Central nervous system involvement in Hodgkin's lymphoma associated with Epstein-Barr virus in a patient with AIDS: case report and review of the literature

Abstract

Intracranial and intraspinal involvement is a rare complication of Hodgkin's disease. We report a case of a patient with diagnosis of AIDS and Hodgkin's lymphoma who developed brain and spinal involvement at the time of the relapse of the neoplasm disease. Mixed cellularity histology was the subtype of Hodgkin's disease in our patient; we identified the Epstein-Barr virus genome in the Reed-Sternberg cells by immunohistochemistry and in situ hybridization.

Cerebellar involvement in Hodgkin’s lymphoma: an atypical site of relapse

“…Most CNS Hodgkin's lesions are supratentorial, with cerebral cortex and leptomeninges as the most frequently involved areas. The presence of cerebellar involvement and the existence of parenchymal metastases have also been described, as was seen in our patient [6,11]. Classic histological types are responsible for the majority of intracranial HL deposits.…”

“…In an extensive review of the English literature from 1952 to 1999, Nakayama et al described 25 reports communicating 48 cases [7]. In addition, 31 new cases have been described between 2000 and 2009 [2,4,5,[8][9][10][11][12][13][14]. Primitive HL of the CNS is even rarer.…”

“…Surgery, radiotherapy or chemotherapy has been advocated to be effective in the treatment of CNS involvement in HL [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Intracerebral Progression of Hodgkin Lymphoma in a Man with HIV

“…[4][5][6] We present the case of an HIV-seropositive patient with intracerebral progression of Hodgkin lymphoma after administration of systemic chemotherapy. [8][9][10][11] This case report highlights the frequent diagnostic dilemmas and diffi culties encountered in the management of patients presenting with symptoms emanating from CNS pathology and underlines the need for less invasive and more sophisticated diagnostic tests for intracerebral Hodgkin lymphoma. 7 This includes recurrent and/or newly diagnosed cases in either immunocompromised or immunocompetent patients.…”

“…[8][9][10][11] The fi rst report was described in 1991, and in all cases, intracranial involvement occurred after chemotherapyinduced disease remission. [8][9][10][11] The fi rst report was described in 1991, and in all cases, intracranial involvement occurred after chemotherapyinduced disease remission.…”