HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil

Silva, Edinete Melo da; Acosta, Angelina Xavier; Santos, Eduardo José Melo dos; Netto, Eduardo Martins; Lemaire, Denise Carneiro; Oliveira, Adriano Machado; Barbosa, Carolina Matos; Bendicho, Maria Teresita; Galvão–Castro, Bernardo; Brites, Carlos

doi:10.1590/s1413-86702010000500008

Cited by 5 publications

(7 citation statements)

References 28 publications

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“… a Four studies [50,51,52,53] with mostly negative results (not reaching statistical significance) are cited briefly in the text. b Organized by group and sorted by degree of popularity, i.e. ; the number of studies meeting criteria (see Figure 1).…”

Section: Host Genetics and Set-point Vlmentioning

confidence: 99%

“…a Four studies [50,51,52,53] with mostly negative results (not reaching statistical significance) are cited briefly in the text.…”

Section: Host Genetics and Set-point Vlmentioning

confidence: 99%

“…When HLA-Bw4-80I is present, one or more copies of KIR3DS1 was associated with relatively low set-point VL even after statistical adjustments for other known factors in the KIR-HLA interaction pathway, including HLA-B*57 , B*27 , and B*35Px [44]. Two other recent studies found no association between KIR3DL1 , KIR3DS1, or KIR2DS4 and viral load [52,53]. Differences in methodology and KIR3DS1 population frequencies may account for the lack of immediate consensus.…”

Section: Host Genetics and Set-point Vlmentioning

confidence: 99%

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HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues

Prentice

Tang

2012

Viruses

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The dynamics of HIV-1 viremia is a complex and evolving landscape with clinical and epidemiological (public health) implications. Most studies have relied on the use of set-point viral load (VL) as a readily available proxy of viral dynamics to assess host and viral correlates. This review highlights recent findings from population-based studies of set-point VL, focusing primarily on robust data related to host genetics. A comprehensive understanding of viral dynamics will clearly need to consider both host and viral characteristics, with close attention to (i) the timing of VL measurements, (ii) the biology of viral evolution, (iii) compartments of active viral replication, (iv) the transmission source partner as the immediate past microenvironment, and (v) proper application of statistical models.

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Section: Host Genetics and Set-point Vlmentioning

confidence: 99%

“…a Four studies [50,51,52,53] with mostly negative results (not reaching statistical significance) are cited briefly in the text.…”

Section: Host Genetics and Set-point Vlmentioning

confidence: 99%

Section: Host Genetics and Set-point Vlmentioning

confidence: 99%

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HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues

Prentice

Tang

2012

Viruses

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“…44 Silva et al noted an association between HLA Bw4-HLA B*57 and HLA Cw*18 with low HIV viral load in Brazilian patients. 45 A related study by Lazaryan et al demonstrated an association of low virus load and the presence of Cw*18 allele regardless of the presence or absence of the protective B*5703 allele in a Zambian subtype C HIV infected cohort. 46 HLA Bw4 and HLA C are ligands for NK cell receptors (KIRs) that stimulate cytotoxic activity of these effector cells.…”

Section: Disease Progressionmentioning

confidence: 93%

HLA Genetic Polymorphisms: Role in HIV-1 Susceptibility, Disease Progression and Treatment Outcomes

Tshabalala¹,

Morse²,

Zijenah³

2013

RRT

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Abstract:The human leukocyte antigen (HLA) gene loci are key in human immunodeficiency virus (HIV) antigen presentation leading to an immune response to infection. The high genetic variation in these gene loci forms the basis of the host's ability to mount immune responses to different viral epitopes. Polymorphisms of the HLA will impact susceptibility to HIV infection, disease progression, and treatment. This review aims at giving an overview on the role of HLA gene polymorphisms on HIV acquisition, rate of disease progression, and treatment outcomes. Understanding the HIV epitope-HLA complexes during infection might provide insight into the design of multi-epitope HIV vaccine for different populations.

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“…1,2 HLA class I have an important role in the innate and adaptive immune responses during the course of HIV-1 infection. [3][4][5] The HLA-B locus is the most HLA-I polymorphic. Based on current estimates, there are over 4859 allelic variants of HLA-B.…”

Section: Introductionmentioning

confidence: 99%

HLA-B*44 allele associated with clinical parameters in HIV-1 infected Moroccan cohort

et al. 2019

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Background: The human leukocyte antigen-B*44 (HLA-B*44) allele has been reported to have promising results in the control of human immunodeficiency virus-1 (HIV-1) infection and associated with protection against HIV-1 disease progression. In the Moroccan HIV-1 infected patients, the contribution of this allele has not been established. This study aimed to evaluate the distribution of HLA-B*44 allele among HIV-1-infected in Morocco. Additionally, investigate HLA-B*44 allele association with demographical and HIV clinical parameters.Methods: One hundred and sixty-seven HIV-1 infected, antiretroviral naive individuals were enrolled in this study. The HLA-B*44 allele screening was performed using the PCR amplification.Results: Of the 167 individuals genotyped, 26 (16%) of them expressing the HLA-B*44 allele. Clinical stages at diagnosis, median pre-treatment HIV viral load (pVL) and CD4 T cell counts differ significantly (p = 0.0001, p=0.001 and p=0.0001 respectively) between the patients who had been expressing the HLA-B*44 allele and patients who had not been expressing this allele. The presence of HLA-B*44 allele was significantly associated with pVL and CD4 T cell counts (p=0.004 and p=0.0001 respectively). The bivariate analysis has showed that the expression of the HLA-B*44 allele was strongly associated with advanced HIV infection (Odd ratio (OR) 0.12 (95% confidence interval (CI) 0.04-0.37), p=0.0001).Conclusions: Author have described for the first time in Morocco the association of the HLA-B*44 allele with the clinical parameters of HIV infection. These results expand the knowledge of the distribution and effect of this allele in the Moroccan population.

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HLA-Bw4-B57 and Cw18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil

Cited by 5 publications

References 28 publications

HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues

HIV–1 Dynamics: A Reappraisal of Host and Viral Factors, as well as Methodological Issues

HLA Genetic Polymorphisms: Role in HIV-1 Susceptibility, Disease Progression and Treatment Outcomes

HLA-B*44 allele associated with clinical parameters in HIV-1 infected Moroccan cohort

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