Prevalence of maternal group B streptococcal colonization and related risk factors in a Brazilian population

Zusman, Alexander S.; Baltimore, Robert S.; Fonseca, Sílvia Nunes Szente

doi:10.1590/s1413-86702006000400005

Cited by 30 publications

(34 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The detected prevalence of 17.3% is similar to a global prevalence rate of 17.9% determined in a recent meta-analysis [20], lower than rates found in Brazil (17.9%–25.6%) [8–10], but relatively high compared with rates reported in Peru (6%) [7], Argentina (7.6%) [21], and Mexico (4%–10%) [22, 23]. Previous smaller descriptive studies in Guatemala found GBS colonization rates as low as 2.5% among predominately native Mayan, rural populations [24] to 14.4% among predominately urban, nonindigenous populations [25].…”

Section: Discussionsupporting

confidence: 82%

Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome

Rick

Aguilar

Cortes

et al. 2017

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Background.Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries.Methods.A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks’ gestation. Vaginal and rectal swabs were processed using Lim broth and GBS CHROMagar then agglutination testing. Risk factors were assessed using multivariate analysis. Vaginal microbiota were profiled by 16S ribosomal ribonucleic acid sequencing in a subset of 94 women.Results.Of 896 pregnant women, 155 (17.3%; 95% confidence interval [CI], 14.9–19.9) were GBS colonized. Colonization was associated with history of previous infant with poor outcome (odds ratio [OR], 1.94; 95% CI, 1.15–3.27) and increasing maternal age (OR, 1.05; 95% CI, 1.02–1.09). Multiparity was protective (OR, .39; 95% CI, .21–.72). Four (6%) GBS-exposed infants had early-onset neonatal sepsis. Vaginal microbiome composition was associated with previous antibiotic exposure (P = .003) and previous low birth weight infant (P = .03), but not GBS colonization (P = .72). Several individual taxa differed in abundance between colonized and noncolonized women.Conclusions.Group B Streptococcus is prevalent in pregnant women from Guatemala with different risk factors than previously described. Although the vaginal microbiome was not altered significantly in GBS-colonized women, use of antibiotics had an effect on its composition.

show abstract

Section: Discussionsupporting

confidence: 82%

Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome

Rick

Aguilar

Cortes

et al. 2017

Open Forum Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…This percentage was similar to that reported previously [1]. In other studies conducted in our region, a wide range of between 3% and 21% has been reported [4]. Fifteen (16.7%) of the 90 pregnant women with one or more clinical risk factors for early‐onset GBS defined by the CDC were colonized by GBS; for the preterm birth group the prevalence was 23.9% (Table 2).…”

Section: Comparison Of Characteristics Between the Hospital Populatiosupporting

confidence: 88%

Group B streptococcus colonization among pregnant women in Uruguay

Laufer

Scasso

Sosa

et al. 2008

Intl J Gynecology & Obste

View full text Add to dashboard Cite

SynopsisThe prevalence of group B streptococcus colonization in pregnant women was 17.3% in the largest maternity hospital in Uruguay. KeywordsColonization; Group B streptococcus; Pregnant women; Uruguay Group B streptococcus (GBS) is one of the most common causes of neonatal sepsis. In the United States, 5%-10% of neonatal deaths are caused by this organism [1]. Early-onset GBS disease is defined as an infection occurring in the first week of life and accounts for approximately 70% of all GBS diseases in the first 3 months of life [2]. Sepsis develops in approximately 1% of neonates born to colonized women. It has been estimated that between 10%-30% of pregnant women are colonized by GBS. These figures have been reported mainly from high-income countries, with few studies from Latin America [1]. The objective of the present study was to determine the prevalence of GBS colonization in pregnant women using the method recommended by the Centers for Disease Control and Prevention (CDC) [2].Pregnant women admitted to the Pereira Rossell Hospital, the largest public maternity unit in Uruguay, were asked to participate in the study. Inclusion criteria were pregnant women in labor or admitted for elective cesarean delivery; gestational age between 32 and 41 weeks; and signed consent forms. If a woman had been tested for GBS during prenatal care and the culture was positive, she received treatment after the study sample had been obtained. Exclusion criteria were pregnant women who had received antibiotics within 1 week before being admitted to hospital and women who declined to participate.During a 2-month period in 2008, a total of 300 pregnant women were selected at random from a total of 846 women eligible women admitted to the hospital. The random allocation scheme was derived from a computer-generated list of numbers using sealed envelopes that were opened at the moment of enrollment. Treating physicians were instructed to collect a specimen with one swab that collected specimens from the vagina and rectum. The swab was placed into a recommended container with adequate transport medium. As recommended by the CDC [2], the specimens were incubated in Todd-Hewitt broth supplemented with nalidixic acid and gentamicin. After 18-24 hours of incubation at 35 ± 2 °C in ambient air, specimens were subcultured onto a sheep blood agar plate, and a Granada medium plate was made and incubated at the recommended incubation conditions [3]. Observation of cultures was conducted at 24 hours and all negative culture plates were reincubated for an additional 18-24 hours and then re-examined. All GBS isolates were tested for drug susceptibility as recommended by the CDC [2], including clindamycin and erythromycin.The characteristics of the participants are shown in Table 1. The study population was similar to the population of pregnant women who had received care in the hospital during the previous year. A total of 52 pregnant women from the sample of 300 were found to be colonized with GBS (17.3%; 95% CI, 13.2-21.1). This percentage ...

show abstract

“…The carriage rate found by us was higher when compared with the results described in Santa Catarina (21.6%) (Pogere et al , 2005), Ribeirão Preto (17.9%) (Zusman et al , 2006) and São Luis (20.4%) (Costa et al , 2008) (Fisher’s Exact Test, p = 0.0192, p = 0.005, p = 0.0143, respectively). However, the present data were similar to those described by other authors in Brazil: Rio de Janeiro (26%) (Benchetrit et al , 1982) and Campinas (27.6%) (Nomura et al , 2006).…”

contrasting

confidence: 56%

Prevalence of Group B Streptococcus serotypes III and V in pregnant women of Rio de Janeiro, Brazil

Soares

Alviano

Santos

et al. 2013

Braz. J. Microbiol.

View full text Add to dashboard Cite

show abstract

Prevalence of maternal group B streptococcal colonization and related risk factors in a Brazilian population

Cited by 30 publications

References 20 publications

Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome

Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome

Group B streptococcus colonization among pregnant women in Uruguay

Prevalence of Group B Streptococcus serotypes III and V in pregnant women of Rio de Janeiro, Brazil

Contact Info

Product

Resources

About