Acute hepatitis due to dengue virus in a chronic hepatitis patient

Souza, Luíz José de; Coelho, José; Silva, E.J.; Abukater, Marina; Almeida, Fernanda Carlos Rodrigues de; Fonte, A. S.; Souza, Lara Assed de

doi:10.1590/s1413-86702008000500021

Cited by 14 publications

(11 citation statements)

References 5 publications

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“…It is well documented that acuteon-chronic-hepatitis can have potentially fatal consequences. There are limited data, primarily case reports, of severe dengue infections in patients with underlying chronic liver disease or those who have undergone liver transplantation [32,33]. Kittitrakul C, et al recently published a retrospective study of 127 adult patients with dengue and found abnormal AST and ALT in 88.2% and 69.3%, respectively [34].…”

Section: Clinical Relevance Of Liver Involvementmentioning

confidence: 99%

Dengue and the Liver

Ahmed¹

2015

SM J Hepat Res Treat

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An estimated 50 million dengue infections occur annually across approximately 100 tropical and subtropical countries. There is extensive clinical, biochemical, histological, radiographic, and experimental evidence of liver involvement in dengue virus infections. Transaminase elevations are commonly seen. Most cases of dengueassociated liver disease are mild. Severe acute hepatitis due to the dengue virus is uncommon. Proposed causes of liver dysfunction in dengue virus infections include a direct viral effect on hepatocytes and a dysregulated host immune response against the virus. Several avenues of future research are suggested.

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Section: Clinical Relevance Of Liver Involvementmentioning

confidence: 99%

Dengue and the Liver

Ahmed¹

2015

SM J Hepat Res Treat

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“…Our patients had markedly elevated serum transaminases at values above 10 times the upper limit of normal and the AST levels were higher than ALT as found in the few case reports of dengue associated ALF. [13] Dengue infection can cause acute damage to these non-hepatic tissue types that express AST, raised aminotransferase levels may not be entirely due to severe liver involvement. It is therefore possible that the patients with high AST levels were also more likely to be classified as severe dengue under the 2009 criteria due to the common pathways to non-hepatic tissue damage, even though there is no association with poorer outcome.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Significance of Lipid Profile With Liver Function Tests in Dengue Fever

Santhosh¹

2019

jemds

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BACKGROUND Dengue is the most prevalent mosquito borne viral infection with rapidly changing epidemiology over the last few years. Lipoproteins play a pathophysiological role in the hosts immune response to severe infection. The need to know the lipoprotein status in dengue fever, find its correlation with severity, liver function tests, and clinical outcome are the objectives of this study. METHODS This prospective observational study was taken up involving 50 adults diagnosed with dengue fever between December 2013 to December 2014 in Mysore Medical College. Patients were classified based on severity of dengue fever (DF), dengue haemorrhagic fever (DHF), dengue shock syndrome (DSS). Fasting lipid profile, liver function test (LFT), complete blood count were estimated on day 1 and day 5 of admission. RESULTS The study population comprised of 50 dengue sero positive cases. The total cholesterol was greatly reduced and LFT alterations were seen highest in DSS group. During admission, serum cholesterol and liver enzymes showed statistically significant difference in their mean concentrations in the three groups of dengue infection. The spearman correlation analysis shows that AST and total cholesterol had negative correlation (r=-0.782; p <0.01), whereas ALT and cholesterol also showed similar correlation (r=-0.738; p< 0.01). CONCLUSIONS Total cholesterol, HDL and LDL of dengue fever cases were significantly reduced at admission in comparison to the second estimation on day 5. Mean cholesterol, triglyceride and LDL levels showed statistically significant (p value <0.05) changes with severity of dengue. LFT was correlated with the severity of dengue fever. These abnormal values may serve as indicators for recognizing patients at increased risk for DHF and DSS, thus serving as prognostic markers of the dengue infected individuals.

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“…This observation was similar to the findings observed in various case reports on dengue associated ALF. [12][13][14][15][16][17][18][19][20] Myocarditis was the second leading cause of death due to dengue virus infection. Dengue virus infection is known to produce myocarditis but the exact frequency of occurrence is unknown [7,8].…”

Section: Discussionmentioning

confidence: 99%

Review of Dengue Deaths: Acute Liver Failure as a Major Cause of Mortality

Thulaseedharan¹,

Kumar²,

Thomas³

et al. 2016

jebmh

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BACKGROUNDDengue fever is a mosquito-borne viral disease endemic in many tropical and sub-tropical countries. The annual average number of dengue fever cases reported has increased dramatically in recent years. The analysis of deaths due to dengue fever will help in sensitizing treating physicians to reduce mortality in future. Aim of the study to determine the causes of mortality in dengue fever. MATERIALS AND METHODSRetrospective analysis of deaths due to dengue fever was carried out in a tertiary care centre in North Kerala. The study period was from 1 st June to 31 st December, 2015, during a major dengue epidemic. The data was collected from the hospital records using a pre-designed proforma. RESULTSThere were 22 deaths among a total of 2525 confirmed cases of dengue fever. Acute liver failure (ALF) was the major cause of death, observed in 7 patients. All the patients with ALF had serum transaminase levels more than 30 times the upper limit of normal with mean AST to ALT ratio of 1.6:1. Five patients with acute liver failure had hepatomegaly. Five deaths occurred due to myocarditis, which was the second major cause identified. Other causes were major bleeding (4 cases), encephalitis (3 cases), dengue shock syndrome (2 cases) and acute respiratory distress syndrome (1 case). CONCLUSIONSAcute liver failure was the leading cause of mortality in dengue fever. Hepatic sinusoidal endothelial damage resulting in sinusoidal obstruction is a possible mechanism; supported by the observation that majority of patients with ALF had hepatomegaly. Dengue virus infection should always be considered as a differential diagnosis of acute liver failure in endemic areas. Other fatal complications of dengue fever were myocarditis and major bleeding.

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Acute hepatitis due to dengue virus in a chronic hepatitis patient

Abstract: We present a case of acute hepatitis caused by dengue virus, with a significant increase in aspartate transferase and alanine transferase levels in a chronic hepatitis patient attended at the Cane Sugar Planters Hospital of Campos dos Goytacazes, RJ.

Cited by 14 publications

References 5 publications

Dengue and the Liver

Dengue and the Liver

Comparison of Significance of Lipid Profile With Liver Function Tests in Dengue Fever

Review of Dengue Deaths: Acute Liver Failure as a Major Cause of Mortality

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