The epidemiology of sepsis in a Brazilian teaching hospital

Abstract

We declare no confl ict of interest. ABSTRACT Objectives:The objective of this study was to estimate disease incidence and mortality rate of sepsis in a tertiary public hospital. Methods: Patients admitted to the Intensive Care Unit (ICU) in 2004 and 2005 were monitored for sepsis using an observational longitudinal study design. Patients were monitored daily for diagnostic criteria of sepsis, according to ACCP/SCCM Consensus Conference criteria, until either death or hospital discharge. Results: During the study, we analyzed 1,179 patients. Systemic Infl ammatory Response Syndrome (SIRS) was present in 1,048 (88.9%) patients on admission, and was associated with infection in 554 (47.0%) patients. Of these, sepsis was diagnosed in 30 (2.5%) patients, while severe sepsis was diagnosed in 269 (22.8%) patients, and septic shock was diagnosed in 255 (21.6%) patients. APACHE II and SOFA scores were higher in septic patients (p < 0.001), and the ensuing mortality rates were 32.8% (IC 95%: 21.6-45.7%) for patients with sepsis, 49.9% (IC 95%: 44.5-55.2%) for severe sepsis, and 72.7% (IC 95%: 68.1-76.9%) for septic shock. Conclusions: The data from our study revealed a high incidence of sepsis among hospitalized patients. Moreover, sepsis patients had a high rate of mortality.

Sepse em Unidades de Terapia Intensiva

“…Destaca-se que a evolução para choque séptico tem sido repetidamente associada à maior mortalidade em diversos estudos com pacientes com sepse em UTI. Trabalhos nacionais demonstram mortalidade de 10,1% a 32,8% para pacientes com sepse, 22,6% a 49,9% para sepse grave, e 64,8% a 72,7% para o choque séptico, com significância estatística (Zanon et al, 2008); (Kauss et al, 2010).…”

Ações Do Enfermeiro Mediante a Percepção Da Sepse Na Unidade De Terapia Intensiva

“…A sepse é uma resposta inflamatória sistêmica desencadeada por uma infecção grave causada por um agente patológico. Trata-se de uma reação de um foco infeccioso evidente que se manifesta em diferentes aspectos de gravidade estando diretamente relacionado com o tempo da sua ocorrência (KAUSS, et al, 2017). A sepse é um problema de saúde pública mundial, sendo a principal causa de hospitalização e mortalidade em Unidades de Terapia Intensiva (UTI) com taxas variando de 20% a 80%, dependendo da definição utilizada (OKAMOTO et al, 2012).…”

ECAIS study: Inadvertent cardiovascular adverse events in sepsis

“…1 It is the main cause of death in noncoronary critical patients, with a mortality rate of between 19.6% and 59%. 2,3 Mortality in such cases is attributable to failure of different organs, including particularly the cardiovascular system. 4 The pathogenesis of myocardial dysfunction due to sepsis is of a multifactorial nature, and includes ischemia.…”