Pathogenic and opportunistic respiratory bacteria-induced apoptosis

Lancellotti, Marcelo; Pereira, Rosa Inês Costa; Cury, Gisele Gentile; Hollanda, Luciana Maria de

doi:10.1590/s1413-86702009000300014

Cited by 19 publications

(12 citation statements)

References 60 publications

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“…Extracellular parasitic worms, such as filarial nematodes, schistosomes, and the cestode Taenia crassiceps, can induce apoptosis in host cells (James and Green, 2004). Bacterial pathogens such as Neisseria, Chlamydia and Legionella pneumophila can either block or induce apoptosis in host cells, depending on the stage of infection (Faherty and Maurelli, 2008;Lancellotti et al, 2009). Apoptosis might even have a symbiotic origin (Kroemer, 1997).…”

Section: Discussionmentioning

confidence: 99%

Wolbachia‐induced apoptosis associated with increased fecundity in Laodelphax striatellus (Hemiptera: Delphacidae)

Guo

Hoffmann

et al. 2018

Insect Molecular Biology

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Wolbachia influence the fitness of their invertebrate hosts. They have effects on reproductive incompatibility and egg production. Although the former are well characterized, the mechanistic basis of the latter is unclear. Here, we investigate whether apoptosis, which has been implicated in fecundity in model insects, influences the interaction between fecundity and Wolbachia in the planthopper Laodelphax striatellus. Wolbachia-infected females produced about 30% more eggs than uninfected females. We used the terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling staining to visualize apoptosis. Microscopic observations indicated that the Wolbachia strain wStri increased the number of ovarioles that contained apoptotic nurse cells in both young and aged adult females. The frequency of apoptosis was much higher in the infected females. The increased fecundity appeared to be a result of apoptosis of nurse cells, which provide nutrients to the growing oocytes. In addition, cell apoptosis inhibition by caspase messenger RNA interference in Wolbachia-infected L. striatellus markedly decreased egg numbers. Together, these data suggest that wStri might enhance fecundity by increasing the number of apoptotic cells in the ovaries in a caspase-dependent manner. Our findings establish a link between Wolbachia-induced apoptosis and egg production effects mediated by Wolbachia, although the way in which the endosymbiont influences caspase levels remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Wolbachia‐induced apoptosis associated with increased fecundity in Laodelphax striatellus (Hemiptera: Delphacidae)

Guo

Hoffmann

et al. 2018

Insect Molecular Biology

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“…The adherence of this microorganism has shown not only an intimate adhesion but important alterations in the morphology of this cell line. These morphological descriptions, clearly indicate (Table 1 and Figure 1) a singular interaction between this pathogen and glia cells, it also indicates a potential of meningococcal infection and their glioma consequences in inducing the apoptosis process in these cells [17].…”

Section: Discussionmentioning

confidence: 63%

Effects of Neisseria meningitidis Infection in Tumor Glioblastoma Cell Line NG97: Respiratory Pathogen Inducing Apoptosis

Pereira¹,

Alves²,

Jacinto³

et al. 2011

J Bacteriol Parasitol

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Astrocytomas, or glioblastomas, are aggressive malignancies of the central nervous system which has poor prognosis, even when submitted to surgery, radiation and chemotherapy. Established permanent cell lines are valuable tools for the study of the glioma pathology, diagnostic and treatment. In this work, were analyzed the adhesion, induction of apoptosis and chemokines' expression of the bacterial pathogen Neisseria meningitidis in the astrocytome cell line NG97. The analysis of the adhesion and morphological alteration by optical microscopy showed significant alterations mediated by meningococci infection in NG97 cells. Scanning-electron microscopy assays demonstrated a decrease in the number of microvilli on the cell surface as well as the meningococcal adhesion to the cells matrix when compared with the non-infected NG97 cells. Cells infected with different meningococci strains revealed activation of caspase-3, an apoptotic route. Also, the induction of apoptosis in NG97 cells infected was demonstrated by an increased proinflammatory chemokines expression, such as TNFα. These data suggest that N. meningitidis is a useful tool in the war against cancer.

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“…TNF-α is an agonist of both nuclear factor (NF)-kB and mitogen-activated protein kinase (MAPK) which lead to downstream upregulation of pro-inflammatory immune functions including but not limited to; increased cell adhesion (e.g. giant cell formation) and macrophage apoptosis which are beneficial to the control of mycobacterial infections 95 – 97 . One such downstream effect is the increased expression and secretion of chemokines including RANTES and interleukin IL-8 98 – 100 .…”

Section: Discussionmentioning

confidence: 99%

Cytokine and Chemokine Concentrations as Biomarkers of Feline Mycobacteriosis

O’Halloran

McCulloch

Rentoul

et al. 2018

Sci Rep

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Mycobacteriosis is an emerging zoonotic disease of domestic cats and timely, accurate diagnosis is currently challenging. To identify differential cytokine/chemokine concentrations in serum/plasma of cats, which could be diagnostic biomarkers of infection we analysed plasma/serum from 116 mycobacteria-infected cats, 16 healthy controls and six cats hospitalised for unrelated reasons was analysed using the Milliplex MAP Feline Cytokine Magnetic Bead multiplex assay. Three cytokines; sFAS, IL-13 and IL-4 were reduced while seven; GM-CSF, IL-2, PDGF-BB, IL-8, KC, RANTES and TNF-α were elevated in mycobacteria-infected cats compared to healthy controls. However, IL-8 and KC concentrations were not significantly different from cats hospitalised for other reasons. Elevations in TNF-α and PDGF-BB may have potential to identify M. bovis and M. microti infected cats specifically while GM-CSF, IL-2 and FLT3L were increased in MTBC infected cats. This study demonstrates potential use of feline tuberculosis as a spontaneously occurring model of this significant human disease. Cytokine profiling has clear diagnostic potential for mycobacteriosis of cats and could be used discriminate tuberculous from non-tuberculous disease to rapidly inform on zoonotic risk. Future work should focus on the in-field utility of these findings to establish diagnostic sensitivity and specificity of these markers.

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Pathogenic and opportunistic respiratory bacteria-induced apoptosis

Cited by 19 publications

References 60 publications

Wolbachia‐induced apoptosis associated with increased fecundity in Laodelphax striatellus (Hemiptera: Delphacidae)

Wolbachia‐induced apoptosis associated with increased fecundity in Laodelphax striatellus (Hemiptera: Delphacidae)

Effects of Neisseria meningitidis Infection in Tumor Glioblastoma Cell Line NG97: Respiratory Pathogen Inducing Apoptosis

Cytokine and Chemokine Concentrations as Biomarkers of Feline Mycobacteriosis

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