Fatal case of bacteremia caused by an atypical strain of Corynebacterium mucifaciens

Cantarelli, Vlademir Vicente; Brodt, Teresa; Secchi, Carina; Inamine, Everton; Pereira, Fabiana de Souza; Pilger, Diogo André

doi:10.1590/s1413-86702006000600013

Cited by 7 publications

(4 citation statements)

References 7 publications

(13 reference statements)

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“…For many years, these organisms were disregarded as skin contaminants [7]. However, they have been recognized as important human pathogens, often acting as opportunistic pathogens in immunocompromised or severely-ill patients with symptoms compatible with bacteremia and without presence of other pathogenic organism [1-3,8]. Thus, eight strains of one of these new species had previously been isolated from human relevant clinical material.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, these organisms have been increasingly implicated in serious infections and a fatal case of bacteremia due to an atypical strain of C. mucifaciens has been recently reported in an elderly Brazilian severely-ill woman [8]. Thereby, potential critical issue is stressing the importance for rapid and accurate laboratory identification and susceptibility testing of such unusual pathogens that might improve treatment and outcome of associated infection.…”

Section: Discussionmentioning

confidence: 99%

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Corynebacterium mucifaciensin an immunocompetent patient with cavitary pneumonia

Djossou

Bezian²,

Moynet

et al. 2010

BMC Infect Dis

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BackgroundCorynebacterium mucifaciens has been mainly isolated from skin, blood and from other normally-sterile body fluids. It has rarely been described as a human pathogen since its description.Case presentationWe herein report the first case of cavitary pneumonia due to C. mucifaciens in an immunocompetent man returning from Maghreb.ConclusionC. mucifaciens should be considered as important human pathogen in patients with severe illness and compatible history of exposure even in individuals with no clearly identified immunosuppression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Corynebacterium mucifaciensin an immunocompetent patient with cavitary pneumonia

Djossou

Bezian²,

Moynet

et al. 2010

BMC Infect Dis

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“…To our knowledge, several bacteria isolated in this study are pathogens capable of causing bacteremia, such as Brevundimonas vesicularis, Acinetobacter pittii, and Exiguobacterium aurantiacum; however, these pathogens were all discovered in nosocomial infections [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63]. Other nosocomial infections associated with our isolates were ventriculoarterial shunt infection caused by Staphylococcus warneri [64], pneumonia caused by Acinetobacter pittii [65], and line-related sepsis caused by Delftia acidovorans [66].…”

Section: Pseudomonas Synxantha 12mentioning

confidence: 93%

Bacterial Microbiota in Unfed Ticks (Dermacentor nuttalli) From Xinjiang Detected Through 16S rDNA Amplicon Sequencing and Culturomics

Song

Sun

et al. 2021

Zoonoses

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Background: Ticks are a major arthropod vector of zoonotic diseases affecting both humans and domestic animals worldwide. Thus, studying tick microbiota would aid in understanding of the potential threats posed by ticks. Methods: Approximately 8,000 unfed ticks, identified as Dermacentor nuttalli, were collected from the sylvosteppe in the western Tianshan mountains. To investigate their potential pathogens, we divided the ticks into 36 groups of 200–300 individuals each for examination with culturomics and 16S rDNA amplicon sequencing. Results: A total of 237 bacterial genera were identified with the two methods. Culturomics identified 46 bacterial species from 23 genera, predominantly Pseudomonas, Pantoea, and Bacillus, whereas 16S rDNA sequencing identified 461 OTUs from 233 genera, predominantly Pseudomonas (53.8%), Coxiella (17.2%), and Pantoea (6.4%). Coxiella, Rickettsia, and ten other genera were discovered only by sequencing, because optimal cultivating conditions were not used for their isolation, whereas Arthrobacter and three other genera were discovered only through culturomics. Conclusions: Several of the identified bacteria, such as line-related sepsis-causing Delftia acidovorans and the pneumonia agent Acinetobacter pittii, can cause human diseases. Thus, both sequencing and culturomics methods are crucial for comprehensive understanding of the microbiota of D. nuttalli.

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“…Corynebacterium mucifaciens is known as normal flora of the skin and it can also be isolated from sterile body fluids, yet pathogenic strains of this bacteria have been identified in recent years and some cases of severe deadly infections caused by C mucifaciens have been reported. 1,2 This strain of Corynebacterium can be considered a human pathogen in immunocompromised patients; therefore, we find it necessary to investigate this bacteria in patients who have a defective immune system.…”

Section: Background and Importancementioning

confidence: 99%

An Unusual Case (Metastatic-Like Lesion) of Septic Cerebral Embolus Caused by Corynebacterium mucifaciens in a Diabetic Patient

Tahaei

Mencser

Reisz

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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Septic cerebral emboli can be a challenging diagnosis to give, especially if atypical bacterial infections are the cause of it. Correct diagnosis of this condition can change the management route of the patient and result in a nonsurgical treatment. To our best knowledge, this is the first case of septic cerebral embolus caused by Corynebacterium mucifaciens reported. In this study, a 65-year-old diabetic patient who have developed ketoacidosis and went into coma was investigated for a case of septic cerebral embolization. The patient developed a sudden right-sided hemiparesis, and the radiological findings showed a tumor-like lesion on the left hemisphere at the level of the internal capsule. At first glance, presence of a metastatic tumor could not be excluded; therefore, further laboratory tests and examinations were done to rule out metastatic lesions. The blood culture of the patient revealed a case of bacteremia caused by Corynebacterium mucifaciens and then a septic cerebral embolus was suspected, but due to the rarity of this pathogen causing such complications as well as the similarity of the lesion to a metastatic brain tumor, a biopsy was performed and the histopathological findings confirmed the diagnosis of a septic cerebral embolus. Corynebacterium mucifaciens should be considered a human pathogen in immunocompromised patients and it can cause cerebral septic embolization. Metastatic brain tumors and tuberculomas should be excluded; if the uncertainty of a metastatic tumor remains, biopsy can be performed and histological findings can amplify the diagnosis of septic cerebral embolus.

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Fatal case of bacteremia caused by an atypical strain of Corynebacterium mucifaciens

Cited by 7 publications

References 7 publications

Corynebacterium mucifaciensin an immunocompetent patient with cavitary pneumonia

Corynebacterium mucifaciensin an immunocompetent patient with cavitary pneumonia

Bacterial Microbiota in Unfed Ticks (Dermacentor nuttalli) From Xinjiang Detected Through 16S rDNA Amplicon Sequencing and Culturomics

An Unusual Case (Metastatic-Like Lesion) of Septic Cerebral Embolus Caused by Corynebacterium mucifaciens in a Diabetic Patient

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