Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C

Moura, Alexandre Sampaio; Carmo, Ricardo Andrade; Teixeira, Antônio Lúcio; Rocha, Manoel Otávio da Costa

doi:10.1590/s1413-86702009000500013

Cited by 22 publications

(15 citation statements)

References 130 publications

(146 reference statements)

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“…In patients with HCV infection intrahepatic expression of CCL4 and CCL5, especially in periportal and lobular areas is increased, and their levels of expression were significantly associated with the degree of liver inflammation ( Larrubia et al , 2008 ). CCL4 and CCL5 expression have also been associated with liver histological activity index in chronic hepatitis C ( Larrubia et al , 2008 ; Moura et al , 2009 ). CCL4 and CCL5 are potent chemoattractants for memory T lymphocytes, monocytes, NK cells and eosinophils, and they attract cells through an interaction with their receptor CCR5 ( Navratilova, 2006 ; Maghazachi, 2010 ; Ingelsten et al , 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma

et al. 2015

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Background:Most hepatocellular carcinomas (HCCs) are diagnosed at an advanced stage. The prognostic value of serum tumour markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) is limited. The aim of our study is to evaluate the diagnostic value of serum growth factors, apoptotic and inflammatory mediators of cirrhotic patients with and without HCC.Methods:Serum samples were collected from cirrhotic potential liver transplant patients (LTx) with (n=61) and without HCC (n=78) as well as from healthy controls (HCs; n=39). Serum concentrations of CRP, neopterin and IL-6 as markers of inflammation and thrombopoietin (TPO), GCSF, FGF basic and VEGF, HMGB1, CK-18 (M65) and CK18 fragment (M30) and a panel of proinflammatory chemokines (CCL2, CCL3, CCL4, CCL5, CXCL5 and IL-8) were measured. Chi square, Fisher exact, Mann–Whitney U-tests, ROC curve analysis and forward stepwise logistic regression analyses were applied.Results:Patients with HCC had higher serum TPO and chemokines (P<0.001 for TPO, CCL4, CCL5 and CXCL5) and lower CCL2 (P=0.008) levels than cirrhotic patients without HCC. Multivariate forward stepwise regression analysis for significant parameters showed that among the studied parameters CCL4 and CCL5 (P=0.001) are diagnostic markers of HCC. Serum levels of TPO and chemokines were lower, whereas M30 was significantly higher in cirrhotic patients than in HCs.Conclusions:High serum levels of inflammatory chemokines such as CCL4 and CCL5 in the serum of cirrhotic patients indicate the presence of HCC.

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Section: Discussionmentioning

confidence: 99%

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma

et al. 2015

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“…As the Th1 response is particularly involved in treatment responses of CHC patients, there is special interest in chemokines that are responsible for the recruitment of Th1 cells into the liver (Moura et al 2009). The most important of these chemokines are CCL2 (monocyte chemotactic protein-1), CCL3 (macrophagic inflammatory protein 1 alpha), CCL4 (macrophagic inflammatory protein 1 beta), CCL5 (regulated upon activation, normal T cell expressed and secreted), CXCL9 (monokine induced by IFN-gamma) and CXCL10 (interferon-gamma inducible protein).…”

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confidence: 99%

Soluble inflammatory markers as predictors of virological response in patients with chronic hepatitis C virus infection treated with interferon-α plus ribavirin

Moura

Carmo

Teixeira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Several biomarkers have recently been evaluated in the context of HCV infection, including interferon-responsive genes (26,30,37,40,51,53), chemokines (28,29,31,54,56), interleukin-28B (IL-28B) gene polymorphisms (16,18,39), fibrosis protein markers (6,7,35), fibrinogen-like protein 2 (11), complement component C3a (25), and osteopontin (23).…”

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Danoprevir Monotherapy Decreases Inflammatory Markers in Patients with Chronic Hepatitis C Virus Infection

Schaefer¹,

Kossen²,

Lim³

et al. 2011

Antimicrob Agents Chemother

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Danoprevir is a potent and selective direct-acting antiviral agent that targets the protease activity of hepatitis C virus (HCV) NS3/4A. This agent results in a significant rapid decline in HCV RNA levels when it is used in monotherapy. The present study evaluated whether plasma concentrations of the inflammatory markers gamma interferon-inducible protein 10 (IP-10) and neopterin or the interferon-stimulated gene product 2-5-oligoadenylate synthetase (OAS-1) were correlated with the plasma HCV RNA concentration before or during 14-day danoprevir monotherapy. In contrast to pegylated interferon and ribavirin treatment, a higher baseline IP-10 concentration was positively correlated with a greater first-phase HCV RNA decline upon danoprevir administration. Changes in the IP-10 plasma concentration during danoprevir administration were also associated with categorical changes in HCV RNA concentration at days 7 and 14. The neopterin concentration appeared to be moderately decreased during danoprevir administration, although these changes were not statistically significant. However, changes in neopterin concentration showed a statistically significant correlation with changes in IP-10 concentration. Considerable variation in the OAS-1 concentration was observed before and during treatment, including in patients treated with placebo and/or patients with minimal virologic response. Overall, these results suggest that effective treatment with a direct-acting antiviral agent may reduce hepatic inflammation and that first-phase HCV RNA decline during treatment with an NS3/4A protease inhibitor is more robust in patients with high baseline IP-10 concentrations.

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Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C

Cited by 22 publications

References 130 publications

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma

Soluble inflammatory markers as predictors of virological response in patients with chronic hepatitis C virus infection treated with interferon-α plus ribavirin

Danoprevir Monotherapy Decreases Inflammatory Markers in Patients with Chronic Hepatitis C Virus Infection

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