Estrus presentation and distribution in ewes treated with intravaginal sponges impregnated with medroxyprogesterone acetate (MAP) in combination with pregnant mare serum gonadotropin (PMSG)

Simonetti, Laura; Ramos, Guillermo; Gardón, Juan Carlos

doi:10.1590/s1413-95961999000500002

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…Average time to exhibit oestrus was 2.0 days (1-2.5 days). Similar time (1.9 days, 1.2-2.8 days) was reported by Simonetti et al (1999) in Merino ewes in Argentina, and by Emsen et al (2008) in fat-tailed ewes in Turkey (1.8 days, 1.2-2.8 days) treated with vaginal sponges and eCG.…”

Section: Discussionsupporting

confidence: 85%

Response of fat-tailed Syrian Awassi ewes to accelerated lambing systems

Zarkawi

2011

Trop Anim Health Prod

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Fifty cyclic fat-tailed Syrian Awassi ewes aged 2-4 years, with a mean weight of 51.4 kg, were used for 4 years to assess the accelerated lambing system (three lambings in 2 years). Ewes were divided into two groups: treated (T) and untreated (C). Ewes in the T group were treated with flugestone acetate for 14 days and injected intramuscularly at sponge withdrawal with 500 IU of equine chorionic gonadotropin (eCG). Results indicated that ewes in the T group exhibited oestrus and were mated within 5 days post sponge removal compared to 11 days for ewes in the C group, and the difference in oestrus response between the two groups was significant (P < 0.001). Repeated hormonal treatments had no significant (P > 0.05) effect on the lamb birth weight. However, significant (P < 0.001) differences in the lamb birth weight were observed between singles and multiple births. In the treated ewes, the total number of lambs born was 211-157 parturitions, and the multiple birth rate reached 27.4%, whereas the rate in the untreated group was 6.3% with the difference being significant (P < 0.05). In the untreated ewes, the total number of lambs born was 14-13 parturitions (12 singles and 1 twin). Fecundity rates were 135.1% and 106.3% in the treated and untreated ewes, respectively, and the difference was significant (P < 0.05). Repeated administration of eCG had no negative effect on fertility of Syrian Awassi ewes. However, anti-eCG antibodies were produced following eCG injections with extremely high individual differences in the immune response among ewes.

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Section: Discussionsupporting

confidence: 85%

Response of fat-tailed Syrian Awassi ewes to accelerated lambing systems

Zarkawi

2011

Trop Anim Health Prod

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“…Diante das não ocorrências de tais eventos foram consideradas como variáveis os dados relacionados à apresentação de cio e porcentagem de partos, sendo comparados os índices das ovelhas que foram submetidas ao tratamento hormonal e das que não estiveram inseridas no protocolo. Simonetti et al (1999) descreveram a distribuição da ocorrência de estro em ovelhas submetidas a utilização de protocolo com esponjas intravaginais impregnadas de Medroxiprogesterona (MAP), em seus resultados, 92,93% das matrizes apresentaram cio em menos de 72 horas. Nos estudos de Castilho et al (2013), também em relação à utilização de implantes de MAP na sincronização de fêmeas ovinas, os dispositivos foram mantidos por 9 ou 14 dias, apresentando índices de sincronização de 61% e 80%, respectivamente.…”

Section: Resultsunclassified

Efeito da progesterona exógena injetável em protocolos de sincronização em ovinos

Bretanha¹,

Carvalho²,

Nascimento³

2019

Pubvet

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Resumo. O objetivo desse trabalho foi demonstrar os efeitos da progesterona exógena injetável em protocolos de indução e sincronização de ciclo estral em ovinos. A produção desses animais mostrou-se crescente no estado da Bahia, impulsionando a necessidade de novas técnicas que aplicadas ao manejo reprodutivo aumentando a taxa de produtividade dos rebanhos. Dessa forma, foram conduzidos dois protocolos hormonais de curta duração em 17 matrizes da raça Santa Inês. Dois grupos foram submetidos à associação de Progesterona Injetável, Gonadotrofina Coriônica Equina (eCG) e Cloprostenol Sódico como precursor de Prostaglandina 2α (PGF2α), diferindo nas doses e intervalo de aplicação. Os resultados obtidos em relação a apresentação de cio não foram significativos, já os índices de parição sofreram influência negativa após o protocolo.

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“…5,6 It is intended to be used to control the timing of oestrus which allows the timing and duration of lambing to be planned. The optimum number of ewes that can be synchronized at one time is determined by the number of fertile rams available at breeding time and the number of lambings that can be handled during the compressed lambing period.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 In veterinary medicine, medroxyprogesterone acetate is used as intravaginal dosage form and is indicated for the synchronization of breeding cycle in ewes and goats. 5,6 It is intended to be used to control the timing of oestrus which allows the timing and duration of lambing to be planned. The optimum number of ewes that can be synchronized at one time is determined by the number of fertile rams available at breeding time and the number of lambings that can be handled during the compressed lambing period.…”

Section: Introductionmentioning

confidence: 99%

Analytical Method Validation of High-Performance Liquid Chromatography and Stability-Indicating Study of Medroxyprogesterone Acetate Intravaginal Sponges

Batrawi¹,

Wahdan²,

Abualhasan

2017

Anal Chem�Insights

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Medroxyprogesterone acetate is widely used in veterinary medicine as intravaginal dosage for the synchronization of breeding cycle in ewes and goats. The main goal of this study was to develop reverse-phase high-performance liquid chromatography method for the quantification of medroxyprogesterone acetate in veterinary vaginal sponges. A single high-performance liquid chromatography/UV isocratic run was used for the analytical assay of the active ingredient medroxyprogesterone. The chromatographic system consisted of a reverse-phase C18 column as the stationary phase and a mixture of 60% acetonitrile and 40% potassium dihydrogen phosphate buffer as the mobile phase; the pH was adjusted to 5.6. The method was validated according to the International Council for Harmonisation (ICH) guidelines. Forced degradation studies were also performed to evaluate the stability-indicating properties and specificity of the method. Medroxyprogesterone was eluted at 5.9 minutes. The linearity of the method was confirmed in the range of 0.0576 to 0.1134 mg/mL (R2 > 0.999). The limit of quantification was shown to be 3.9 µg/mL. Precision and accuracy ranges were found to be %RSD <0.2 and 98% to 102%, respectively. Medroxyprogesterone capacity factor value of 2.1, tailing factor value of 1.03, and resolution value of 3.9 were obtained in accordance with ICH guidelines. Based on the obtained results, a rapid, precise, accurate, sensitive, and cost-effective analysis procedure was proposed for quantitative determination of medroxyprogesterone in vaginal sponges. This analytical method is the only available method to analyse medroxyprogesterone in veterinary intravaginal dosage form.

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Estrus presentation and distribution in ewes treated with intravaginal sponges impregnated with medroxyprogesterone acetate (MAP) in combination with pregnant mare serum gonadotropin (PMSG)

Cited by 9 publications

References 6 publications

Response of fat-tailed Syrian Awassi ewes to accelerated lambing systems

Response of fat-tailed Syrian Awassi ewes to accelerated lambing systems

Efeito da progesterona exógena injetável em protocolos de sincronização em ovinos

Analytical Method Validation of High-Performance Liquid Chromatography and Stability-Indicating Study of Medroxyprogesterone Acetate Intravaginal Sponges

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