The use of monoclonal antibody (Rituximab) in the treatment of type II mixed cryoglobulinemia

Rego, Thiago Carlos Gonçalves; Massumoto, C M; Siqueira-Batista, Rodrigo; Moura, Larissa Hanauer de; Soares, Lygia Maria Costa; Gomes, Andréia Patrícia

doi:10.1590/s1413-86702007000100038

Cited by 6 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В зависимости от генотипа вируса выбирают безопасные противовирусные препараты прямого действия с компонентами, ингибирующими NS3/4A (глекапревир, гразопревир, нарлапревир, паритапревир), NS5A (велпатасвир, даклатасвир, ледипасвир, омбитасвир, пибрентасвир, элбасвир) или NS5B (дасабувир, софосбувир), или используют пангенотипные препараты, эффективные при всех генотипах вируса [36]. Клинические случаи, в которых указана терапия ХВГС, описаны в период с 1993 по 2013 г., в связи с чем большинству пациентов терапия ХВГС проводилась интерфероном-α [7,11,12,15] и интерфероном-β [14]. У 1 пациента при терапии интерфероном-α описан побочный эффект в виде прогрессирующей тромбоцитопении [6].…”

Section: Discussionunclassified

“…По критериям включения/исключения в обзор были включены и проанализированы 13 клинических случаев УВ, ассоциированного с ХВГС (рис. 1, приложение 1) [6][7][8][9][10][11][12][13][14][15][16][17]. Все клинические случаи были оценены по стандартизированным шкалам (JBI checklist) (приложение 2).…”

Section: дерматологияunclassified

See 1 more Smart Citation

Urticarial vasculitis in patients with chronic hepatitis C virus as an interdisciplinary problem

Teplyakova¹

2023

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

Urticarial vasculitis is a skin disease characterized by recurrent urticarial lesions and histological features of leukocytoclastic vasculitis. Urticarial vasculitis is known to occur in the association with various infectious diseases, including chronic hepatitis C virus. However, the clinical features of urticarial vasculitis associated with hepatitis C virus have not been systematically characterized, which complicates the management of these patients. This review presents an analysis of published clinical, histological and laboratory findings in patients with urticarial vasculitis in the association with chronic hepatitis C virus, which can be helpful for early diagnosis and optimization of the patient management. We performed a Pubmed search to identify clinical cases from 1971 to 2022 using the keywords "urticarial vasculitis", "hepatitis C virus infection". According to the inclusion/exclusion criteria, 13 clinical cases of urticarial vasculitis associated with hepatitis C virus were included in the analysis. Clinical manifestations were urticarial rashes (n=13), associated with residual hyperpigmentation in 8 patients, tenderness/burning ― in 7 patients, and a lesion duration (24 hours) ― in five patients. Arthralgias were described in 3 patients. On histological examination, there were fibrinoid necrosis (n=2); leukocytoclasia (n=4); erythrocyte extravasation (n=1); dermis edema (n=2); perivascular infiltrate consisting of neutrophils (n=5), eosinophils (n=4), lymphocytes (n=3), and histiocytes (n=2). Hypocomplementemia was reported in eight patients. The laboratory work revealed cryoglobulinemia (n=9) and positive rheumatoid factor (n=6), which were the characteristic findings in the association of these diseases. The association of urticarial vasculitis and chronic hepatitis C virus is an important interdisciplinary problem that requires an interaction of dermatologists, allergists, hepatologists, rheumatologists and infectious disease doctors. Histological examination is indicated to differentiate between urticaria and urticarial vasculitis in patients with atypical urticarial lesions. Early detection of chronic hepatitis C virus is necessary for the timely administration of antiviral therapy. The urticarial vasculitis treatment should be selected taking into account their efficacy and the risk of hepatotoxicity.

show abstract

Section: Discussionunclassified

Section: дерматологияunclassified

Urticarial vasculitis in patients with chronic hepatitis C virus as an interdisciplinary problem

Teplyakova¹

2023

Russian Journal of Skin and Venereal Diseases

View full text Add to dashboard Cite

show abstract

“…The pathogenetic mechanisms underlying avWD include [1] inhibition of vWf function and/or increased clearance of FVIII-vWf complex due to autoantibodies to vWf or FVIII; [2] increased clearance of the FVIII-vWf complex due to the adsorption of vWf to malignant cells; and [3] cell-mediated or drug induced proteolysis of vWf multimers. This present case report is probably the first case of avWD associated with CG [2].…”

Section: Discussionmentioning

confidence: 99%

“…Mixed cryoglobulinemia can be essential (idiopathic) (EMC) or secondary to infections, inflammatory or neoplasic processes. EMC is a rare vasculitic syndrome that provoke various symptoms such as purpura, arthralgias, neuropathies, hepatic and renal involvement [1].…”

Section: Introductionmentioning

confidence: 99%

A case of essential mixed cryoglobulinemia and associated acquired von-Willebrand disease treated with rituximab

Paşa

Altıntaş

Çil

et al. 2008

J Thromb Thrombolysis

View full text Add to dashboard Cite

Current treatment options of essential mixed cryoglobulinemia (EMC); include immunosuppressive approaches, such as corticosteroids, cyclophosphamide, plasma exchange, other cytotoxic drugs in moderate to severe manifestations. Some controlled studies have been carried out to assess the efficacy of anti-CD20 monoclonal antibody, rituximab in patients with hepatitis C (HCV) related cryoglobulinemia (CG) and in patients with autoimmune disorders. Recent trials and some case reports demonstrate a beneficial role for rituximab in HCV related mixed CG. Although, the published evidence for treatment of EMC with rituximab is restricted to case reports, which have shown positive results. Several diseases include lymphoproliferative and myeloproliferative disorders, solid tumors, immunological disorders, cardiovascular disorders and some drugs associated with acquired von Willebrand disease (avWD). CG, which is a kind of immune complex disease, may be related with development of autoantibodies to various autoantigens. In this present case report, we showed the efficacy of rituximab in a 21-year-old female patient, suffered from neuropathy and arthralgia related with EMC, and developed avWD, presented with mucosal bleeding associated with CG. von Willebrand factor activity of our patient also increased with controlling the underlying disease, EMC by rituximab. This case demonstrate that rituximab may be an effective treatment option in EMC and avWD mainly related to CG.

show abstract

“…Rituximab therapy has been reported to be effective in type II cryoglobulinemia. 5 Because the lymphoplasmacytic cells that are the source of the monoclonal IgM protein strongly express CD20, this is a logical choice and its effectiveness has been demonstrated in corticosteroid failures. In this issue of Blood, Saadoun and coworkers studied 21 patients and demonstrated that, before therapy, there were dramatic reductions in CD19 ϩ cells, increased numbers of memory B cells, and a high number of lymphoplasmacytic cells, and demonstrate the ability of rituximab to bring these abnormalities back to the normal range.…”

mentioning

confidence: 99%

Critiquing Cryos

Gertz¹

2008

Blood

View full text Add to dashboard Cite

The use of monoclonal antibody (Rituximab) in the treatment of type II mixed cryoglobulinemia

Cited by 6 publications

References 8 publications

Urticarial vasculitis in patients with chronic hepatitis C virus as an interdisciplinary problem

Urticarial vasculitis in patients with chronic hepatitis C virus as an interdisciplinary problem

A case of essential mixed cryoglobulinemia and associated acquired von-Willebrand disease treated with rituximab

Critiquing Cryos

Contact Info

Product

Resources

About