Clinical, endoscopic and prognostic aspects of primary gastric non-hodgkin's lymphoma associated with acquired immunodeficiency syndrome

Rezende, Rosamar Eulira Fontes; Mantelmacher, Marcos; Ferreira, S. E. S.; Hyppolito, Elodie Bomfim; Machado, Alcyone Artioli; Ardengh, José Celso; Modena, José Luiz Pimenta

doi:10.1590/s1413-86702009000100002

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Rezende et al,33 studying 243 HIV-positive patients submitted to upper gastrointestinal endoscopy found 6 cases of primary gastric NHL which showed a median survival time after diagnosis of 185 days.…”

Section: Discussionmentioning

confidence: 99%

Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

Harada¹,

Felipe-Silva²,

Silva³

2014

ACR

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HIV infection is known to be associated with the development of a wide range of neoplasia. About 25 to 40% of HIV-positive patients will present some kind of malignancy in the course of the disease; among them 10% are non-Hodgkin lymphomas (NHL) and 20% of these are represented by the diffuse large B-cell lymphoma. HIV-positive patients have a relative risk of 110 times higher to develop neoplasia, than the non-infected population. The gastrointestinal (GI) tract is the most frequent extranodal site of involvement. However, the primary GI lymphoma is rare. The authors present a case of a 31-year-old male patient with a 16-year history of HIV infection, who deliberately withdrew the Highly Active Antiretroviral Therapy (HAART) regimen and was hospitalized because of a respiratory infection. Because of a long-term complaint of dyspepsia, an upper gastrointestinal endoscopy was performed disclosing a large elevated and ulcerated gastric lesion, which biopsy revealed a diffuse large B-cell lymphoma. Clinical, imaging and laboratory tests showed an early stage diagnosis: Lugano stage I. Although not frequent, the authors alert to considering this neoplasia in all HIV-positive patients with dyspeptic symptoms.

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Section: Discussionmentioning

confidence: 99%

Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

Harada¹,

Felipe-Silva²,

Silva³

2014

ACR

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“…Likewise, the author affirmed that this is the first study of its sort made in Peruvian population and the first concerning survival in NHL in Latin American population, defining relevant prognosis factors such as being ART-naïve, having low albumin levels, and the tumor staging [1]. As evidence, the last research regarding NHL and its prognostic factors was made in 2009 by Rezende et al [2]; there were not following investigations that comprised these topics until Cuellar [1]. This observation is relevant because it provides a perspective of the research status in other illnesses such as KS, where there is no precedent study respecting survival or prognostic factors.…”

Section: Main Textmentioning

confidence: 91%

Letter to the editors regarding the paper: Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience

Rivera-Castillo

Quispe-Pineda

Lucchetti

2018

Infect Agents Cancer

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Non-Hodgkin Lymphoma (NHL) is a neoplasm associated with a group of malignancies called AIDs-Defining Malignancies (ADMs) in Human-Immunodeficiency Virus (HIV) -patients. Similar to the case of NHL in Latin America, particularly in Peru, the amount of research done on others ADMs is limited, especially in the case of Kaposi’s Sarcoma (KS). Prior investigations have talked about the great potential risk that represents this illness in latin american population, but topics as prognosis factors are yet to be well defined. In this letter, we address the importance of investigation in this area and include previously reported data that may enlighten the current national standpoint.

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“…NHL previously accounted for approximately 3% of AIDS-defining clinical conditions, but this proportion had declined. The incidence of PCNS lymphoma was highest; other types of lymphomas appear as case reports in the literature (Rich et al, 1992;Cappell and Botros, 1994;Rizzi et al, 2001;Doweiko et al, 2004;Khan et al, 2006;Mohan et al, 2007;Mani et al, 2008;Rezende et al, 2009;Kalogeropoulos et al, 2009;Li and Cheng, 2011). Previously, NHL accounted for approximately 3% of AIDS-defining clinical conditions, but this percentage has declined.…”

Section: The Imaging Features Of Aids-related Non-hodgkin's Lymphomamentioning

confidence: 93%

AIDS-Related Non-Hodgkin Lymphoma: Imaging Feature Analysis of 27 Cases and Correlation with Pathologic Findings

Yang¹,

Wang²,

Lv³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Some tumor types are related to HIV, including non-Hodgkin lymphoma (NHL). The morbidity and mortality of NHL has remained high, even after highly active antiretroviral therapy (HAART) was introduced. We collected cases of AIDS with NHL, and evaluated the imaging features and strategies for diagnosis. Materials and Methods: There were 27 patients with AIDS and tumors confirmed by pathology. There were 9 patients with Burkitt lymphoma, 16 with diffuse large B cell lymphomas (DLBCLs), and 2 with primary central nervous system (PCNS) lymphomas. All of the patients underwent a series of imaging studies. Three radiologists analyzed the images, and any disagreement was discussed until consensus was reached. Results: The radiologic manifestations of AIDS with NHL were mainly masses and lymphadenopathy, 3 patients having one mass and 12 two or more masses. 7 patients had lymphadenopathy in one site and 3patients had lymphadenopathy in two or more sites. Coarse mucosal folds, thickening of the gastrointestinal wall, and lumen narrowing were typical manifestations of NHL within the gastrointestinal tract. There were 4 patients with masses and 5 with lymphadenopathy inthe 9 with Burkitt lymphoma, and 11 patients with masses 5 with lymphadenopathy in the 16 with DLBCLs. Conclusion: NHL is a malignancy that usually occurs in patients with AIDS. Imaging is an important method by which to evaluate lesions, masses, and lymphadenopathy. Fine needle aspiration biopsy and stereotaxis biopsy are useful methods by which to diagnose NHL.

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Clinical, endoscopic and prognostic aspects of primary gastric non-hodgkin's lymphoma associated with acquired immunodeficiency syndrome

Cited by 6 publications

References 18 publications

Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient

Letter to the editors regarding the paper: Prognostic factors in HIV-positive patients with non-Hodgkin lymphoma: a Peruvian experience

AIDS-Related Non-Hodgkin Lymphoma: Imaging Feature Analysis of 27 Cases and Correlation with Pathologic Findings

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