Profound peripheral T-lymphocyte depletion and activation in disseminated tuberculosis

Rodrigues, Denise; Salomão, Reinaldo; Kallas, Esper G.

doi:10.1590/s1413-86702006000100012

Cited by 3 publications

(2 citation statements)

References 11 publications

(20 reference statements)

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“…Cellular immune responses especially those produced by T lymphocytes play an important role in controlling the replication of Mycobacterium tuberculosis (MTB) as well as neutrophils play a role in naive immunity to MTB. Lymphopenia, neutrophilia and monocytosis are the most common hematological abnormalities in TB (8,9) . The neutrophil-lymphocyte ratio (NLR) is an inflammatory marker that can be used to estimate various clinical conditions including cancer and coronary heart disease and also shows differences based on the type of infection.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis

2021

IJFMT

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Background: Tuberculosis (TB) is one of the top 10 causes of death in the world and the most common cause of death with single infectious agent. The neutrophil-lymphocyte ratio is a cheap and fast marker of inflammation that has been widely studied in TB. The aimed of this study was to investigate Neutrophillymphocyte ratio (NLR) in TB with positive Acid-Fast Bacilli (AFB) and negative AFB. Methods: This was a retrospective study that included TB patients data from the medical records in two hospitals in Palu, Indonesia. A total of 150 TB patients were involved in this study consisting with positive and negative AFB TB suspect. Neutrophil, lymphocyte and NLR data were compared with the Mann-Whitney test. Results:The study shows a significant difference of neutrophils and lymphocytes percentage between positive AFB TB patients (80 subjects, 53.3%) and negative AFB TB patients (70 subjects, 46.7%) with (p < 0.001) as well as NLR (p < 0.001). The percentage of Neutrophils was significantly higher in positive AFB TB compared to negative AFB tuberculosis (81.18 ± 8.52 vs. 55.02 ± 9.80), lymphocyte percentage were found to be significantly lower in positive AFB TB compared with negative AFB TB (12.72 ± 7.51 vs 28.69 ± 12.01). Additionally, NLR were significantly higher in positive AFB TB compared with negative AFB TB (10.20 ± 9.53 vs 2.47 ± 1.56). Conclusion: There is a significant increase in the number of neutrophils, a decrease in lymphocytes and an increase in NLR among positive AFB TB compared with negative AFB TB.

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