Cryptococcal meningitis in HIV-negative patient with liver cirrhosis due to hepatitis C

Miranda, Edson Jansen Pedrosa de; Gonçalves, Luiz Guilherme Cruz; França, Francisco Oscar de Siqueira

doi:10.1590/s1413-86702011000400019

Cited by 3 publications

(3 citation statements)

References 3 publications

(3 reference statements)

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“…In many cases, there is no specificity in the clinical symptoms. As we know, fungal meningitis is a common complication of immunosuppression, while Candida albicans is the most common pathogen (14,15). Overall, albicans were the most common strains followed by Candida glabrata in the clinical cases, accounting for about half of the total cases, but the source of candidemia was unknown in half of all the episodes (16).…”

Section: Discussionmentioning

confidence: 99%

Case Report: A Candida Meningitis in an Immunocompetent Patient Detected Through the Next-Generation Sequencing

Cao

Zhou

et al. 2021

Front. Med.

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Background: Fungal infections of the central nervous system (CNS) are not commonly seen clinically. Clinical diagnosis of fungal infections often depend on the pathogen culture and the clinical features. This method is time-consuming and insensitive, which can lead to misdiagnosis. The authors introduce an adult patient with fungal infections diagnosed by next-generation sequencing (NGS).Case: The patient was a 60-year-old male Chinese who had both hypermyotonia of the lower extremities and fever. The auxiliary examinations such as MRI, CT, and cerebrospinal fluid (CSF) analysis showed obvious abnormalities. Because of the difficulties in diagnosis, it was hard to determine the treatment plan. The NGS detected specific sequences of Candida albicans in 3 days. The patient was then treated with liposomal amphotericin B and fluconazole. About 3 weeks later, the symptoms of the patient improved significantly and he was discharged from the hospital.Conclusion: Compared with the routine cultural method, NGS has made a huge advancement in infection diagnosis and targeting antimicrobial therapy for CNS infection.

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Section: Discussionmentioning

confidence: 99%

Case Report: A Candida Meningitis in an Immunocompetent Patient Detected Through the Next-Generation Sequencing

Cao

Zhou

et al. 2021

Front. Med.

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“…Worldwide, about 957,900 cases of cryptococcal meningoencephalitis occur each year, resulting in more than 600,000 deaths [ 4 , 5 ]. Cryptococcal meningitis is also an important opportunistic infection in HIV-negative individuals with immunosuppression following organ transplantation, malignancy, chronic corticosteroid therapy, and chronic hepatitis C virus (HCV) infection being clinical associations [ 6 ]. Reports of cryptococcal meningitis in patients with splenectomy, or abnormalities of the function of the spleen, are largely lacking with only one detailed case report in the literature.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)

et al. 2018

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Patient: Male, 65Final Diagnosis: Cryptococcal meningitisSymptoms: FeverMedication: —Clinical Procedure: —Specialty: Infectious DiseasesObjective:Rare co-existance of disease or pathologyBackground:Cryptococcal meningitis in patients who are seronegative for the human immunodeficiency virus (HIV) and in patients who are splenectomized is rare. This report is an unusual case of meningeal and cerebellar infection due to the encapsulated yeast, Cryptococcus neoformans, which has not previously been associated with asplenia.Case Report:A 65-year-old HIV-negative patient with a previous splenectomy, presented with a three-day history of fever, vomiting, and headache. His symptoms progressed to generalized body aches, persistent fever, and neck stiffness. A lumbar puncture was performed, and cerebrospinal fluid (CSF) culture grew Cryptococcus neoformans. Treatment commenced with intravenous amphotericin B and flucytosine. The patient required serial lumbar punctures due to persistent raised intracranial pressure (ICP). Magnetic resonance imaging (MRI) of the brain showed acute meningitis and cerebellitis. Antimicrobial therapy and CSF drainage resulted in clinical improvement.Conclusions:The occurrence of meningeal and cerebellar cryptococcosis in an asplenic patient is rare, and few cases have been previously reported. This case report highlights the possibility of invasive cryptococcal infection, or cryptococcosis, in asplenic individuals in the absence of HIV infection.

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“…Ayrıca sirozda doğal ve adaptif immün yanıtta değişiklikler meydana gelmektedir. Porto-sistemik şantların gelişimi, sinüzoidal ve septal fibrozis, Kuppfer hücre sayısı ve kompleman reseptörü azalması ile birlikte kandan endotoksin klirensi azalmakta ve tüm bu değişimlerin sonucunda bakteriyemi ve ölüm hızında artış meydana gelmektedir (13)(14)(15) .…”

Section: Discussionunclassified

A Cryptococcal Meningitidis Case, HIV Negative, with Pigeon Contact

Otağ¹,

Ersöz²,

Karabıçak³

et al. 2016

TMCD

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Cryptococcal meningitis in HIV-negative patient with liver cirrhosis due to hepatitis C

Cited by 3 publications

References 3 publications

Case Report: A Candida Meningitis in an Immunocompetent Patient Detected Through the Next-Generation Sequencing

Case Report: A Candida Meningitis in an Immunocompetent Patient Detected Through the Next-Generation Sequencing

A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)

A Cryptococcal Meningitidis Case, HIV Negative, with Pigeon Contact

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