CCR5 genotypes and progression to HIV disease in perinatally infected children

Angelis, Daniela Souza Araújo de; Freire, Wilton S.; Pannuti, Cláudio Sérgio; Succi, Regina Célia de Menezes; Machado, Daisy Maria

doi:10.1590/s1413-86702007000200004

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…The more you move away from the old Viking lands, the lower you see the frequency. Different selective pressures in different populations such as smallpox might have made it possible to see higher frequencies in Europe [ 10 , 14 , 21 ]. Only 2–3% of the white population is CCR5-Δ32/CCR5-Δ32.…”

Section: Discussionmentioning

confidence: 99%

“…The DNA amount used was around 10 ng. The PCR protocol was the same as Angelis et al [14]. A homozygous WT individual will only display the 189 bp band, a heterozygous individual will display both the 189 and the 157 bp band, and a homozygous mutant individual will only display the 157 bp band.…”

Section: Molecular Genotypingmentioning

confidence: 99%

“…However, this resistance is not absolute and is only for the M-tropic HIV strains. These individuals will not have the same resistance towards the T-tropic HIV strains [8,10,14]. Additionally, people who are heterozygous for the CCR5-Δ32 allele will show a slower progression to AIDS when compared to homozygous WT individuals [1].…”

Section: Introductionmentioning

confidence: 99%

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CCR5-Δ32 gene variant frequency in the Turkish Cypriot population

2020

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Recent UNAIDS reports (December 2019) indicate that 37.9 million people have been affected by HIV infection around the globe in 2018, of which 1.7 million are cited as new infections. Human immunodeficiency virus-1 (HIV-1) requires both the CD4 receptor, as the primary receptor, and a chemokine co-receptor to gain entry into the cell. In addition to the WT allele for CC motif chemokine receptor 5 (CCR5-wt), there is another allele with a 32 bp deletion in the protein coding region (CCR5-Δ32). Individuals who are homozygous for the mutant allele are resistant towards M-tropic HIV infections. In the current study, we aimed to determine the CCR5-Δ32 allele frequency in the Turkish Cypriot population with 326 subjects, 141 men (43.1%) and 185 (56.9%) women. The region of the CCR5 gene containing the Δ32 deletion was amplified using flanking primers. The CCR5 gene Δ32 allele frequency was calculated at 3% and only observed in heterozygous individuals. We hope that our current publication could be a point of dialog between the physicians, the government officials and the public set up a more modern and well-structured HIV screening program in an effort to control and hopefully eliminate HIV from the Turkish Cypriot population.

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Section: Discussionmentioning

confidence: 99%

Section: Molecular Genotypingmentioning

confidence: 99%

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CCR5-Δ32 gene variant frequency in the Turkish Cypriot population

2020

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“…The PCR protocol was same as Angelis et al. 16 A homozygous wt individual will only display the 189 bp band, a heterozygous individual will display both the 189 and the 157 bp band and a homozygous mutant individual will only display the 157 bp band.…”

Section: Methodsmentioning

confidence: 99%

CCR5-Δ32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

Ndikom¹,

Ergören²,

Sayan³

et al. 2022

Afr H. Sci.

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Background: The cystine-cystine chemokine receptor 5 (CCR5) is the primary HIV co-receptor involved in the viral entry process into human cells. The 32 bp deletion variant within the CCR5 gene (CCR5-Δ32) plays a very important role in viral recognition and progression of AIDS. Objective: The current study was aimed at evaluating the CCR5-Δ32 gene variation frequency in Nigerian and Zimbabwean populations residing in Northern Cyprus. Methods: A total number of 211 subjects (103 Nigerians and 108 Zimbabweans) were analyzed. Nigerian population was further analyzed with respect to the three major ethnicities: Igbo, Hausa, and Yoruba. Polymerase Chain Reaction was used to determine the CCR5-Δ32 gene variant status. Results: All studied subjects from both sampling groups were homozygous for the CCR5 wild type gene (CCR5–wt), meaning neither heterozygous nor homozygous genotypes of CCR5-Δ32 gene variant were observed.Conclusion: This study observed the absence of CCR5-Δ32 deletion gene in the Nigeria and Zimbabwean populations living in Northern Cyprus. These populations lack the genetic advantage over HIV infection and may also show a rapid progression towards AIDS. Additionally, these populations could impact the local gene frequency as these two populations interact more and more. Keywords: CCR5-Δ32; HIV; Nigerian; Zimbabwean; CCR5; North Cyprus.

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Systems biology and the host response to viral infection

Tan

Ganji

Paeper³

et al. 2007

Nat Biotechnol

124

118

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Will our increasing understanding of virus-host interactions translate into a new generation of antiviral therapeutics or steer us toward an expensive journey to nowhere?Systems biology. . . is about putting together rather than taking apart, integration rather than reduction. It requires that we develop ways of thinking about integration that are as rigorous as our reductionist programmes, but different. . . . It means changing our philosophy, in the full sense of the term 1 .

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CCR5 genotypes and progression to HIV disease in perinatally infected children

Cited by 8 publications

References 20 publications

CCR5-Δ32 gene variant frequency in the Turkish Cypriot population

CCR5-Δ32 gene variant frequency in the Turkish Cypriot population

CCR5-Δ32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

Systems biology and the host response to viral infection

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