A syphilis co-infection study in human papilloma virus patients attended in the sexually transmitted infection ambulatory clinic, Santa Casa de Misericórdia Hospital, Rio de Janeiro, Brazil

Souza, Lúcia Maria de Sena; Miller, William; Nery, José Augusto da Costa; Andrade, Arnaldo F.B.; Asensi, Marise Dutra

doi:10.1590/s1413-86702009000300010

Cited by 10 publications

(13 citation statements)

References 2 publications

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“…4 Local asymptotic stability of disease-free equilibrium co-infection model (1) The epidemiological implication of Lemma 4.1 is that when R 0 < 1, a small influx of HPV or syphilisinfected individuals into the population will not generate large HPV or syphilis outbreaks, and the diseases will die out. Modification parameter accounting for the susceptibility of syphilis-infected individuals to HPV infection 1.2 [34,35]…”

Section: Basic Reproduction Number Of the Hpv-only Sub-modelmentioning

confidence: 99%

“…Here, we assume that the cost of treatment for co-infected individuals is more than the cost of treatment for singly-infected individuals. Following the reported prevalence of Syphilis and HPV as well as the co-infection prevalence in [34, 39] and the demographic data obtained from [9], we set the initial conditions at: S (0) = 100, 000, E (0) = 10, 000, I (0) = 20, 000, L (0) = 2000, T (0) = 0, V H = 100, 000, H (0) = 2000, P (0) = 1000, C (0) = 2000, R C (0) = 0, R H (0) = 0, H E (0) = 2000, H I (0) = 10, 000, H L (0) = 10, 000, P E (0) = 1000, P I (0) = 1000, P L (0) = 1000, C E (0) = 1000, C I (0) = 10, 000, C L (0) = 5000. We implement the following four different control strategies for numerical simulations of the co-infection model 23.…”

Section: Analysis Of Optimal Control Problemmentioning

confidence: 99%

“…Epidemiological evidences have shown interactions betwen Human papillomavirus (HPV), cancer and syphilis [13,34,35,45]. Souza et al investigated the incidence of HPV-syphilis co-infection among patients in a hospital at Rio de Janeiro, Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…In a similar manner, the latent and tertiary stages of infection are referred to combined together and known as “late stage of syphilis infection”. individuals infected with syphilis infection is susceptible to infection with HPV and vice versa. [34]. individuals dually infected with HPV and syphilis can transmit either HPV or syphilis but not mixed infections.…”

Section: Introductionmentioning

confidence: 99%

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A Co-infection model for HPV and Syphilis with Optimal Control and Cost-Effectiveness Analysis

Omame

Okuonghae

Nwafor

et al. 2020

Preprint

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In this work, we develop and present a co-infection model for human papillomavirus (HPV) and syphilis with cost-effectiveness optimal control analysis. The full co-infection model is shown to undergo the phenomenon of backward bifurcation when a certain condition is satisfied. The global asymptotic stability of the disease-free equilibrium of the full model is shown \textbf{not to exist}, when the associated reproduction number is less than unity. The existence of endemic equilibrium of the syphilis-only sub-model is shown to exist and the global asymptotic stability of the disease-free and endemic equilibria of both the syphilis-only sub-model and HPV-only sub-model were established. The global asymptotic stability of disease-free equilibrium of the HPV-only sub-model is also proven. Numerical simulations of the optimal control model showed that the optimal control strategy which implements syphilis treatment controls for singly infected individuals is the most cost-effective of all the control strategies in reducing the burden of HPV and syphilis co-infections.

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Section: Basic Reproduction Number Of the Hpv-only Sub-modelmentioning

confidence: 99%

Section: Analysis Of Optimal Control Problemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Co-infection model for HPV and Syphilis with Optimal Control and Cost-Effectiveness Analysis

Omame

Okuonghae

Nwafor

et al. 2020

Preprint

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“…STI clinics can be an ideal setting for reaching these high-risk groups [21]. Studies in STI clinics have reported high prevalence estimates of HPV infection; but knowledge in patients from these settings is limited [22-24]. This study aims to describe the proportion of men that attend an STI clinic in PR who are aware of HPV, determine their level of knowledge about HPV infection, and identify correlates of HPV knowledge within this group.…”

Section: Introductionmentioning

confidence: 99%

Awareness and knowledge of Human Papillomavirus (HPV) infection among high-risk men of Hispanic origin attending a Sexually Transmitted Infection (STI) clinic

et al. 2012

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BackgroundGenital Human papilloma virus (HPV) is one of the most commonly diagnosed Sexually Transmitted Infection (STIs) in men and women. Knowledge about HPV infection among men is limited. This study aims to determine correlates of adequate knowledge of HPV infection among men who attend an STI clinic in Puerto Rico.MethodsA cross-sectional study of 206 men was conducted at an STI clinic in San Juan, PR. Adequate knowledge was defined as a score of at least 70% of correct responses among those men who reported having ever heard of HPV. Variables that achieved statistical significance in the bivariate analysis (p<0.05) were included in the multivariate logistic regression model.ResultsAlthough 52.5% of men reported having heard of HPV infection before the survey, only 29.3% of this sub-group had an adequate knowledge of HPV. Most men did not know that HPV is a risk factor for anal (38.7%), penile (50.0%) and oral (72.6%) cancer. Factors associated with adequate knowledge of HPV in age-adjusted models were being men who have sex with men (MSM) (OR=2.6;95%CI=1.1-6.1), self-report of genital warts (OR=3.2;95%CI=1.3-7.9) and herpes (OR=7.4;95% CI=2.2-25.1). MSM was marginally associated with adequate knowledge (OR=2.3;95% CI=0.9-5.9) and self-report of herpes remained significantly associated (OR=5.0;95%CI=1.3-18.4) in multivariate logistic regression analysis.ConclusionsAwareness and knowledge of HPV was very low in this group of men. Interventions to increase knowledge and awareness in this group are necessary to promote preventive practices for HPV-related cancers in high-risk groups.

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Prevalence and risk factors of anal human papillomavirus infection among men with anal condyloma acuminata by HIV status in ShenZhen, Southeast China: A retrospective cohort study

Liu,

Yang,

Huang

et al. 2023

Journal of Medical Virology

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Patients with anal condyloma acuminatum (CA) are at risk of developing anal cancer which is associated with oncogenic human papillomavirus (HPV) infection. Investigation of anal HPV prevalence and risk factors can provide effective strategies for the prevention of anal cancer. A retrospective study was conducted among 549 patients with anal CA in the Third People's Hospital of Shenzhen between January 2019 and October 2021. HPV prevalence and HIV antibodies were detected by fluorescent PCR and ELISA, respectively. Logistic regression model and structural equation modeling (SEM) were conducted to analyzed the risk factors of oncogenic HPV infection. The overall prevalence of HPV was 96.72%. Both HPV6 (N = 285, 51.91%) and HPV11 (N = 300, 54.64%) were more than half infected and the most frequent Hr‐HPV genotype was HPV16 (N = 138, 25.14%). HIV‐positive (AOR: 5.02, 95% CI: 2.98−8.60, p < 0.0001) and history of syphilis (AOR: 4.24, 95% CI: 2.31−8.46, p < 0.0001) were independent risk factors statistically associated with oncogenic HPV infection. Ever had anal sex (AOR: 3.40, 95% CI: 1.28−11.81, p = 0.0267) and age 35 years and older (AOR: 2.79, 95% CI: 1.53−5.15, p = 0.0009) were associated with HPV16 and HPV52, respectively. SEM analyses showed that HIV‐positive (b = 1.549, p < 0.001) and history of syphilis (b = 1.450, p < 0.001) had significant positive effects on oncogenic HPV infection. Ever had anal sex (b = 1.243, p = 0.025) and Age (b = 0.043, p = 0.002) positively drived HPV16 and HPV52 infection, respectively. Anal CA patients who are HIV‐positive, have a history of syphilis, or at least 35 years old should be considered for Hr‐HPV, cytology and other anal cancer related tests to reduce the risk of cancer development.

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A syphilis co-infection study in human papilloma virus patients attended in the sexually transmitted infection ambulatory clinic, Santa Casa de Misericórdia Hospital, Rio de Janeiro, Brazil

Abstract: The results demonstrated the need for a differentiated examination of all STD patients.

Cited by 10 publications

References 2 publications

A Co-infection model for HPV and Syphilis with Optimal Control and Cost-Effectiveness Analysis

A Co-infection model for HPV and Syphilis with Optimal Control and Cost-Effectiveness Analysis

Awareness and knowledge of Human Papillomavirus (HPV) infection among high-risk men of Hispanic origin attending a Sexually Transmitted Infection (STI) clinic

Prevalence and risk factors of anal human papillomavirus infection among men with anal condyloma acuminata by HIV status in ShenZhen, Southeast China: A retrospective cohort study

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