastatin at different levels during long feeding period.

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Lovastatin Suplemented Diet on Laying Performance, Egg Quality, Yolk Lipid Profile and Some Serum Parameters in Laying Hens

Ekinci¹,

Kaya

et al. 2019

Alınteri Zirai Bilimler Dergisi

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“…In addition, the existing publications and patents do not contain any information about the ability of lovastatin to inhibit the biosynthesis of aflatoxins. Lovastatin is nontoxic to warm-blooded animals [28][29][30] and can be microbiologically synthesized that makes its production to be relatively inexpensive. Since it was much more active towards the suppression of the AFB1 biosynthesis than other compounds studied, we investigated its effect on the AFB1 accumula-tion in wheat grain artificially infected with toxin-producing A. flavus.…”

Section: Compounds Tested As Potential Inhibitors Of the Polyketide Bmentioning

confidence: 99%

SOME NATURAL AND SYNTHETIC COMPOUNDS INHIBITING THE BIOSYNTHESIS OF AFLATOXIN B1 AND MELANIN IN Aspergillus flavus

Dzhavakhiya¹,

Voinova²,

Popletaeva³

et al. 2016

S-h. biol.

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A b s t r a c tThe control of the mycotoxin contamination of agricultural products represents a serious problem of the global food and feed industry. Aflatoxin B1 (AFB1) is one of the most dangerous mycotoxins due to its hepatotoxicity, carcinogenicity, and temperature resistance. Thus, the search for substances able to block its biosynthesis and, therefore, to prevent the toxin accumulation in food and feed is still relevant. This paper is devoted to the study of the ability of some natural and synthesized compounds to block the biosynthesis of AFB1 and/or melanin (both are secondary metabolites, which have common intermediates and common initial stages of the polyketide biosynthetic pathway) in toxigenic Aspergillus flavus. The studied compounds included lovastatin, and several commercial compounds: (aminoethyl)thiophosphonic acid, (aminomethyl)thiophosphonic acid, alafosfalin, (1-aminoethyl)phosphonic acid, and N-hydroxyputrescine. A mutant Aspergillus terreus strain 45-50 obtained earlier from the A. terreus ATCC 20542 was used as the lovastatin producer. N-hydroxyputrescine and some phosphoanalogues of amino acids were assessed by their influence on the pigmentation of fungal colonies grown on solid medium and on the specific AFB1 content in cultural broth determined after the cultivation of a fungus on liquid nutrition medium. According to the obtained results, the studied compounds were divided into three groups. To reveal changes in the colony morphology, toxigenic A. flavus strain AF11 was cultivated on agarized medium. Concentrations of tested compounds in the medium varied from 0.0001 to 0.1 % depending on their activity. To determine the effect of tested compounds on the AFB1 production, AF11 was cultivated for 170 h in a liquid Payne-Hagler medium. Solutions of the tested compounds were added to the medium up to the final concentration of 0.001-0.1 % (commercial compounds) or 0.0001 to 0.001 % (lovastatin). The efficiency of the AFB1 biosynthesis stimulation/inhibition was assessed by the comparison of its content in the cultural broth in the experimental and control (medium without additions) variants. In addition, the effect of lovastatin on the AFB1 accumulation in wheat grain contaminated with A. flavus AF11 was assessed. The performed screening allowed us to divide the studied compounds into three groups. The supplement of the nutrition medium with (aminoethyl)thiophosphonic acid, (aminomethyl)thiophosphonic acid, and alafosfalin caused a significant decrease in the AFB1 production, but did not influenced on the colony pigmentation. N-hydroxyputrescine and (1-aminoethyl)phosphonic acid were able to partially or completely block the melanin biosynthesis with the simultaneous increase in the AFB1 production. Lovastatin completely blocked both AFB1 and melanin production even at low concentrations (0.0005 %). Therefore, compounds from the first and second groups inhibit the AFB1 or melanin biosynthesis, respectively, via the blocking of stages located after the point of divergence of the correspon...

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Effects of cholestyramine and lovastatin upon plasma lipids and egg yolk cholesterol levels of laying hens

Cited by 2 publications

References 0 publications

Effects of Lovastatin Suplemented Diet on Laying Performance, Egg Quality, Yolk Lipid Profile and Some Serum Parameters in Laying Hens

Effects of Lovastatin Suplemented Diet on Laying Performance, Egg Quality, Yolk Lipid Profile and Some Serum Parameters in Laying Hens

SOME NATURAL AND SYNTHETIC COMPOUNDS INHIBITING THE BIOSYNTHESIS OF AFLATOXIN B1 AND MELANIN IN Aspergillus flavus

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