Multidrug-resistant urinary tract isolates of escherichia coli from Ribeirão Preto, São Paulo, Brazil

Abstract

Multiple resistances to antimicrobial drugs arising in Escherichia coli isolates may complicate therapeutic management of urinary tract infection (UTI) by this organism. In order to assess the multidrug resistance (MDR) among urinary E. coli isolates, we have tested 11 antimicrobial drugs against 67 isolates from outpatients attended in a tertiary-care teaching hospital and of 78 isolates from a municipal health unit, respectively in Ribeirão Preto, State of São Paulo, Brazil. Seventy-six percent and 22% of the isolates from the tertiary-care hospital and the municipal unit, respectively, were resistant to three or more different classes of agents, and were considered to present MDR. Among the isolates from the hospital patients, 73.0%, 65.0%, 58.0%, 58.0% and 31.0% were resistant to tetracycline, ampicillin, cephalothin, trimethoprim-sulfamethoxazole (TMP/SMX) and norfloxacin, respectively; resistance from the municipal unit patients were 31.0%, 37.0%, 8.0%, 29.0% and 12.0% respectively, to the same drugs. The predominant phenotype among the MDR isolates presented is ampicillin, TMP/SMX and tetracycline resistance. The high prevalence of drug resistance among UTI patients calls for continuous surveillance to assure effective control of this infection.

Multidrug resistant Escherichia coli strains isolated from urine sample, University of Gondar Hospital, Northwest Ethiopia

“…However, in our study the situation becomes escalated to 92.9%. Besides, with reference to previous reports, E. coli isolates were found to be highly resistant to commonly prescribed antibiotics, such as AMP, cotrimoxazole, C, GEN, and CTZ [8,[20][21][22][23], which shows an agreement with the results reported in this study. Therefore, these antibiotics should not be recommended as a first line to treat UTIs.…”

“…Specifically, it showed that high prevalence of MDR E. coli isolates identified from patients with UTI was 92.9% (95% confidence interval: 87.3%-97.7%). The rate of MDR E. coli demonstrated in this study was much higher than findings from developed countries [8][9][10], but comparable to published data from low income countries [4,5,11,12]. However, few reports from developing countries documented lower prevalence of MDR E. coli as compared to this study [13][14][15][16].…”

A Single-Center Experience of Antimicrobial Resistance Patterns in Pediatric Urinary Tract Infection

“…However, they can be used in complicated UTI as they decrease hospitalization time [18] . In longitudinal studies, prevalence of ciprofloxacin resistance increased over time [3,19] , reaching almost 20% in countries such as Spain and Portugal [3] . The prevalence of ciprofloxacin resistance seems to be higher in Latin America [3,18] .…”

Antibiotic resistance in uropathogenic Escherichia coli isolated from urinary tract infections out-patients in Kermanshah

“…Therefore it is necessary to have updated knowledge of causal bacteria and their susceptibility patterns for proper selection and use of antibiotics as well as for an appropriate prescribing guideline. [4] It is hoped that the information gained from this study would help in the treatment of cases of UTI in our area. Antibiotic susceptibility pattern differences seen between countries and also different medical regions within every country.…”