Pyogenic liver abscess caused by community-acquired multidrug resistance Pseudomonas aeruginosa

Abstract

Pyogenic liver abscess (PLA) is a very uncommon liver disease affecting predominantly young males in the setting of intra-abdominal infection.1 PLA can be caused by several organisms. An uncommon case of PLA caused by multidrug resistant (MDR) Pseudomonas aeruginosa is described.A previously healthy 28-year-old man was admitted to our clinic with a two weeks history of pain in the right upper abdomen, followed by fever, chills, and vomiting. On admission day, physical examination revealed that he was in pain and feverish (38.6° C), and had hepatomegaly. Laboratory fi ndings included total white blood cell (WBC) count of 14,800/mm 3 , erythrocyte sedimentation rate was 87 mm/h with a C-reactive protein (CRP) measuring 63 mg/dL (range, 0-8 mg/dL), and total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase were within normal limits. Abdominal ultrasonography (US) showed solid mass at right hepatic lobe, which suggested a liver abscess, according to clinical fi ndings. It was also confi rmed by abdominal computed tomography (CT). The abscess was localized with transverse CT images and percutaneous drainage with 20 Fr gauge was performed. Fluid samples were sent for microbiological cultures. He was initially treated with ceftriaxone 2 g/day plus metronidazole 1 g/day with no improvement. After three days, the aspiration culture grew MDR P. aeruginosa. The bacteriological resistance results led us to change the initial treatment to imipenem 2 g/day plus amikacin 1.5 g/day for four weeks. The patient was discharged 21 days after admission without evidence of any complication.Despite continuous improvement in image modalities, availability of potent antibiotics and advancement in the knowledge and treatment of PLA, morbidity and mortality remains high. Its incidence ranges from 0.008 to 0.0022% in hospitalized patients.2,3 The diagnosis of PLA was based on clinical fi ndings and evidence from imaging studies, either abdominal US or CT. Treatment with intravenous antibiotics and application of catheter drainage or aspiration are the primary therapeutic strategies.The most common pathogenic agents, which enter the liver by vascular routes, are Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, streptococci, and staphylococci, but anaerobes may also be present.2 Nevertheless, P. aeruginosa has long been regarded as a relatively rare pathogen of PLA, especially in patients without underlying conditions, such as lung and renal disease, malignancies, organ transplantation, immunosuppression.4 P. aeruginosa was defi ned as being MDR when the organism was resistant to all agents studied (ampicillin, amoxicillin-clavulanate, ceftriaxone, ceftazidime, cefepime, aztreonam, chloramphenicol, ciprofl oxacin, gentamicin, piperacillin, and trimetoprim-sulfamethoxazole), except imipenem, amikacin, and colistina.5 When searching Pub Med, we fi nd only one case report of PLA caused by P. aeruginosa, but it was not MDR. 4 On the other hand, PLA c...

Liver abscess caused by multidrug-resistant pathogen Stenotrophomonas maltophilia: A rare case report

“…[ 2 ] The various organisms which have been implicated in the etiopathogenesis of liver abscess are Escherichia coli, Klebsiella pneumoniae, staphylococci, enterococci, bacteroides, Corynebacterium jeikeium , microaerophilic streptococci, anaerobic streptococci, Salmonella Typhi, and Proteus vulgaris . [ 2 4 5 ] Datta et al . [ 6 ] reported the first case of liver abscess caused by Streptococcus constellatus from India (Chandigarh) in the year 2017.…”

Liver Abscess Caused by Multidrug-resistant <i>Pseudomonas aeruginosa</i> Treated with Colistin; A Case Report and Review of the Literature

“…As with Chen's study, most patients had hepatobiliary comorbidities and/or had undergone intra-abdominal procedures. Only two patients (6,10) were previously healthy. These results are compatible with our patient's situation.…”

“…Chen et al reported that only 1.86% (20/1,076 cases) of liver abscess patients are infected with P. aeruginosa (1). In past case reports (2)(3)(4)(5)(6)(7)(8)(9)(10), only one patient with a multidrug-resistant Pseudomonas aeruginosa (MDRP) liver abscess patient has been described (10).…”