Clinical tomographic correlations of 220 patients with neurocisticercosis, Bahia, Brazil

Andrade-Filho, Antônio de Souza; Figuerôa, Luiz Frederico da Silva; Andrade-Souza, Victor Mascarenhas

doi:10.1590/s1413-86702007000100025

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Seizures and neurodeficits have been associated more commonly with the colloidovesicular stage of neurocysticercosis because of the stimulation of the immune system by the parasite, local inflammatory reaction, and the surrounding perilesional edema. 30 The seizure semiology showed significant agreement with neuroimaging-based lateralization and a 100% positive predictive value. Seizure semiology is topographically related to the neurocysticercosis lesion in 85% of the cases.…”

Section: Discussionmentioning

confidence: 77%

Seizure Semiology, Location of Lesion on Neuroimaging, and Interictal Electroencephalographic (EEG) Abnormalities in Children With Single-Lesion Neurocysticercosis—Is There a Correlation?

et al. 2022

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Background Single-lesion neurocysticercosis provides a model of seizure genesis secondary to an acquired lesion. We aimed to study the correlation of seizure semiology with the location of the lesion and interictal electroencephalographic (EEG) abnormalities in children with single-lesion neurocysticercosis. Methods: Prospective, observational study in children with single-lesion neurocysticercosis and seizures. Seizure classification was done after an interview with the parent/onlooker and the child. Localization and lateralization of the lesion were done by neuroimaging. The EEG abnormalities were classified based on their morphology and location. Results: Ninety-two children (7.9 ± 2.4 years) were included. Focal-onset seizures were the commonest (n = 54; 58.6%) seizures. Majority of the lesions were located in the frontal (n = 43; 47%) and parietal cortex (n = 34; 37%). EEG showed focal slowing (n = 15; 53.6%) and epileptiform spikes/spike-wave complexes (n = 13; 46.4%). There was a perfect agreement of clinical semiology with imaging lateralization (K = 1.0) and moderate agreement with imaging localization (K = 0.4). There was no significant agreement of clinical localization with EEG slowing (K = 0.1) or sharps (K = 0). There was moderate agreement (K = 0.6) of EEG slowing and substantial agreement (K = 0.7) of EEG sharps with clinical lateralization. Focal EEG slowing had moderate (K = 0.5) agreement with imaging lateralization. Focal sharps/spikes had substantial (K = 0.7) agreement with imaging lateralization. The positive predictive value (PPV) of seizure semiology for lateralization and localization was 100% and 68%, respectively. PVV of focal sharps for lateralization and localization was 84% and 70%, respectively. PPV of focal slowing for lateralization and localization was 77% and 65%, respectively. Conclusion: Seizure semiology in single-lesion neurocysticercosis correlates very well with lateralization but not so well with localization of lesion on neuroimaging. Focal EEG abnormalities are seen in nearly one-third of children with single-lesion neurocysticercosis. EEG often predicts the side of the lesion but has poor localizing value.

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Section: Discussionmentioning

confidence: 77%

Seizure Semiology, Location of Lesion on Neuroimaging, and Interictal Electroencephalographic (EEG) Abnormalities in Children With Single-Lesion Neurocysticercosis—Is There a Correlation?

et al. 2022

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“…Additional tests included: 12 patients had a CT; four had an MRI; and six had a CT and an MRI. According to several studies, the vital stages of metacestode larvae of Taenia solium in the cranial cavity were estimated according to the appearance on imaging exams 6,11,12 . Although all patients in the neurocysticercosis group presented active lesions, the pattern of larval imaging was heterogeneous in 13 (59.1%) patients, 8 of which displayed vesicular and calcified forms; two showed colloidal and granular phases; one presented both vesicular and granular aspects; one presented vesicular and colloidal forms; and one presented vesicular, granular and calcified forms.…”

Section: Carvalho-junior Rm Et Al -Enzyme Immunoassay For Diagnosis Omentioning

confidence: 99%

Evaluation of an enzyme immunoassay for clinical diagnosis of neurocysticercosis in symptomatic patients

Carvalho

Costa

Soares³

et al. 2010

Rev. Soc. Bras. Med. Trop.

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Introduction: Neurocysticercosis is an infection of the human central nervous system caused by the metacestode larvae of Taenia solium. Neurocysticercosis is the most common parasitic disease in developing countries. Epilepsy is the most common clinical manifestation. Difficulties in confirming the diagnosis motivated the evaluation of the enzyme-linked immunosorbent assay on cerebral spinal fluid (CSF). Methods: Twenty-two patients with NCC and 44 control patients were studied. CSF was analyzed using a commercial ELISA kit developed for NCC. Sensitivity and specificity were measured and a multivariate logistic regression was performed. Results: Sensitivity and specificity of ELISA were 31.8% and 100%, respectively, with accuracy of 77.3%. Only the size of the lesions proved to be important for performance of the test. Conclusions:The results showed that ELISA contributes to the diagnosis of neurocysticercosis if the result is negative or if the patient has a lesion of 2 cm or more.

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“…In Brazil, the greatest prevalence of NCC is found in the states of Paraná, São Paulo, Minas Gerais, Rio de Janeiro and Bahia. 11 …”

Section: Introductionmentioning

confidence: 99%

Frontotemporal dementia and neurocysticercosis: a case report

Satler

Maestro

Tomaz

2012

Dement. neuropsychol.

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ABSTRACT. We report a case of a 67-year-old woman with frontotemporal dementia (FTD) and a history of neurocysticercosis. After her retirement she showed progressive behavioral changes and neuropsychiatric symptoms with relative preservation of cognitive functioning. During the next three years, the patient manifested progressive deterioration of verbal communication gradually evolving to mutism, a hallmark of cases of progressive nonfluent aphasia. Key words: progressive nonfluent aphasia, neurocysticercosis, neuropsychological assessment, frontotemporal lobar degeneration. DEMÊNCIA FRONTOTEMPORAL E NEUROCISTICERCOSE: UM RELATO DE CASORESUMO. Caso de uma mulher de 71 anos com demência frontotemporal e historia de neurocisticercose. Após sua aposentadoria ela apresentou progressivas mudanças comportamentais e sintomas neuropsiquiátricos, com relativa preservação do funcionamento cognitivo. Durante os seguintes três anos, a paciente foi desenvolvendo uma deteriorização progressiva da comunicação verbal evoluindo gradualmente a mutismo, marca que descreve um caso de afasia progressiva não fluente. Palavras-chave: afasia progressiva não fluente, neurocisticercose, avaliação neuropsicológica, degeneração lobar frontotemporal

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Clinical tomographic correlations of 220 patients with neurocisticercosis, Bahia, Brazil

Cited by 5 publications

References 16 publications

Seizure Semiology, Location of Lesion on Neuroimaging, and Interictal Electroencephalographic (EEG) Abnormalities in Children With Single-Lesion Neurocysticercosis—Is There a Correlation?

Seizure Semiology, Location of Lesion on Neuroimaging, and Interictal Electroencephalographic (EEG) Abnormalities in Children With Single-Lesion Neurocysticercosis—Is There a Correlation?

Evaluation of an enzyme immunoassay for clinical diagnosis of neurocysticercosis in symptomatic patients

Frontotemporal dementia and neurocysticercosis: a case report

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