Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report

Monteiro, Eduardo José Bellotto; Caron, Daiane; Balda, Carlos Alberto; Franco, Marcello; Pereira, Aparecido B.; Kirsztajn, Gianna Mastroianni

doi:10.1590/s1413-86702006000100011

Cited by 10 publications

(7 citation statements)

References 28 publications

(35 reference statements)

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“…The rarity of clinical cases of ANCA-associated vasculitis in HIV patients suggests that HIV may in fact lessen the chance of developing active vasculitis [26]. Similarly, there has been only 1 case report on anti-GBM disease in a patient with HIV [27]. The reasons why these vasculitides are rare in patients with HIV are unknown.…”

Section: Hiv-infected Patients With Kidney Disease Other Than Hivanmentioning

confidence: 99%

Treatment of HIV-Associated Nephropathies

Elewa

Sandri

Rizza³

et al. 2011

Nephron Clin Pract

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In patients with HIV, the use of highly active antiretroviral therapy has improved life expectancy. At the same time, this increase in life expectancy has been associated with a higher frequency of chronic kidney disease due to factors other than HIV infection. Besides HIV-associated nephropathy, a number of different types of immune complex and non-immune complex-mediated processes have been identified on kidney biopsies, including vascular disease (nephrosclerosis), diabetes, and drug-related renal injury. In this setting, renal biopsy needs to be considered in order to obtain the correct diagnosis in individual patients with HIV and kidney impairment. Many issues regarding the optimal treatment of the different pathological processes affecting the kidneys of these patients have remained unresolved. Further research is needed in order to optimize treatment and renal outcomes in patients with HIV and kidney disease.

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Section: Hiv-infected Patients With Kidney Disease Other Than Hivanmentioning

confidence: 99%

Treatment of HIV-Associated Nephropathies

Elewa

Sandri

Rizza³

et al. 2011

Nephron Clin Pract

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“…We propose that stochastic Cellular Automata simulation is the most appropriate technique to investigate the therapeutic outcome of drug prescriptions in combination with interrupted treatment by plasma apheresis, which has been suggested in some reports to be a promising treatment option for patients in the later stages of HIV infection [20]- [26].…”

Section: Discussionmentioning

confidence: 99%

Investigating Combined Drug and Plasma Apheresis Therapy of HIV Infection by Double Compartment Cellular Automata Simulation

Moonchai¹,

Lenbury²

2016

IJCTE

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Abstract-It has become widely acknowledged that potent combination drug therapy of patients infected with Human Immunodeficiency Virus can significantly prolong life, but exerts detrimental effect on a patient's quality of life. Lymph nodes and lymphatic tissue are busy sites of immunological activity. Germs are brought there by the cells of the immune system to be broken down and analyzed. However, clinics commonly used blood tests for viral load therein to assess the effect of drug therapy. We are therefore of the opinion that most cellular automata models in the past that only considered viral proliferation in the lymph node cannot give a sufficiently accurate picture of the dynamics of HIV infection, especially when the impact of treatments that combine both drugs and plasma apheresis are in question. We thus present a two-compartment cellular automata (CA) model, which simulates the dynamics of HIV infection in both the lymph node and blood compartments when drugs and plasma apheresis are applied simultaneously. It is found that the combined usage of these two types of therapy yields more favorable outcome than the sole use of plasma apheresis.

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“…To our knowledge, only three cases of HIV infection and concomitant anti-GBM disease have been reported. [3][4][5] Each case had a different presentation, course of treatment, and clinical outcome ( Table 2). Antibody formation to the GBM has been linked to a conformational change in quaternary structure of the a-345 noncollagenous-1 (NC1) hexamer.…”

Section: Discussionmentioning

confidence: 99%

AKI in an HIV Patient

Hartle

Carlo

Dwyer

et al. 2013

Journal of the American Society of Nephrology

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The renal manifestations of patients infected with HIV are diverse. Patients may have podocytopathies ranging from a minimal-change-type lesions to FSGS or collapsing glomerulopathy. Furthermore, such patients produce a variety of autoantibodies without clinical signs of the disease. Antiretroviral drugs also cause renal injury, including crystals and tubular injury, acute interstitial nephritis, or mitochondrial toxicity. In these circumstances, it is essential to perform a renal biopsy for diagnosis and to guide treatment. Here we describe a patient with HIV who presented with AKI and hematuria without concomitant systemic manifestations. Renal biopsy elucidated the cause of acute deterioration of kidney function.

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Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report

Cited by 10 publications

References 28 publications

Treatment of HIV-Associated Nephropathies

Treatment of HIV-Associated Nephropathies

Investigating Combined Drug and Plasma Apheresis Therapy of HIV Infection by Double Compartment Cellular Automata Simulation

AKI in an HIV Patient

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